Consensus terms for the RasGAP domain

CAA85503/1-346   SSSQESPSLRIKARWQSVHIL--PLRAYDNLLETLCYNYL----------PLCEQLEPVL
CONSENSUS/80%    .......sh.hphhh.t.hh.  ..p.hp.hh.hhh.t..  ..........h.hhtthh
CONSENSUS/65%    .tthp.hshplcshhtp.hhh  s.p.hp.hhpLlh.p.t  .........hhthlspls
CONSENSUS/50%    ppssstuolplcsshpscalh  shptYccLlcLlLpsss  .......tplsptLusVs


CAA85503/1-346   NVRDKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDND---------------HLMFR
CONSENSUS/80%    p..thp.hs..hlphh.ppthht.hlp.lh..plp.....................slh+
CONSENSUS/65%    ss.phsphuthLlplatppphhp.hlptlhttElpc.pps...............sslFR
CONSENSUS/50%    ss.stsslAssLVclFpp+spspsaLssLhppElc+sscs...............sTlFR


CAA85503/1-346   GNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCED--SCEVDPQKLGNVS--------
CONSENSUS/80%    t.slssp.hp.hhthhu.t.lp.shpshlpthhpppp...hEls..+.............
CONSENSUS/65%    usoLso+shp.hh+hhutpYLppsLpshlpplhppcc..shEl-Ps+ht...........
CONSENSUS/50%    uNSLAoKsl-pah+lsGspYLpssLcPlLccll-scc..usElDPsKlc...........


CAA85503/1-346   -----NSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA---------
CONSENSUS/80%    ........hppphp.Lh.hhp.hhptlhpS.p.hP..lp.lhttl.phhtt.........
CONSENSUS/65%    .....tpsl-pphppLhthhpplhpsIhsSssphPhsl+.lhpslpphspp.........
CONSENSUS/50%    .....spslEsshcpLhpas-+lacuIlsSssphPhsLRpIh+sLppsspc.........


CAA85503/1-346   ------------QNREA----LADTLISSSIFLRFLCPAILSPSLFNLVSE----YPSPT
CONSENSUS/80%    ............ph.t.......h.hlushlahRFhssAllsPp.htlhtp....p.s.t
CONSENSUS/65%    ............+Fspt...phthtsluuFlFLRFhsPAIloPchFplhsc....p.ssp
CONSENSUS/50%    ............+FPss...slphpuVSuFlFLRFlsPAIlSPctFsLlsc....psssp


CAA85503/1-346   NARNLTLIAKTLQNLANFSK------FGGKEPHMEFM---NEFVDREWHRMKDFLLRISS
CONSENSUS/80%    sp+sLh.luKhlQslush.p........scc.ah..h...p.hh.pphtthhpah.pls.
CONSENSUS/65%    spRsLhhluKslQsluNhsp.......tsKEtahtsh...p.alppphsthtpFLpplsp
CONSENSUS/50%    spRoLsLlAKllQsLANhsp......hsuKEpaMpsh...NsFlcpphssl+cFL-clus


CAA85503/1-346   ESKSG----PEKNADAI-------VDAGKELSLIATYLEEAWTPLLQEKNGN-------K
CONSENSUS/80%    ..........p..tt..............ph...t.hhhtt...lht..t.........t
CONSENSUS/65%    ss........cpsppt.............phthhppllhpp.ttltphtp.........p
CONSENSUS/50%    sspss.....-pspcsh.......h.sst-luslHpllhcpsptl+ctpsp........c


CAA85503/1-346   HPLSNVKSVLSELAECKRRSDNGV
CONSENSUS/80%    t.h.th...h..h.....t....h
CONSENSUS/65%    p.hsphhhhht.ht.sppphstst
CONSENSUS/50%    cplschssphchhshsscchspsp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T