Consensus terms for the TNF domain

G2707219/1-133   PGQDGAQAGVDGT-------VSGWEEARINSSS--PLRYNRQIGE--FIVTRAGLYYLYC
CONSENSUS/80%    .htclhst...............W.ts.t.t.....tshphppsp..lhl.psGhYhla.
CONSENSUS/65%    .hs+lhspt.t..........htW.sshths.....pshphpssp..LllppsGhYhla.
CONSENSUS/50%    ssAHLlusssspp.......sLsWpsstutuhh...sGhclpcup..LVlspsGLYalYs


G2707219/1-133   QVHFDE----------GKAVYLKLDLLVDGVLA------LRCLEE-FSATAASSL-----
CONSENSUS/80%    ph.ht................hthpl.h.t.t.......h.hh.t...s...........
CONSENSUS/65%    plhap................lphplhhptsph.....tl.lhts.hpsss.s.......
CONSENSUS/50%    QlpFpsptss........slplslsLphpsspt...PtslsLlss.tposstsht.....


G2707219/1-133   ---GPQLRLCQ-VSGLLALRPGSSLRIRT------LPWAHLKAA----PFLTYFGLFQV
CONSENSUS/80%    .....hht.sh..shhh.Lptsppl.lph......st..hlphs.......shauhh.h
CONSENSUS/65%    .....ahppsh..uslhtLptucpl.lps......sp.thlphs.....ttshFGhhhl
CONSENSUS/50%    ...thahcpsa.lGulhpLpsG-cLsVsl......ss.shlchs....sspoaFGlatl

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T