Consensus terms for the RPOL8c domain 

RPB8_HUMAN       AGILFEDIFDVKDIDPEAK-----------KFDRVSRLHCESE-SFKMDLILDVNIQIYP
CONSENSUS/80%    t.hlh--IFpVpplDsp.............+ap+VoRl.stSt.p.pMphhLDlNsplYP
CONSENSUS/65%    ttllh-DIFpVpplDPpuh...........Kap+VSRlpspSt.phcMpLhLDlNoplYP
CONSENSUS/50%    sulLF-DIFsVcclDP-GK...........KFDRVSRlpAcSc.shcM-LhLDINSpIYP


RPB8_HUMAN       VDLGDKFRLVIASTLYEDGTLDDGEYN------PTDDRPSRADQFEYVMYGKVYRIEGDE
CONSENSUS/80%    lthsDphpL.lsssLp.ss..s....t.............hh-pa-YlMaGKlY+lpttc
CONSENSUS/65%    lthsDphpLslsosLppsss.spt..p......s.t....ht-paEYlMaGKlY+lptsc
CONSENSUS/50%    lclGDKFsLsIAoTLNpDGssDsG-as......Ptsccs.LADpaEYVMYGKVYRIE-c-


RPB8_HUMAN       TSTEAATRLSAYVSYGGLLMRLQGDANNLHG-FEVDSRVYLLMKK
CONSENSUS/80%    sp.......thYsSFGGLLMtlpGshtplpt.hphDp.laLhh++
CONSENSUS/65%    sp.....hhthYsSFGGLLMtLpGstppLpt.hplDpplaLLh++
CONSENSUS/50%    scs.tu.+lulYVSFGGLLM+LcG-sspL+s.FElDp+lYLLM+K

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T