Consensus terms for the IL6 domain 

IL6_HORSE/1-15   IKYILGKISALKNEMCNNFSKCENSKEVLAENNLNLPKMAEKDGCFQSGFNQETCLMKIT
CONSENSUS/80%    lphlh.tlsthpcchCtt.p.C.tpc..lsp.pLpLPph..hDtChppGaptp.CLhplt
CONSENSUS/65%    lpalltclsthp+-lCpppphCpspc.sLucssLpLPphtcpDuCappGaNpcsCLh+lp
CONSENSUS/50%    I++ILs-IuALRKELCsssspCcsS+EsLAENNL+LPKMsEKDGCFQoGFNp-sCLlKIo


IL6_HORSE/1-15   TGLSEFQIYLEYLQNEFKG--EKENIKTMQISTKVLVQILMQKMKNPE-VTTPDPTAKSS
CONSENSUS/80%    sGLhtap.hLphlts.h.t..pt.phchhQ.sspsLhp.l.pphps.t..hhs.Pt.pts
CONSENSUS/65%    sGLhEapshLcalpsphtp..ppppscslQhsscsLhp.lppchcsLt..shssPtssts
CONSENSUS/50%    oGLLEFQlYL-YLpNcFcc..sc-sl-sLQlSTKsLIpILpQclKDLstlssPsPssNsu


IL6_HORSE/1-15   LLAKLHSQNEWLKNTTTHLILRSLEDFLQFSLRAVR
CONSENSUS/80%    hhsphpu..p..pphsh.hlLpshccFLp.shRulR
CONSENSUS/65%    hhs+hputppW.+phsshhILpshccFLphslRulR
CONSENSUS/50%    LLsKLpSQN-Wl+ssTsaLILuSLE-FLQhoLRALR

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T