Consensus terms for the PLAc domain

PA2Y_HUMAN       EVPFIFNQVTEMVLEMSLEVCSCPD---LRFSMALCDQEKTFRQQRKEHIRESMKKLLGP
CONSENSUS/80%    .h......s..s.h......p.ssp....t.u.t.sstEp.ahppRp..h..sh+phlt.
CONSENSUS/65%    hh.h..shssssshs.t.ssCssss.s.lR.u.slsspEppahppRcshhppuh+sFLsp
CONSENSUS/50%    pspsssshssssuYsPshVsCsu-Dhs.lRpusuLSDsEopaLcpRcspTppAlKcFLuc


PA2Y_HUMAN       KNSEGLHSA------------RDVPVVAILGSGGGFRAMVGFSGVMKALYE---------
CONSENSUS/80%    tp.t...ss............pphP.lulhhSGGGhRAMlshuGhhtAh.p.........
CONSENSUS/65%    tssph.soo...........spslPpIulhsSGGGaRAMlsGuGslpAhss.........
CONSENSUS/50%    ssSsshcoS........s.NuS-lPsIAIAsSGGGaRAMluGAGVluAMDsR..tssppu


PA2Y_HUMAN       --SGILDCATYVAGLSGSTWYMSTLYSHPDFPEK----GPEEINEELMKNVSHN------
CONSENSUS/80%    ..uGlLpsusYluGLSGusWhhuslh.ps.hs.p.........sp.h.hp.Sh.......
CONSENSUS/65%    ..uGlLpsuTYlAGLSGusWhhuoLhhpNatshp....t.p-hsp.WthspSlh......
CONSENSUS/50%    .LuGLLQuATYlAGLSGGoWLlGTLAsNNaoolpt...sspEtsslWslscSll...sss


PA2Y_HUMAN       PLLLLTP-----------QKVKRYVESLWKKKSSGQPVTFTDIFGML----IGETLIHN-
CONSENSUS/80%    ...lhhs.    ..    phhcph.ptl.tKpsuG.shohoDlaGhh....lu.shh.s.
CONSENSUS/65%    s.tllhs.    ..    ppacclscsltpKKsAGaslohTDlWG+s....luhshhss.
CONSENSUS/50%    GlpLlpoh    ..    p+ac+ls-uVpsKKsAGFslSLTDIWGRA....LucsLhsuh


PA2Y_HUMAN       ---RMNTTLSSLKE---KVNTAQCPLPLFTCLHVKPDVSELMFADW-VEFSPYEIGM--A
CONSENSUS/80%    ...t.shohSoltp...hhppuphPhPlhss.th..s.p.l.hssh.hEFsPaEhG...s
CONSENSUS/65%    ...shshThSSl+c...hapsuphPhPlhssssphPssshl.hNsh.aEFoPaEhGoa-s
CONSENSUS/50%    .pGGhulTaSSL+-p.phFpNA-hPlPIhVADuRpPGsolIshNsTlFEFoPaEhGoWDs


PA2Y_HUMAN       KYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVS---------
CONSENSUS/80%    thtsFhs.chhGoph..G.sspt.pp...a..hGhhhus.S.LFNphLh...........
CONSENSUS/65%    plssFhsscYlGo+hhsGsslpptpCsssaDshGFhhusSSoLFNphLh...........
CONSENSUS/50%    slsoFssl-YLGSKlsNGssVcKtcClssaDNsGFlsuTSSoLFNcFLL...........


PA2Y_HUMAN       --GSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIH
CONSENSUS/80%    .......sss...ph.t.hhpphlps.SpspsD.u.h..ss.pt.............ahp
CONSENSUS/65%    .....phsoTt..ph.pphhpchlps.SpDpsD.A.assNPappst...........alp
CONSENSUS/50%    ....tppsSTspsohlsplsc+llcDLSsDs-DIAlYsPNPFp-ss...........alp


PA2Y_HUMAN       RMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVA
CONSENSUS/80%    p.h.s.hspps.h.hh-G...........hp.spshPl.PL..lt.pcplD...h.ssss
CONSENSUS/65%    pphsssls-oshl.lVDG...........hpsspslPLhPL..lpppRslDllhslDssu
CONSENSUS/50%    +shousluDSchLsLVDG...........GEDNpNlPLsPL..lpcERcVDVIFAlDuSA


PA2Y_HUMAN       DPDEFERIYEPLDVKSKKIHVVDSGLT--FNLPYPLILRPQRGVDLIISFDFSARPSDSS
CONSENSUS/80%    Ds-.h...htsL.Vpohch.hsppuh....shsaPhl.c.pphlsLhls.c.ohhssDup
CONSENSUS/65%    DsD.haPsGssL.Vpoac+phsspGh....shsaPhlscspshVsLtlsp+.ohassDup
CONSENSUS/50%    DsD-aWPsGsSL.V+TYERplscsGLs...NhuFPYVPDspTFVsLGLos+PSFFGCDus


PA2Y_HUMAN       -------------PPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLK-ECYVFKPKNPDM
CONSENSUS/80%    .............PPhh.hl.st.auh.sp.sh.phs.p..pp.thh.psh.htshts.s
CONSENSUS/65%    .............PPlhhhlsNtcauh.sshst.Khs.sss-Rpuhh.psa.htshsspo
CONSENSUS/50%    NhTsh.....p.hPPLlVYLPNs+auapoNlSThKlshs-s-RcGllpNGaluAThsNsT


PA2Y_HUMAN       EKDCPTIIHFVLANINFRKYKAP--GVPRETEEEKEIADFD
CONSENSUS/80%    .c....hhthlhssl.hRp.pt...shsh.sppppphtsas
CONSENSUS/65%    -css..hhtsVhssIhpRchcs...shohsscpppsFssYs
CONSENSUS/50%    DDss..FlsCVuCAIlpRKhcus..NlTtPoECspCFscYC

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T