TOP1_HUMAN LFRGRGNHPKMGMLKRRIM-PEDIIINCSKDAKVPS---PPPGH-KWKEVRHDNKVTWLV CONSENSUS/80% LFRGRGtHPKhGhlK+Rl..spplhINhuK-u.lP....P.sGc.pWtEl+HDspVTWLs CONSENSUS/65% LFRGRGsHPKhGhLK+Rlh.PEDIhINhuKDA.lPp...PPsGH.+WKEVRHDNpVTWLs CONSENSUS/50% LFRGRGsHPKpGpLKRRIh.PEDIlINlGKDA+VPs...PPPGH.KWKEVRHDNcVTWLA TOP1_HUMAN SWTENIQGS-IKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKV CONSENSUS/80% .WpEsIpsp.hKYlhLsssSplKGppDhpKaEpARcL+phlcpIR.ppYpcphcsc.hh. CONSENSUS/65% .WpENIpss.hKYlhLssuSplKGppDhpKYEpAR+LKcpl-pIR.ppYpc-hKSKcMp. CONSENSUS/50% pWsENIsGs.lKYVhLuASSclKGpSDacKYEsAR+LKcaVD+IR.csYp+DaKSK-M+c TOP1_HUMAN RQ--------------------RAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHI CONSENSUS/80% RQ....................hAsAhYhIDhhALRAGNEKt-.-pADTVGCCSL+hEpl CONSENSUS/65% RQ....................+AsAlYhIDpLALRAGNEKsE.-pADTVGCCSLRsEHl CONSENSUS/50% RQ....................RAVAlYLIDKLALRAGNEK-E.DEADTVGCCSLRVEHV TOP1_HUMAN NLHPELDG-----------------------------QEYVVEFDFLGKDSIRYYNKVPV CONSENSUS/80% plp...ph...................................FDFLGKDSIRaapcV.V CONSENSUS/65% sL+Ps.ss...................................FDFLGKDSIRYYNcVpV CONSENSUS/50% sL+PPscl...................................FDFLGKDSIRYYNcV-V TOP1_HUMAN E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------GILNKHLQDL CONSENSUS/80% -..pVFKNlphFhcs............Kp.tDplFDcLso..........shLNpaLpph CONSENSUS/65% -..pVFKNLplFhcs............KpssDDLFDRLsT..........uhLN+HLpsl CONSENSUS/50% E.KcVFKNLplFpcs............KpPuDDLFDRLsT..........SlLNKHLp-L TOP1_HUMAN MEGLTAKVFRTYNASITLQQQLKELTA--------------------------------- CONSENSUS/80% M.GLoAKVFRTYNAShThpp.Lcph.t................................. CONSENSUS/65% M.GLTAKVFRTYNAShThppQLcphps................................. CONSENSUS/50% McGLTAKVFRTYNASITLQ-QLKclss................................. TOP1_HUMAN ----------------------------------------------PDENIPAKILSYNR CONSENSUS/80% ...............................................ptshstKlh.YNp CONSENSUS/65% ...............................................csslspKllsYN+ CONSENSUS/50% ...............................................-uNls-KILuYNR TOP1_HUMAN ANRAVAILCNHQRAPPKTFE-KSMMNLQTKIDAKKEQLA--------------------- CONSENSUS/80% ANRtVAILCNHQRsssKsat.tph.phpp+Icthp.phh..................... CONSENSUS/65% ANRtVAILCNHQRolsKoap.coMt+lppKIcth+.Qhh..................... CONSENSUS/50% ANRsVAILCNHQRoVsKTa-.cSMp+Lp-KIcuhKcQltchp..h.phc........... TOP1_HUMAN ---------------DARR-----------------DLKSA------KADAKV------- CONSENSUS/80% ...............csht.................th+pt......ph..p........ CONSENSUS/65% ...............-shp.................chKst......Khphcs....... CONSENSUS/50% ...............-ucc.................clKSu.tp...Khcucs....... TOP1_HUMAN --------------------------------------MKDAKTKKVVESKKK------- CONSENSUS/80% .......................................t.tcphp....ptK....... CONSENSUS/65% .......................................cptKphch.ppppK....... CONSENSUS/50% ......................................pcccKshKhcpppKK....... TOP1_HUMAN --------AVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWG CONSENSUS/80% ........tlpplpppl.phphphps+--.KplALGTSKlNYlDPRloVsasK+at CONSENSUS/65% ........tlp+lpppl.phclQhpD+--NKplALGTSKlNYlDPRITVAWCKKas CONSENSUS/50% ........tIp+L-E+IpKlElQtpDKEENKplALGTSKlNYlDPRITVAWCKKa-
The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:
| Class | Key | Residues |
|---|---|---|
| alcohol | o | S,T |
| aliphatic | l | I,L,V |
| any | . | A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y |
| aromatic | a | F,H,W,Y |
| charged | c | D,E,H,K,R |
| hydrophobic | h | A,C,F,G,H,I,K,L,M,R,T,V,W,Y |
| negative | - | D,E |
| polar | p | C,D,E,H,K,N,Q,R,S,T |
| positive | + | H,K,R |
| small | s | A,C,D,G,N,P,S,T,V |
| tiny | u | A,G,S |
| turnlike | t | A,C,D,E,G,H,K,N,Q,R,S,T |