Consensus terms for the BIR domain

2497242/1-0      QEEEARLASFR--NWPFY---VQGI-SPCVLSEAGFVFTGK---------------QDTV
CONSENSUS/80%    ...ttRhtoFt..taP............pthApuGhhhhs.................Dps
CONSENSUS/65%    sp.psRlpTFp..sWP.....htth.tspplApAGFaasuh...............sDpl
CONSENSUS/50%    sscssRLpTFp..sWP.....ssps.sscpLAcAGFaYsGt...............uDpV


2497242/1-0      QCFSCGGCLGNWEEGDDPWKEHAKWFP----KCEFLRS
CONSENSUS/80%    tChhCthtlttW..t-pshtpHtph.s....pC.al..
CONSENSUS/65%    pCahCshplpsWp.sDcPhpcHt+a.P....pC.Flpt
CONSENSUS/50%    +CFaCsspLcsWcpsDDPap-Hp+asP....sCsFlps

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T