Consensus terms for the CASc domain

LAP3_HUMAN       QYNMNFEKL--GKCIIINNKNFDKVTG-----------MGVRNGTDKDAEALFKCFRSLG
CONSENSUS/80%    .Y.hppp....thsLIlssppFp...............h..R.GsphDhtthpphhptLs
CONSENSUS/65%    hYphppppt..GlsLIIsNppFpt..............lt.RpGsphDtptLpchhpsLG
CONSENSUS/50%    tYchpc+sp..GlALIIsNccFcp..............LssRsGoclDtcsLpclFpsLG


LAP3_HUMAN       FDVIVYNDCSCAKMQDLLKKASE-EDHTNAACFACILLSHG-------EENVIYGKD---
CONSENSUS/80%    apV.hhpshpttph...lpphut..pHtstDshhhslhSHG.........thlhuhs...
CONSENSUS/65%    YpVpshpslotp-h.phlpphAp..-HpssDShhhsllSHG.......tttulhGsc...
CONSENSUS/50%    YsVcl+scLTuc-Mpppl+cFAs.s-HpcuDShllVlLSHG.......ppsuIaGsDp..


LAP3_HUMAN       -----------GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGI--------
CONSENSUS/80%    ...........s.h.hpplhphFps.pC.pLhsKPKlhhlQACpG.t.pt.h........
CONSENSUS/65%    ...........shlplcplhphFssspCsoLtsKPKlhhIQACcG.phsssl........
CONSENSUS/50%    ...........sslplccIashFsuspCPSLtsKPKlFhIQACRGpcpcsulhlpsssss


LAP3_HUMAN       -------------------------QADSGPINDTDANPRY--KIPVEADFLFAYSTVPG
CONSENSUS/80%    ............        ................ttshh..ph.hctDhlhhhuosst
CONSENSUS/65%    ............        ...............ptsuhp..ph.scuDFlhthSosss
CONSENSUS/50%    ............        .........t...thcssulp..+lPsEADFlhuaSTsPG


LAP3_HUMAN       YYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVNDRVA---RHFES-QSDDPHFH
CONSENSUS/80%    .hSaRp.tpGShalppLhphhpp.hupphclhplhhtVpt.ht.................
CONSENSUS/65%    hhSaRssppGShaIpsLhphhpp.hupphclh-lhhcVpppht...pt.t..........
CONSENSUS/50%    alSWRcsscGSWFIQuLspplcc.aucsp-Lh-ILscVsppVp...scpst........t


LAP3_HUMAN       EKKQIPCVVSM-LTKELYFSQ
CONSENSUS/80%    .tpphPs..ph.Lp+.hhh..
CONSENSUS/65%    .cpQhPshhph.Ls+phahhs
CONSENSUS/50%    t+cQhPshssssLTKcLYhaP

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T