The Pfam:SIR2 domain within your query sequence starts at position 14 and ends at position 198, and its E-value is 3.8e-61.

GAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQP
Pfam:SIR2

Pfam:SIR2
Pfam domain

Pfam ACC: