Consensus terms for the PIPKc domain

O04095/1-427     RASDFGKNARTKMFFPRDGSNFTPPHKSVDFSWKDYCPMVFRNLRQ--------------
CONSENSUS/80%    ..p..t..phhhh....p..p........paphK.Yhs..Fc.hRp..............
CONSENSUS/65%    t.psaphpcphph.sssp..phpsspt.scFpaKsYsPhsFRtlRc..............
CONSENSUS/50%    pssDFcssc+lphssssc.hchsPscphs-F+aK-YsPhsFRpLR-..............


O04095/1-427     ------------------------------------------MFKLDAAEYMMSICGDDG
CONSENSUS/80%    ..........................................hht.s.tsahhSlstp..
CONSENSUS/65%    ..........................................lhslstt-alhSlspssh
CONSENSUS/50%    ..........................................LFulcccDYlpSLCsssh


O04095/1-427     LTEISSPGKSGSIFYLSHDDRFVIKTLKKSELQVLL-----------------RMLPKYY
CONSENSUS/80%    ....spsGtSGuhFhho.DccallKphp+tEhp.h...................hh.tYh
CONSENSUS/65%    ...hsssGKSGShFahopD-RFlIKplp+pEhphhh.................thh.sYa
CONSENSUS/50%    .hctuSuGKSGShFYlSpDDRFIIKTlp+sElcsLl.................chLscYY


O04095/1-427     EHVGDHE-NTLITKFFGVHRITLKW-------------GKKVRFVVMGNMFCTELKIHRR
CONSENSUS/80%    tph.tp...ThlsphhGhaplp..t..............hch.hllMpNlh..phphpph
CONSENSUS/65%    ppltppp.sTLLsKhaGlaplphts..............h+hchlVMpNLF..chphpph
CONSENSUS/50%    p+lsppc.sTLLsKFFGlaRVpscu.............tpKlcllVMsNLFspclslH++


O04095/1-427     YDLKGSTQGRFTEK------IKIQEKTTLKDLDLA-----YEFHMDKLLREALFKQIYLD
CONSENSUS/80%    aDLKGS.hsR.spp.......p.p...shhD.shh.......hhlt...hphhhppl..D
CONSENSUS/65%    aDLKGSshsRpssp.......ctpspssLKD.shlp....p.lalpstt+phhhpplppD
CONSENSUS/50%    YDLKGSopuRpscc.......+s+spslLKDlDalct..spslalcsptKpsLhcslcpD


O04095/1-427     CSFLESLNIIDYSLLLGLHFRAPGQLNDILEPPNAMSDQESVSSVDVGLTQEHSIPPKGL
CONSENSUS/80%    s.hLtp.tlMDYSLLlGlc.ht......................................
CONSENSUS/65%    sphLpphpIMDYSLLlGlcshpts....................................
CONSENSUS/50%    scFLsuhpIMDYSLLVGIHscssuttpchp.t..tt.tttptptp.s.............


O04095/1-427     LLVTHEPNSVNTAPGPHIRGST-----------------------LRAFSVGEQEVDLIL
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ...............................................s.h..ttt..h.h


O04095/1-427     PGTARLRVQLGVNMPAQAHHKLIEDKEESAT-IELFEVYDVVVYMGIIDILQEYNTKKKV
CONSENSUS/80%    ..........................................hhhGIIDhhppYsh.K+l
CONSENSUS/65%    ............s............................lLalGIIDhlpsYshcKKl
CONSENSUS/50%    .htt...shs.pspc.....................t..pllLYlGIIDILpsYshcKKL


O04095/1-427     EHTCKSLQYDP-----MTISVTEPSTYSKRFVNFLHKVFP
CONSENSUS/80%    EphhKththss.....t..oshpPp.YtpRF.chhpphhh
CONSENSUS/65%    EphhKulthsu.....pplSslsPc.YupRFh-hhsphhh
CONSENSUS/50%    EHsaKolpasG.....coISlVsPcpYucRFp-FlschFh

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T