Consensus terms for the FYVE domain

FAB1_YEAST/1-6   LSKEYWMKDESSKEC--FSC-GKTFNT-----------FRRKHHCRICGQIFCS----SC
CONSENSUS/80%    ..t..W..s...t.C....C.tt.Fsh...........hpR+HHCRtCGtlhCt....tC
CONSENSUS/65%    tptspWhs-...ppC...tC.pppFsh...........hpR+HHCRpCGplhCp....pC
CONSENSUS/50%    pssscWhcDp.sspC..hsC.cssFsh...........hsR+HHCRsCGclaCs....sC


FAB1_YEAST/1-6   TLLIDGDRFGCHA-------------------KMRVCYNCYEHADT
CONSENSUS/80%    stt.h.h...t......................h+lCp.Chp.h.t
CONSENSUS/65%    sppph.hs..t......................hRVCcsCapphpt
CONSENSUS/50%    Sscpsslsptspt...................slRVCcsCasplsp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T