The Pfam:SIR2 domain within your query sequence starts at position 134 and ends at position 276, and its E-value is 1.1e-22.

RPVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLK
Pfam:SIR2

Pfam:SIR2
Pfam domain

Pfam ACC: