Taxonomic distribution of proteins containing SOCS_box domains

The SOCS_box domain within your query sequence starts at position 381 and ends at position 420, and its E-value is 7.48e-10.

The SOCS box: a tale of destruction and degradation.

Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ
Trends Biochem Sci. 2002; 27: 235-41

Although initially identified in the suppressor of cytokine signaling(SOCS) family of proteins, the C-terminal SOCS box has now been identifiedin more than 40 proteins in nine different families. Growing evidencesuggests that the SOCS box, similar to the F-box, acts as a bridge betweenspecific substrate-binding domains and the more generic proteins thatcomprise a large family of E3 ubiquitin protein ligases. In this way, SOCSproteins regulate protein turnover by targeting proteins forpolyubiquitination and, therefore, for proteasome-mediated degradation.