The Pfam:RhoGEF domain within your query sequence starts at position 304 and ends at position 405, and its E-value is 1.2e-25.

ICEQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQRMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKNVEAALHAMKNVAQLINE
Pfam:RhoGEF

Pfam:RhoGEF
Pfam domain

Pfam ACC: