Consensus terms for the S4 domain

O66484/1-65      RRLDNVVYRL-GFAST--RRQARQLVAHGHVLVNGKKVN---------------------
CONSENSUS/80%    .tlp.hlhp...hh.o..htthpphl.pttlhlstthh......................
CONSENSUS/65%    hRLDhhltph..hsho..+ppspphIppGtVtlNsphsp.....................
CONSENSUS/50%    tRLDplLsct.hhssS..RspAcclIppGpVpVNGcpls.....................


O66484/1-65      -----IPSYLV----EPGDVIEIKEK-------SRDIPFIKENLE
CONSENSUS/80%    .....t.th.l....t.tp.l.h...............hh.t.h.
CONSENSUS/65%    .....psshhl....p.s-hlplpt............thhhptht
CONSENSUS/50%    .....csuhpV....pssDplslpp...........hphltpplp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T