Consensus terms for the MBT domain

AAC69438/1-104   WSWESYL-----EEQKAITAPVSLFQ-----DSQAVTHNKNGFKL-------GMKLEGID
CONSENSUS/80%    hpWttal.....p.tts.shs.thF...............p.Fp........sh+LEshs
CONSENSUS/65%    hsWppaL.....ppssupssP.phF........t.s....ptFph.......GM+LEslD
CONSENSUS/50%    asWccYL.....ccsuupsAPsclF........pssssspssF+l.......GMKLEAlD


AAC69438/1-104   P-----------QHPSMYFILTVAEVCGY-RLRLHFD------------GYSEC------
CONSENSUS/80%    .............pst.hhhAol.plhst.hhhlph-............t.pp.......
CONSENSUS/65%    h...........pssphhplAoVhplhut.hlhlpa-............uhcst......
CONSENSUS/50%    h...........psPsplsVATVscVpGp.RLpl+aD............Gh-cp......


AAC69438/1-104   HDFWVNANSPDIHPAGWFEKTGHKLQLP
CONSENSUS/80%    .phhhphpS..laPhGast.psh.lpsP
CONSENSUS/65%    h-aWhchpSstIaPlGWsptsuh.LpsP
CONSENSUS/50%    aDFWlcscSs-IaPlGWCppsGasLpPP

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T