Consensus terms for the MBD domain

O42403/1-78      GPMYDDPTLPEGWTRKLKQRKSG--RSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTS
CONSENSUS/80%    ts.hphP.L..GWcR.hh.+p.....tthph-shYhsPsGtph+ohsplhpYlttstsh.
CONSENSUS/65%    ts.hchP.L..GW+R.hh.Rpss...tts+h-lhYhoPsGcph+ohs-ltcYLttssshp
CONSENSUS/50%    ssplcsP.LspGWRRpsshR+sG..psuu+tDVaYhSPsGK+LRS+sEls+YLscsu-po


O42403/1-78      LDPND-------FDFTVTGRGSPSRRE
CONSENSUS/80%    h...........FsFssth.h..h.p.
CONSENSUS/65%    hh..........FsFssth.hs.hhp.
CONSENSUS/50%    lthp........FDFssplssusphps

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T