Consensus terms for the IRS domain

7955.ENSDARP00000068140_from_147_to_246EVNEF--LVTVQRTEA------------SERCGLS--GNYW-------------------
CONSENSUS/80%    ..t.a...V.h..t..............ttp..h...s......................
CONSENSUS/65%    .tp.F...Vhlttsts............spphthp..G.hh...................
CONSENSUS/50%    psppF..pVslppsss............up+psls..Gshh...................


7955.ENSDARP00000068140_from_147_to_246------LRANMDNLIL-----------------KDPKTKKDLLIWPYKLLRRY-------
CONSENSUS/80%    ......ltlstptl.l......................t...h.a.h..lR+a.......
CONSENSUS/65%    ......LplsppplhL.....................stp.hhpWPlptlRRa.......
CONSENSUS/50%    ......LploscslsL.................tttpscpslhpWPLpsLRRY.......


7955.ENSDARP00000068140_from_147_to_246-GRD--RVMFSFEAG--RRCESGPG-NFTFE--TKQGNEIFHIVE-ESIREQKA
CONSENSUS/80%    .Ghs..tshF.hEsG..pps..G.G.hahh...s..spplhphl..thh.t..t
CONSENSUS/65%    .Gts..pshFshEuG..RpCssGpG.hahhp..stpupplaphlp.pthpshtp
CONSENSUS/50%    .Gps..cshFoFEuG..R+CsoGpG.lasFp..ospuccIaptlp.sshputpp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T