Taxonomic distribution of proteins containing UBA domains

The UBA domain within your query sequence starts at position 111 and ends at position 148, and its E-value is 3.1e-11.

Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr.

Dieckmann T, Withers-Ward ES, Jarosinski MA, Liu CF, Chen IS, Feigon J
Nat Struct Biol. 1998; 5: 1042-7

The HIV-1 protein Vpr is critical for a number of viral functions including a unique ability to arrest T-cells at a G2/M checkpoint and induce subsequent apoptosis. It has been shown to interact specifically with the second UBA (ubiquitin associated) domain found in the DNA repair protein HHR23A, a highly evolutionarily conserved protein. This domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. The three dimensional structure of the UBA domain, determined by NMR spectroscopy, is presented. The protein domain forms a compact three-helix bundle. One side of the protein has a hydrophobic surface that is the most likely Vpr target site.

The R3H motif: a domain that binds single-stranded nucleic acids.

Grishin NV
Trends Biochem Sci. 1998; 23: 329-30

SMART, a simple modular architecture research tool: identification of signaling domains.

Schultz J, Milpetz F, Bork P, Ponting CP
Proc Natl Acad Sci U S A. 1998; 95: 5857-64

Accurate multiple alignments of 86 domains that occur in signaling proteins have been constructed and used to provide a Web-based tool (SMART: simple modular architecture research tool) that allows rapid identification and annotation of signaling domain sequences. The majority of signaling proteins are multidomain in character with a considerable variety of domain combinations known. Comparison with established databases showed that 25% of our domain set could not be deduced from SwissProt and 41% could not be annotated by Pfam. SMART is able to determine the modular architectures of single sequences or genomes; application to the entire yeast genome revealed that at least 6.7% of its genes contain one or more signaling domains, approximately 350 greater than previously annotated. The process of constructing SMART predicted (i) novel domain homologues in unexpected locations such as band 4.1-homologous domains in focal adhesion kinases; (ii) previously unknown domain families, including a citron-homology domain; (iii) putative functions of domain families after identification of additional family members, for example, a ubiquitin-binding role for ubiquitin-associated domains (UBA); (iv) cellular roles for proteins, such predicted DEATH domains in netrin receptors further implicating these molecules in axonal guidance; (v) signaling domains in known disease genes such as SPRY domains in both marenostrin/pyrin and Midline 1; (vi) domains in unexpected phylogenetic contexts such as diacylglycerol kinase homologues in yeast and bacteria; and (vii) likely protein misclassifications exemplified by a predicted pleckstrin homology domain in a Candida albicans protein, previously described as an integrin.

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway.

Hofmann K, Bucher P
Trends Biochem Sci. 1996; 21: 172-3