Consensus terms for the TOP2c domain

GYBR_STRSH/1-6   GLHHLVQELVDNSVDEALAGV------ADRIDVTVLADG-GVRVVDNGRGIPVGMHPVEK
CONSENSUS/80%    GLa+lh.EllsNuhDphhts.......hspIplhlp.pt..lpV.ssG+GlPlthH.p..
CONSENSUS/65%    GLa+lh.EIlsNuhDEthsuh......sspIcVplct-s.tloVhDsGRGIPlshHtptt
CONSENSUS/50%    GLHHLlaEIlDNAlDEAluGa......sspIcVsIcs-s.sIoVpDNGRGIPV-hHpcpp


GYBR_STRSH/1-6   ------RPAVEVVLTVLHAGGKFGGGGYGVSGGLHGVGLSVVNALSTRLSAEIWTD--GH
CONSENSUS/80%    .     h.s.-hlhs.LhsuupasssthpsoGGhpGhGsplsNhhSpphtlpshpp..tp
CONSENSUS/65%    .     h.ssEhlhshLpuGuKFssssa+soGGLpGVGuplsNALSpchpVpstcs..t+
CONSENSUS/50%    .     hsslElIFTpLHAGGKFDssuYKlSGGLHGVGASVVNALSochcVcVp+c..GK


GYBR_STRSH/1-6   RWTQDYRD-GAPTAPLARHEATS---RTGTSLTFWADGDIFETT-----EYSFETLARRH
CONSENSUS/80%    .ahttapp.h..ht..thht.st...cphTplpFhsD.phFt.t.....p...thhtpRh
CONSENSUS/65%    happpapp.tt.hsthchhsssp...csGTplpFhPD.phFpts.....phphphlpcRl
CONSENSUS/50%    pacQsaccsGssssclcltusoc...+cGTcVsFpPDssIFcpst....cashcllp+Rl


GYBR_STRSH/1-6   QEMAFLN-GGLTLTLTDERSSARATAAVDEADSDPTAKTVS----------------YRY
CONSENSUS/80%    hchAhh..pslpl.hpsp........................................h.
CONSENSUS/65%    h-hAhL..pslplplsspc......................................hhh
CONSENSUS/50%    p-lAaLs.+GlcIpLsDcRtsttt.................................ata


GYBR_STRSH/1-6   DGGITDFVVHLNARKGEPAH----------------------------------------
CONSENSUS/80%    .tuhhpalp.h.pstp............................................
CONSENSUS/65%    .sGlpcalphhspspp.ht.........................................
CONSENSUS/50%    psGlc-YVchlscsKcslsp........................................


GYBR_STRSH/1-6   --PSVITIAAEDT-------ERLLSAEIALQWNGQY----TDSVYSYANAIHTHEGGTHE
CONSENSUS/80%    ....hh...t...............h-hshthspt.......p.hSFsNsltT.cGGTH.
CONSENSUS/65%    ...shhh.tpps...........hphElAhphscsh....ttphhSFsNsItThcGGTH.
CONSENSUS/50%    ..pshhstpccss..........hclElAlpao-uh....spsllSFVNsIsTp-GGTHp


GYBR_STRSH/1-6   EGFRTALTTVVNRYAREKRLLRDK---DANLSGEDIREGLTAIISVNVGEP--QFEGQTK
CONSENSUS/80%    phhtptlhphhpphhpp.th..........lp.tpl+pthhshlshhh.pP..tFpuQTK
CONSENSUS/65%    suhpsulscslschsccpphhp......tplpsp-l+pslsshlslhlspP..pF-uQTK
CONSENSUS/50%    sGF+sAls+slN-Yu+Kpphh+pt....sslcucDlREGLsAlISl+Is-P..pFEGQTK


GYBR_STRSH/1-6   TKLGNTEVRTLLQKIVHEHLADWFDRNPNEAVDIVRKAVQAATARVA-----ARKARDLT
CONSENSUS/80%    ppLssptsp.h.....tcth...h..p...tptllpphh..tph+.t......pphpp.t
CONSENSUS/65%    p+Lssppsphhstt.hscph.phh.pss..sptllcchlttsct+ht......+ph+chs
CONSENSUS/50%    cKLuosEs+tsVppllu-phtpaltcNsspAssIl-KllpsAcARts.....t+cs+-ss


GYBR_STRSH/1-6   RR--KGLLETAALPGKLSDCQSNDPA----TSEIFIVEGDSAGGSAKAGRN---PQYQAI
CONSENSUS/80%    t.....hhp.h.h.sKLsDspptsst.....splhlsEGDSAtu.AhtGhs...pph.ul
CONSENSUS/65%    +p...tthpphph.sKLsDssppssp....tspLalsEGDSAsGoAhtGRs...RphQAl
CONSENSUS/50%    R+..psspcptsLsGKLsDAsosssc....psELalVEGDSAGGSAKuGRs...RcaQAI


GYBR_STRSH/1-6   LPIRGKILNVEKARIDKVLQ-NQENQALISAFGTGVHED----FDIAKLRYHKIILMADA
CONSENSUS/80%    hPLRGKllNVpcsphpplhp.NpEltslhthlGhthtpp.....shpph+Yt+lhlMsDt
CONSENSUS/65%    hPLRGKlLNVccuphcclhp.NpEIpslhpslGhshtpp....hslcpLRYt+llIMTDA
CONSENSUS/50%    LPLRGKlLNVcKAshccIlc.NcEIpslIpuLGsGlucc....FclccLRYsKIIIMTDA


GYBR_STRSH/1-6   DVDGQHISTLLLTFLFRFMRPLVEEG--HVHLSRPPLYKIKWSRE---HVEYAYSDRERN
CONSENSUS/80%    DhDGuHIpsLllsFhaphh..Llp.s..alh.h.sPlh+hp.tp........h..ht..p
CONSENSUS/65%    DsDGuHIpsLLlTFha+ah.sLlctG..alalhhsPLaKlphtpt......hhthhphp-
CONSENSUS/50%    DsDGuHI+sLLLTFFaRaMpsLlEpG..alalAlPPLYKlopscp.....tthsahphcE


GYBR_STRSH/1-6   TLLERGRRDGRRIR-DDSIQRFKGLGEMNAEELRVTTMDPDHRVLGQVTLDDAAFAD--D
CONSENSUS/80%    ..t.h.t........thplphYKGLGp.sspphh-hh.s.pp+hhh.h.htst.tt...t
CONSENSUS/65%    hhp.htpp.......phplpRYKGLGEhsspphhEshhs.cp+plhhVtlp-ttps...p
CONSENSUS/50%    hccphpppt....ptsasIQRYKGLGEMsucQLaETTMDP-+RplhpVslcDsscu-..c


GYBR_STRSH/1-6   LFSVLMGEDVEARRHFIQRNAQ
CONSENSUS/80%    h..hh.tccsp.R+palpp.h.
CONSENSUS/65%    lhpshMuccs-.R+paIppss.
CONSENSUS/50%    lhssLMG-+VEsRKcWIpcNss

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T