Consensus terms for the IL1 domain 

IL1B_HUMAN       VRSLNCTLRDS-QQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALG
CONSENSUS/80%    l.p.phhlpDt.pQp.lh..ss..LhAhhL...shpptVhFsMshhpup.pssplPVhLt
CONSENSUS/65%    lhphchpLpDs.pQpslh.sss..LpAhaLp..slpppVhFsMuhhpuctpssKlPVsLt
CONSENSUS/50%    VpspcCpLpDs.NQKoLVLuusppL+AlHLputNLccpVlFDMSFVpuEccDsKIPVsLG


IL1B_HUMAN       LKEKNLYLSCVLKDDKPTLQLESVDPKNYPK-KKMEKRFVFNKIEINNKLEFESAQFPNW
CONSENSUS/80%    lptppLalSs..c.DpPsL.hE.s-..ph.c.pchphhFha.+h..tsps.FcSs.aPph
CONSENSUS/65%    IppppLalSs.tc.DpPsLphE.s-spph.K.cch-phFsapKp..tsps.FcSstaPsh
CONSENSUS/50%    I+csNLYLSCVpKsDcPTLQLEpVDPscYPK.+-MEKRFVFpKpEhss+lEFESAuaPNW


IL1B_HUMAN       YISTSQAENMPVFLGGTKGG-QDITDFTMQ
CONSENSUS/80%    aIuTpptp...Vhhups.s....lTDF.h.
CONSENSUS/65%    aIuTpQtcp..VaLups.st.p.ITDFphp
CONSENSUS/50%    YISTSQsEphPVFLGsspuu.pDITDFpMp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T