Consensus terms for the EGF domain

NTC3_MOUSE/33-   SCRE---------------LQCPVGI-----PCQQTA--------------RGPRCA---
CONSENSUS/80%    .Ct..................C..........C..................tth.C....
CONSENSUS/65%    pCtt................sCpp.......pChst...............ssapC....
CONSENSUS/50%    -Csst..............ssCpss......pChss...............uuapC....


NTC3_MOUSE/33-   ----CP-----PGLSG--------------PSCR
CONSENSUS/80%    ....C.......Ga.h................C.
CONSENSUS/65%    ....C.......Gats..............ppCp
CONSENSUS/50%    ...pCs.....sGapu..............psCp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T