Consensus terms for the SPEC domain

Q13186/1-104     QQLFRDVEDE-ETWIREKE------PIAASTNRG--KDLIGVQNLLK------KHQALQA
CONSENSUS/80%    .th.tphpph..tWhtpht.......hhtptth...ts.tthpth.p......phpthtt
CONSENSUS/65%    ppahpchpph..tWlpctp......thhpspshs..pchpslpthhc......capshpp
CONSENSUS/50%    ppFtc-sc-l.psWls-p-......phlssp-hu..pDlsslcsLl+......+Hcslcs


Q13186/1-104     EI---AGHEPRIKAVTQ-KGNAMVEE-----------------GHFAAEDVKAKL-----
CONSENSUS/80%    ph...tt.t.phptl.t..upphhtt.................t..tt..lttp......
CONSENSUS/65%    -l...pspptplpplpp.huppLhpp.................tt.tstplppch.....
CONSENSUS/50%    -l...sspcsclpslpc.puccLlpp.................sptsuspIpp+l.....


Q13186/1-104     -----------------------------------------HELNQKWE----------A
CONSENSUS/80%    .........................................ttltttap..........t
CONSENSUS/65%    .........................................pplpppap..........p
CONSENSUS/50%    .........................................scLspcWc..........p


Q13186/1-104     LKAKASQRRQDLE
CONSENSUS/80%    l.thhtt+tttLt
CONSENSUS/65%    LpphhtpRpppLp
CONSENSUS/50%    LpctspcRcpcLc

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T