The Pfam:SIR2 domain within your query sequence starts at position 58 and ends at position 256, and its E-value is 5.3e-50.

GAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYP
Pfam:SIR2

Pfam:SIR2
Pfam domain

Pfam ACC: