Consensus terms for the CARD domain

HS13021_1        MHPHHQETLKKNRVVLAKQLLLS---ELLEHLLEKDIITLEMRELIQAKVGSFSQ--NVE
CONSENSUS/80%    hpt.t.phhcpthhthhp.h.hp....lLp.Lhtptlhs.p..-hhpthsst.cc..hh.
CONSENSUS/65%    Mpt.ppphlc+pphplhpplths...tlL-hLhtcslls.pph-hlpthsst.cc..sht
CONSENSUS/50%    Msspcpcsl++s+lcLscpLtl-...plL-sLlp+slLspccpEtIpptssspcc..sRp


HS13021_1        LLNLLPKRGPQAFDAFCEALRE--TKQGHLEDMLLT
CONSENSUS/80%    hl..l.p+ts.th.hhhp.hpp....pthl.phh..
CONSENSUS/65%    hlptl.p+ustshthhhpshpp....pphLsphh..
CONSENSUS/50%    Llcslpc+GspAhssalcsLpc...scspLschLts

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T