Consensus terms for the MutL_C domain

290318.Cvib_1624_from_420_to_5VAEVKIWQLHNKYLICQ----IKTG-------------------LMIIDQHVAHERVLYE
CONSENSUS/80%    ....hhsphtttallht...........................lhllD.+succ+lhhc
CONSENSUS/65%    ....hluQlptpallsp...........................LhllDQHAAcERlhaE
CONSENSUS/50%    s.htsluQlcssYIlsp....stps...................LhllDQHAAHERltaE


290318.Cvib_1624_from_420_to_5R------AVDVMETSVPN------------------SQQLLFPQKVELRPWDWEIFEEIR
CONSENSUS/80%    .......h.t...........................p.lh.s..hths..p..hh.p..
CONSENSUS/65%    t......hhpthtt......................tQ.LLhPhhlplstt-hthltp..
CONSENSUS/50%    p......lppthspt.....................sQsLLhPlslcLoss-tthlpct.


290318.Cvib_1624_from_420_to_5----DDLYRLGFNLSLFGSRT--------------VMIEGVPQD---VRPGSEVSILQDM
CONSENSUS/80%    ....t.htphGh.hp..t.................hhlpthP.....htt.........h
CONSENSUS/65%    ....p.LpphGhplp.hu.t...............hhlpthPsh...htptpht...t.l
CONSENSUS/50%    ....-pLpclGlcl-shGsp...............ltl+ulPsh...Lspssspthhppl


290318.Cvib_1624_from_420_to_5IAEYSENA---------------------------------------SKLKLEKRDNLAK
CONSENSUS/80%    hp.h.p...............................................hhtthht
CONSENSUS/65%    hphhtp.t..........................................h.phhpplhs
CONSENSUS/50%    l-hlpctt.......................................t..htpthccllu


290318.Cvib_1624_from_420_to_5SYSCRNAIMTGQKL
CONSENSUS/80%    .hus+tulhhsp.h
CONSENSUS/65%    phAC+sul+ssphL
CONSENSUS/50%    ohAC+uul+uscpL

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T