Consensus terms for the PI3Kc domain

ESR1_YEAST       GIMCKK-EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPN
CONSENSUS/80%    .hlhKst-DhRp-.hhhQhhphhpplhtpp....thslth..athlshu.t.Ghlphl.p
CONSENSUS/65%    shlhKssDDLRQDthshQhlplhsplhppp....phcLplpsYpslshuppsGhlEhlss
CONSENSUS/50%    slIaKsGDDLRQDtLshQllplhcclLcp-....plDLplpsYpllssuscsGlIEsVss


ESR1_YEAST       VVTLRSILSTKYESLK------------------------------IKYSLKSLHDRWQH
CONSENSUS/80%    s.shtpl.....................................................
CONSENSUS/65%    stohtpl.....................................................
CONSENSUS/50%    usolppIppt..................................................


ESR1_YEAST       TAVDGKLEFYMEQVD-KFPPILYQWFLENFPDP---------------------------
CONSENSUS/80%    .....................hhpahhpt..s............................
CONSENSUS/65%    .............h..h...slhpahhpp.ss............................
CONSENSUS/50%    .......p.htttssshpsssLtcalpcppssst..........................


ESR1_YEAST       ----------INWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDC
CONSENSUS/80%    ............h.thhppahhShAshshhsYlLtltDRHstNlhls..pGphhHlDFsh
CONSENSUS/65%    ...........ta.puhpsaspShAuhslhsYlLGluDRHssNlhls.psGclhHIDFGh
CONSENSUS/50%    ..........tpahsApcsFl+SsAuYSlloYlLGlGDRHs-NIMlc.psG+lhHIDFGa


ESR1_YEAST       LFEKG-KRLPVP-----------------EIVPFRLTPNLLDALG-------IIGTEGTF
CONSENSUS/80%    hhtp...h.......................sPhhLT.phh.shs........st..t.a
CONSENSUS/65%    hhsps..thhs..................EtsPF+LTpchltshu........othhthF
CONSENSUS/50%    lLusu.ppthsh.................EpsPF+LTp-hlplMG......hsospaspF


ESR1_YEAST       KKSSEVTLALMRKNEVALMNVIETIMYDRNMDHSIQK---------------ALKVLRNK
CONSENSUS/80%    hphs.psh.hhRpp.p.hhphhthhh.ssh..pht..................h...ptt
CONSENSUS/65%    pphCtpuhphlRcptshlhslhphhhtssh.sphptt..............pshthhppp
CONSENSUS/50%    +shCpcuaplLR+ssctllsllslMlsssl.Pchsss.............tcslphlcpp


ESR1_YEAST       IRGID-------PQDGLVLSVAGQT--ETLIQEATSEDNLSKMYIGWLPF---------
CONSENSUS/80%    h............sttph.p.h........h.tt..ts.hs.h...hp.h.........
CONSENSUS/65%    hphp........hscppshphh.t......hhppp.tuhhsph.thhpphtp.......
CONSENSUS/50%    hpls........ho-ccuschhtp......llssshsohhsphpphhcplsph......

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T