Consensus terms for the TOP1Ac domain

TOP3_YEAST       KSKPTTKYRP-LPLTTVELQKNCARYLRLNAKQSLDAAEKLYQK----------------
CONSENSUS/80%    ppp.tt..s...sa.hspL.ppusphhthsspcshplAQpLa-t................
CONSENSUS/65%    cpc.pppps...PasTssLpp-Asp+hthospcTMplAQcLYEt................
CONSENSUS/50%    ccKccpcpPP.sPFsTSTLQp-Au++LphSA++TMpIAQcLYEp................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ------------------------------------------------------------
CONSENSUS/80%    ............................................................
CONSENSUS/65%    ............................................................
CONSENSUS/50%    ............................................................


TOP3_YEAST       ----------------------------------------------------------GF
CONSENSUS/80%    ..........................................................th
CONSENSUS/65%    ..........................................................uh
CONSENSUS/50%    ..........................................................Ga


TOP3_YEAST       ISYPRTETDTFPHAMDLK------SLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNN
CONSENSUS/80%    loY.RT-o.hhspth......   ....htt.........t..hh.........t.....
CONSENSUS/65%    ITY.RTDSsplspst......   hh.tltp.h.......spthhs.....http.....
CONSENSUS/50%    ITYhRTDSs+lScsuhtt...   shpplsppa.......uppals.....tpsp.....


TOP3_YEAST       NKFKFPRSGSHDDKAHPPIHPIVSLGPE----ANVSPVE----------RRVYEYVAR--
CONSENSUS/80%    ......t.t..tttuH.sIhPs..h........h..t............hplYpLIhcp.
CONSENSUS/65%    ......ptspptppAHcuI+Pot.h.t.....phtpsp...........h+lY-LIh+R.
CONSENSUS/50%    ....h.cpscpspcAHEAIRPTpslssss..hclpcsc...........h+LY-LIa+R.


TOP3_YEAST       ------HFLACCSEDAKGQSMTLVLDWA-------------------------VERFSAS
CONSENSUS/80%    .......hlAs.htss.htp.pl.hph............................hh.tt
CONSENSUS/65%    .......alAsthtsAthpppplplcht...........................pFpsp
CONSENSUS/50%    .......FlASQMscAchcppslplcss.........................ttpFpus


TOP3_YEAST       GLVVLERN------FLDVYPWARWET--------------TKQLPRLEMNALVDIAKAEM
CONSENSUS/80%    thhl...u......ahthh........................l..h..tp..t...hp.
CONSENSUS/65%    uptlh.pG......ahclhs.t..t...............p..LPhlpps-thphhplph
CONSENSUS/50%    GcplptcG......atclastspcp...............cp.LPslpcG-plslpclch


TOP3_YEAST       K--AGTTAPPKPMTESELILLMDTN-------------------GIGTDATIAEHIDKIQ
CONSENSUS/80%    ...tttspss.haopusllp.hcp....................GlGpsuThAphlphl.
CONSENSUS/65%    ...pppTpPPshaTEusLlphh-pt...................GIGpsuTaAsIIpslh
CONSENSUS/50%    p..c+cTpPPsRYTEAoLlctMEcc...................GIGRPSTYAsIIcsLh


TOP3_YEAST       VRNYVRSEKVG--KETYLQPTTLGVSLV
CONSENSUS/80%    pRtYl..ptt.......hhso.hGh.lh
CONSENSUS/65%    pRsYlthcpp......hlhPTphGhtlh
CONSENSUS/50%    cRGYVppcpp......pLhPTclGhsVs

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T