Consensus terms for the TIR domain

3757516/1-164    NYRVFASFHG---------------PDVRKSFLSHFRKQFICN----GITMFDDQKIVRS
CONSENSUS/80%    ..psalsatt.................h..thh..l.pt........tlpha.cp...tt
CONSENSUS/65%    passFlsaps...............tthppphlsplhcthpth....tlslahcs.h.ts
CONSENSUS/50%    paDlFlSFsu...............cslccsalscLtcshpst....plslFtDcphhuu


3757516/1-164    QT-I---APSLTQGIRESKIS--IVILSKNYASSTWCLN--ELLEILKCRED-----IGQ
CONSENSUS/80%    t.........l.ptlppuphh..lhlho.phhps.hsh...Eh..hhp.h........t.
CONSENSUS/65%    th........lhpsIcpS+hh..lhllSpsahpSpaChp..Ehhthhcpt.t.....tth
CONSENSUS/50%    ssht.....pltcuIccS+hs..llllScsYssSsWCls..ELtphhcstpp.....ssp


3757516/1-164    IVMTVFYGVDP----SDVRKQTGEFGTVFNKT----------------------------
CONSENSUS/80%    hll.lhht.......t.h.t..tpht.hh.....................    ......
CONSENSUS/65%    tllslhhps......pphpp.ssphtthhppp..................    ......
CONSENSUS/50%    plIPIhacsss....sclcppssclppshpcs..................    ......


3757516/1-164    --------------------CARRTEKER-------------RNWSQALNVVGNI
CONSENSUS/80%    ......................th.tt................hhtphhh.hs..
CONSENSUS/65%    ....................hhphspppt..............hWppshhthssh
CONSENSUS/50%    ....................htchscccp.............ppWccslpslsst

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T