Consensus terms for the TNFR domain

NGFR_HUMAN/3-0   CA---YGYYQDETT----GRCEACR---VCEA---GSGLVFSCQD-KQNTVC
CONSENSUS/80%    C....tta.t..........C..Cp....C.....s.h..t.ss..tpss.C
CONSENSUS/65%    Ct...spapst........tC..Cp...tCts...s.hhhpsCst.ppsshC
CONSENSUS/50%    Cp..tspYsssss.....tpChtCs...pCss...GpshppsCTs.sssTlC

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T