 FATC | |
|---|---|
| SMART ACC: | SM001343 |
| Description: | The FATC domain is named after FRAP, ATM, TRRAP C-terminal (PMID:10782091). The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability (PMID:15772072). |
| InterPro ACC: | IPR003152 |
| InterPro abstract: | This entry represents the FATC domain in Serine/threonine-protein kinases and related proteins, including pseudo-kinases such as members of the SAGA and NuA4 complexes. The TOR1 FATC domain, in its oxidised form, consists of an α-helix and a well-structured COOH-terminal disulphide-bonded loop. Reduction of the disulphide bond dramatically increases the flexibility within the COOH-terminal loop … expand |
| GO function: | protein binding (GO:0005515) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 7 901 FATC domains in 7 895 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing FATC domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing FATC domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the FATC domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a FATC domain which could be assigned to a KEGG orthologous group, and not all proteins containing FATC domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.