Consensus terms for the A2M domain 

6238.CBG17408_from_503_to_595TWL-------------------FDAIVLER------------------NGTKNV---VAT
CONSENSUS/80%    shh......................h.hs...................puthph...th.
CONSENSUS/65%    ohh...................hs.lphst..................pGpsph...shp
CONSENSUS/50%    oal...................asslslss..................sGpssl...shs


6238.CBG17408_from_503_to_595TPDN-VGQ--WALNSAFWWH--------------GRVSLFPGETKYIQTTK---PIFLEV
CONSENSUS/80%    lPct.hsp..h.h.uhshs.t.............ths.ht.....phhshp...shhlp.
CONSENSUS/65%    lPDs.lTs..Wplhuhuhsss.............uhG.spt....plpshp...shhlph
CONSENSUS/50%    lPDo.lTo..WclpAlulosst............GlGhsss....clpVtc...PFalsl


6238.CBG17408_from_503_to_595DMPKNV----------------YVNETISPLLTVTGIDLA---KSRET---FVIC
CONSENSUS/80%    thPh.l................h.s-th.h.h.lhNh.t....tthph...plth
CONSENSUS/65%    sLPh.l................hpG-phpltsslhNhhs....pshps...plpl
CONSENSUS/50%    sLPhol................t+GEplplplsVaNats....pshcl...pVsL

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T