Consensus terms for the HEPN domain 

18160453/9-120   LRQAERDLIKAENDL-KTGDWDSAAFWSQQCAEKALKALL-LNAGKAYRG-HELLELA--
CONSENSUS/80%    hppA.p.hp.Ap..h.ptshat.usahspQuhphhlKshl.h.htt...t.HslhtLh..
CONSENSUS/65%    hcpAhchhctAchsh.ppGhYshusFhupQusEhslKuhL.hthssth.tsHslppLh..
CONSENSUS/50%    lccAccaLcsA+psl.csGtYshAsFtupQAlEhuLKulL.lplsuphPcoHslpcLL..


18160453/9-120   ----RVIKEEIGV------DVSPIEEDLRELTIHYVISRYPNA---ANAVPYELYDEKKA
CONSENSUS/80%    ......htp.ht.........pp.ht.h..lp..hh.sRY..............htcp.u
CONSENSUS/65%    ....p.ltphht.........cp.hphhphLpptYlhoRY...........h..asccpA
CONSENSUS/50%    ....ptlpchtph.....c.hcchtcplphLcctYltSRYsph.......shphYs+ccA


18160453/9-120   RELVERARRV
CONSENSUS/80%    cphlphsctl
CONSENSUS/65%    -chlchscpl
CONSENSUS/50%    EcslchuEcl

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T