Consensus terms for the RAS domain

rras_mouse       -ETHKLVVVGGGGVGKSALTIQFIQS----YFVSDYDPTIEDSYTKICTVDGIP-ARLDI
CONSENSUS/80%    ..paKlVllGsGGVGKSulTlQhlpt    hFlppYDPTIEDoYpKph.lDsp..shL-I
CONSENSUS/65%    .ppYKlVllGuGGVGKSALTlQFlQs    pFl-cYDPTIEDSYRKpsplDscs.shLDI
CONSENSUS/50%    .c-YKLVVlGuGGVGKSALTIQFlQu    pFV--YDPTIEDSYRKQlsIDscs.shLDI


rras_mouse       LDTAGQEEFGAMREQYMRAGNGFLLVFAIND-RQSFNEVGKLFTQILRVKDR--------
CONSENSUS/80%    LDTAGpcpaoAMR-.Yh+sGpGFllVaulss ppSFpcltthppplhRV+cp........
CONSENSUS/65%    LDTAGQEEaoAMR-pYhRsGpGFllVYSlTs +pSFc-lpph+pQIlRVKDp........
CONSENSUS/50%    LDTAGQEEFSAMR-QYMRoGcGFLLVYSITs RpSF-Elpsa+-QILRVKDp........


rras_mouse       -----------DDFPIVLVGNKADLENQ-RQVLR-SEASSFSASHH--------------
CONSENSUS/80%    ...........pphPhllVGNKsDLpp..R.Vst.p-uppLAppht..............
CONSENSUS/65%    ...........-phPhlLVGNKsDLcpp.RpVop.pEGppLApphs..............
CONSENSUS/50%    ...........-clPlVLVGNKsDLEsc.RpVSs.cEGccLAcpas..............


rras_mouse       -----------------MTYFEASAKLRLNVDEAFEQLVRAVRKY
CONSENSUS/80%    .................s.ahEsSAK.p.slpcsFhpll+tlpt.
CONSENSUS/65%    .................ssFhEoSAKt+hNV--sFapLVRpl++.
CONSENSUS/50%    .................ssFlETSAKpRhNV--AFacLVRcIR+p

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T