Consensus terms for the PROF domain 

S51835/1-134     MSWQTYVDDHLMADIEGQQG---HHLAAAAILGHDG----SVWAQSS-------TFPKFK
CONSENSUS/80%    huWpsYlcp.hhsst.........h.ptAhlhutsu....ssWAtts.......sh.h..
CONSENSUS/65%    MoWpsYVDs.Lsuss.........thptAtlhupDG....slWApss.......sathts
CONSENSUS/50%    MSWQuYVDspLluoG.........plcuAAIlGpDG....uVWAsSu.......sFslss


S51835/1-134     -PEEITNIMKDFDEP--------GHLAPTGLFLGGAKYMVIQGE---------PGAVIRG
CONSENSUS/80%    ...Ehtthhthhpp.........sth.ssGhhltG.KYhhlps..........psp.hhs
CONSENSUS/65%    ..tEhsslsssFps.........sshhssGlhlsGpKYhsl+s..........-sc.lhG
CONSENSUS/50%    ..tElsslsusFcss........sulhuoGlpluGpKYhll+u..........Ds+sIaG


S51835/1-134     KK-------GSGGITIKKTNQALIFGIYEEP-------------------VTPGQCNMVV
CONSENSUS/80%    Kp.......tttGhhhhpTtpsllluhappt...................hpsupssphs
CONSENSUS/65%    K+.......sssGlhhs+TppullIuhYp-s...................hpsGpsspss
CONSENSUS/50%    KK.......GuuGlsls+TsQAllIuhYc-s...................lQPGsssplV


S51835/1-134     EKIGDYLVDQGY
CONSENSUS/80%    tthApYLhp.sh
CONSENSUS/65%    cclA-YLhssGY
CONSENSUS/50%    E+LADYLtssGY

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T