Consensus terms for the TOP1Bc domain 

HI32816_4/1-89   RFSRVVFNEITKNAIKQAFEKPEQ-----LNMDRVNAQQTRRFLDRVVGFMVSPLLWKKV
CONSENSUS/80%    .h.Rh.hpplstpsl.pAhpp.t.......s.shsput.sRph.DhhhGhpho.hhh..h
CONSENSUS/65%    phpRhhFs-lTcpuIppAhcp.pp.....hshshsput.sRphhDhhlGhplo.hlhpph
CONSENSUS/50%    slpRlpFsEIT+cAIccAlcss+c.....lDhsLVsAQtuR+lLDpllGaslSplLpccl


HI32816_4/1-89   A-----------------------------------------------------------
CONSENSUS/80%    t...........................................................
CONSENSUS/65%    p...........................................................
CONSENSUS/50%    p...........................................................


HI32816_4/1-89   ---------------------------------------------------RGLSAGRVQ
CONSENSUS/80%    .....................................................hShGRVQ
CONSENSUS/65%    ...................................................thlSsGRVQ
CONSENSUS/50%    ..................................................tpsLSAGRVQ


HI32816_4/1-89   SVAVKLLVEREREIKAFQ-----PEEYWE
CONSENSUS/80%    sssLthlhpR..thpth.......t.aa.
CONSENSUS/65%    ossLthll-R-pclppFh......ptaap
CONSENSUS/50%    oPsLulll-REcEIcsFh.....scsYap

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T