Consensus terms for the VWA domain

CA1E_CHICK/1-18  KAD-LVFLVD--GSWSIG-------------------------------DDNFNKIISFL
CONSENSUS/80%    .hs.lhhllD...Stsh.................................t.ht.hhthh
CONSENSUS/65%    .hc.lhhllD..sStSht...............................tpphpthpphl
CONSENSUS/50%    ttD.lllllD..sSsShs...............................pspasps+shl


CA1E_CHICK/1-18  YSTVGALDKI-------------------------GPDGTQVAIIQFSD-----------
CONSENSUS/80%    .thhpth...............................tsphslh.ast...........
CONSENSUS/65%    tpllpphph.............................psplulltaus...........
CONSENSUS/50%    ppllpplsht...........................pss+lullsFus...........


CA1E_CHICK/1-18  -DPRTEFKLN-------------------------AYKTKETLLEAIQQIAY--------
CONSENSUS/80%    .t.t..h.h.............................phtth.phltth..........
CONSENSUS/65%    .psphhhsh...........................hpshpplhptlpphp.........
CONSENSUS/50%    .sspshhslp.........................ptpstssltpslpslph........


CA1E_CHICK/1-18  -----------------------------KGGNTKT-GKAIKHAREV-------------
CONSENSUS/80%    ..............................tt.s.h.stulthshp..............
CONSENSUS/65%    .............................hsssoph.stulphshp..............
CONSENSUS/50%    .............................suusTsh.usALptuhcp.............


CA1E_CHICK/1-18  ------LFTGEAGMRKGI------------PKVLVVITDGRSQD----------------
CONSENSUS/80%    ...........tt.t................thhllhosu..t.................
CONSENSUS/65%    ........ttttstpt...............phlllloDGpss.................
CONSENSUS/50%    ......hhptppuscstt............tclllllTDGpsss................


CA1E_CHICK/1-18  ---------------------------------DVNKVSREMQLDG----FSFFAIGVAD
CONSENSUS/80%    .................................t..t....htp.t....h.hhslshtt
CONSENSUS/65%    .................................phtpsstthppts....ltlhsluhsp
CONSENSUS/50%    ................................tcspcsspph+css....lplhslGlus


CA1E_CHICK/1-18  A----------DYSELVNIGSKPSERHVFF--VDDFDAFTKIEDELITFVC
CONSENSUS/80%    .............t.ht.lst........................h.t...
CONSENSUS/65%    t..........shttlptlsststt.............h.p.htthhphhh
CONSENSUS/50%    s..........spspLcplusssssth........h.thssttpplssphp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T