Consensus terms for the PI3Ka domain

PI3K_ARATH       -DRDLKP--SNIERKSIQRVLKYPPTRTLSGDERQLLWKFR-FSLMSEKRALT-------
CONSENSUS/80%    ...pht...t.p.tp.h.tlht..s...lptpcpthlWphR.hhh.p..psls.......
CONSENSUS/65%    ..hchps..stp.pctlpplhphssshtLspc-+pllWchR.hhh.p.scuLs.......
CONSENSUS/50%    .tp-l+s..sscp+cpLcsIlpp-PspsLosEE+cLlW+aR.ahlpspPcALs.......


PI3K_ARATH       ---KFLR--CVEWSDVQEAKQAIQLMYKW-----EMIDVCDALELLSPLFES--------
CONSENSUS/80%    ...phL...sh.Wp..p.htphh.hh.pW.....s.hp..puLpLLsstass........
CONSENSUS/65%    ...KhLt..slpWsptptlspshtlltpW.....s.lsstpALELLsspasc........
CONSENSUS/50%    ...KlLp..uVsWscsspVscshsLLcpW.....sslcst-ALELLsssFsD........


PI3K_ARATH       --------------------------EEVRAYAVSVLER-ADDEELQCYLLQLVQALRFE
CONSENSUS/80%    ............................lRthAVphLpt.hssppl..aL.QLVQsl+a-
CONSENSUS/65%    ...........................tVRpaAVppLcp.hss--LhhYLlQLVQALKYE
CONSENSUS/50%    ..........................spVRpaAVppLcp.hoD-ELltYLLQLVQALKYE


PI3K_ARATH       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


PI3K_ARATH       --RSDRSCLSQFLVQRALQNI-ELASFLRWYVAVEL------HDHVY----AKRFYSTYE
CONSENSUS/80%    .....tu.LstFLlp+uhts..tlup.haWhlhsph......cp.......t.tht.h.p
CONSENSUS/65%    ...hhsSsLspFLlpRAlps..pluphhaWaLps-h......cstph....ptchthlhc
CONSENSUS/50%    ..sapcSsLucFLLcRALsNh.+lGHalaWaL+sEl......+-sch....spRauhlLE


PI3K_ARATH       LLEENI-INWPPGVNG
CONSENSUS/80%    .hhp....t.......
CONSENSUS/65%    thhcsh.spthtthhp
CONSENSUS/50%    saLcsp.spphpshpc

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T