The Pfam:SIR2 domain within your query sequence starts at position 41 and ends at position 181, and its E-value is 4.8e-20.

KFDTTFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKTRGLRACRGELRDTILDWEDSLPDRDLMLADEASRTADLSVTLGTSLQIRP
Pfam:SIR2

Pfam:SIR2
Pfam domain

Pfam ACC: