Consensus terms for the RasGEF domain

S30356/1-245     VMDIDYVELARQLTLREFKLYCKITKFACLAKVWGKKSGLSESID----------SITQF
CONSENSUS/80%    hh.hps.plApplohh-hpha.pl...chht.hhttp..................slpth
CONSENSUS/65%    lhphsshclApQLThh-hplapplp..-hlsphhspppptt.t............slpth
CONSENSUS/50%    llslssp-lAcQLTll-acLFpcIs.pEhlsplaspcsppsss............slcph


S30356/1-245     IKASNQLTNFVGYMILRKAD--------------PKKRVQIIRYFIQVADKCRQ-YNNFS
CONSENSUS/80%    hp.hNphs.hl...lh.p.p...............p.RhtllptalplAt.hhp.hpNhs
CONSENSUS/65%    lpthNpls.aVspplltpss...............ppRspllp+aIplApch+p.lpNas
CONSENSUS/50%    lppFNslopWVsspILppss..............sccRAcllp+FIcVAccC+c.LpNFN


S30356/1-245     SMTAIISALYSSPIHRLKKTWEYMNADA----LSNLKNMNKLMNSS---RNFNEYRDVLK
CONSENSUS/80%    ohhulhtuLppssl.RLp.sat.l.tt.....hphhpphpphhp.....tphtthRthlt
CONSENSUS/65%    ShhAlluuLpsssltRLcpTWptlspp.....hphhppLpplhssp...pNappYRphlp
CONSENSUS/50%    SlhAIlouLsoosIpRL+cTWsplssct....p+haccLscLhssp...cNapsYRctLp


S30356/1-245     FIG------------------------------SEPCVPFFGVYLS--DLTFVYHGNPDY
CONSENSUS/80%    th..................................hlPhhshhLp..Dlhhh.ps..sh
CONSENSUS/65%    phs...............................ssslPahGlhLp..DLshlcpusssh
CONSENSUS/50%    shs...............................sPslPFlGlaLc..DLsalcpGssca


S30356/1-245     LYNRT----------------RQVNFAKRAKTSEIV--SGIDRFKT--TGYNFQEV----
CONSENSUS/80%    ht...................thlNhpKhp..hphl..tth..hpp..t..pht......
CONSENSUS/65%    hp...................shlNFpKhpphhpll..pplphhps..pshshp.p....
CONSENSUS/50%    lcp..................shlNFsKhcplscll..sclpphQs..ssYslpss....


S30356/1-245     ---------PEIQKFLDAW-------------FEKCPTID---EQYQISLNLEPRE
CONSENSUS/80%    ....... ...h..hhpt.................h.p.....t.hthShthts..
CONSENSUS/65%    ....... .pplpphhpt..............hp.hspt....p.aphShphEPts
CONSENSUS/50%    ....... .pclpphlps..............lcslscpp...ctYpLSlclEP+s

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T