Consensus terms for the VPS10 domain

T00348/124-757   SLALARPKSSDVYVSYDYGKSFSKISEKLNFGVGNNSEAVISQFYHSPADNKRYIFVDA-
CONSENSUS/80%    p..lh..t.uphahS.DhGpoa.K...c...s.......hht..atpss...t.......
CONSENSUS/65%    shhlhpspposlYhSpDhGpoa.Kh..ch..G......shlsphassssshhthhh....
CONSENSUS/50%    shsLhpsspSclYlSpDaGcTa.Kph.cs..G.t....sllsshFsssustpsohhl...


T00348/124-757   -------YAQYLWITFDFCSTIHGFSIPFR----AADLLLHSKASNLLLGFDRSHPNK--
CONSENSUS/80%    ........ts.lahopD.utsa.hhplP......h...h.h.tpt.hhhhhttpp.....
CONSENSUS/65%    ........tsplahosDpGpoa.thplPht....h.phh.t.ppsshlhhhspsp.....
CONSENSUS/50%    .......hcuplalTsDcGcoFpphcLPFt....ssphhhasppssalLuaupcs.....


T00348/124-757   -------------------------QLWKSDDFGQTWIMIQEHVKS-----FSWGIDP-Y
CONSENSUS/80%    .........................hhaho.shGppa..h.pth.......h.hs.....
CONSENSUS/65%    .........................hlahop-hGcsap.htcpshp.....hthuhhshs
CONSENSUS/50%    .........................sLYlSpDhGcoWpphp-slss....pauWultshs


T00348/124-757   DQPNAIYIERHEPFG----FSTVLRSTDFFQS--RENQEVILEE---------------V
CONSENSUS/80%    p..phhhhphpt..s.....hhphhps.........s...hh.s...............h
CONSENSUS/65%    spsphlhhpscpssu....htpplhpssshtt....sppslh.s...............l
CONSENSUS/50%    cpsshVpsps+cssu....hspsLhpos-atp...psppslhlc...............l


T00348/124-757   RDFQLRDKYMFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPI-NE--YYIADA
CONSENSUS/80%    hshh.pstahhhth.s........sphphhVo.ptptat.tphPh..sl.pp..hpIhss
CONSENSUS/65%    huhhhpspYlasslhsp.......sphphaVohstssFt.sphPh..sl.cp..apIlsu
CONSENSUS/50%    suatlpscYlFlsVssc......sochphaVShctssFstAchPpt.sls+cphapIlso


T00348/124-757   AEDQVFVCVSHS--------NNSTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYF
CONSENSUS/80%    pcsplFhtltp.........pshsslhhSsspGhhFsh..tsh...p.............
CONSENSUS/65%    s-splFltVsc..p......sshusLhhS-scGhpFsh..cslppsss............
CONSENSUS/50%    sEspVFlsVucstp......scsuNLapSDocGlpFohuhcNVppsos............


T00348/124-757   ANEPFADFHRVEGLQGVYIATLINGSM----------NEENMRSVITFDKGGTWEFLQAP
CONSENSUS/80%    ....hh-h.plpulcGlhlsshhs..............cpphpohITaspGtsWphLpss
CONSENSUS/65%    ....alDFhcVpGlcGlhlsshls..............-pplpThITFscGtcWshLpsP
CONSENSUS/50%    ..t.alDFpcVpGL+GlaIANlls.pc..........tDcplcThITFDcGu-WsaL+sP


T00348/124-757   AFTGYGEKINCELSQG--CSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNL
CONSENSUS/80%    t.s......tCp......CpLpLth.hs......h..h..hspptu.uhhhssGphust.
CONSENSUS/65%    sps..sp.hpCs.sth.pCSLHLHh.ho....p.hp.hshtopssAsGlhhusGslGsph
CONSENSUS/50%    cs-.pGc.hsC-hsshppCSLHLHhcao....pphsptshtSpsoAsGlllusGslGssL


T00348/124-757   AS---KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQG-----METNELKYSTN
CONSENSUS/80%    h....p.psalopDuG.oWpphhct.a.athhD.Gullhhl.pts......hs.lhaShD
CONSENSUS/65%    h....c.ssalSsDuGhoWpphhcusHhatahDaGGllVAltpsu......hsplpYShD
CONSENSUS/50%    lsp..-sssFISoDGGtTW+clh-GPHhasauDaGGIIVAlccsu.....sssplpYSsD


T00348/124-757   EGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTI-FGSNKESV-HSWLILQVNATDALGVP
CONSENSUS/80%    pGpoWppapFstp.lhh.slho.Pstpshhhhl.hGp.tp...tpa.hhplDapshhtpp
CONSENSUS/65%    cGcTWpsYsFsps.lhlpslhocPstcothhhl.aGphtph..ssahhhplDFcslhp+p
CONSENSUS/50%    EG+TWpcYsFopcslhVcGllTEPGccoslhoL.FGcsppps.usWplaslDF+slFcRp


T00348/124-757   -CTENDYKLWSPSDERG--------NECLLGHKTVFKRRTPHATCFNGE-DFDRPVVVSN
CONSENSUS/80%    .Ct.pphp.hp.t..............ClhGtpp.ahR+p.pthChss....shsh..ps
CONSENSUS/65%    .CpccDappWpssptp.........ptClhGpKp.FhR+pspupChssp..hshshssps
CONSENSUS/50%    .CpE-DYssWpssspcs........ssClhG+KppF+RR+scupChsGc.pa-huhssss


T00348/124-757   CS-CTREDYECDFGF-KMS-EDLSLEVCVPDPE--FSGKPYSPPVPCPVGSSYRR---TR
CONSENSUS/80%    C..CoptDa-CDasa.+...tp.....Ch.s.......p.......C.htpth.....o.
CONSENSUS/65%    Cs.CTcpDFECDasF.+...pc.o...Ch.s.t..h.us.....t.Cthspshpp...ot
CONSENSUS/50%    Cs.CTcpDFECDaGFhRsu.u-ho...Clss.t..hhuc..ssschCshGpshpc.hpos


T00348/124-757   GYRKISGDTCSGG-DVEARLEGELVPCP
CONSENSUS/80%    GYRKlshspCpsG..hp.phts....Cs
CONSENSUS/65%    GYRKlsuspCpGG..lchchpsh.hsCP
CONSENSUS/50%    GYRKIPGssCpGG..lchcssst.psCP

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T