Consensus terms for the WNT1 domain

WN5_HUMAN/1-34   QLAGLSQ---GQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVD---NTSVF
CONSENSUS/80%    ph.tLs....tQhphspt..thh..lttGsp.uhpECpaQF+.pRWNCsths......hh
CONSENSUS/65%    pl.uLst...pQhphC+p..-hh.slspGup.ulcECQaQFRtcRWNCoshs......lF
CONSENSUS/50%    sltGLss...+QpplC+sps-lMtoVucGAQpGIcECQaQFRpRRWNCSTls....pslF


WN5_HUMAN/1-34   GRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLP----------
CONSENSUS/80%    t.hlp.usREsAFhaAIouAuVsaslspuCtpGphttCuCs.p.ps..............
CONSENSUS/65%    GpllppuoREoAFlaAIoSAGVsauloRuCupGplpsCGCstphpG..............
CONSENSUS/50%    G+lLppGoREoAFlYAISSAGVuaAVTRACopGsLcsCGCDpp++G..............


WN5_HUMAN/1-34   -----------RDWLWGGCGDNIDYGYRFAKEFVDARERER-----------IHAKGSYE
CONSENSUS/80%    ...........tsa.WGGCu-sltaG.hhu+tFsDs.cp.....................
CONSENSUS/65%    ...........psWpWGGCSDslcaGhthu+pFVDutEp...................tt
CONSENSUS/50%    ........ssscuWcWGGCSDNI-aGhtFS+cFVDApE+...................tp


WN5_HUMAN/1-34   SARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDS
CONSENSUS/80%    sh+thMNhHNNEAGRhsl.pthc.pCKCHGhSGSCph+TCWhthspFRplGthL+c+ast
CONSENSUS/65%    ssRthMNLHNNEAGRpslhpph+hcCKCHGlSGSCsl+TCWhphPsFRclGshLK-Kacu
CONSENSUS/50%    cARsLMNLHNNEAGRpuVpspM+pECKCHGVSGSColKTCWhpLPsFRcVG-hLK-KYDu


WN5_HUMAN/1-34   AAAMRLNSRGK----------------------LVQVNSRFNSP-----TTQDLVYIDPS
CONSENSUS/80%    A.ph.h.p................................hp.......ttpDLlYh-.S
CONSENSUS/65%    Asclhhsptst......................h.stspth+s......sppDLVYh-sS
CONSENSUS/50%    AscVcls+tupt....................tLsscsspaKsP.....ocpDLVYlEsS


WN5_HUMAN/1-34   PDYCVRNEST-GSLGTQGRLCNKTSEGMD-----GCELMCCGRGYDQF--KTVQTERCHC
CONSENSUS/80%    PsaC..s.th.G..GTtGR.Cs.su.shs.....uCchhCCGRGap.p..p..hhppCpC
CONSENSUS/65%    PsaCt.s.ps.G.hGTpGRtCNpoS.uhD.....GC-LhCCGRGapsc..p.phhc+CpC
CONSENSUS/50%    PDFCccNscs.GohGTpGRtCNpTSculD.....GC-LMCCGRGYcTc..pscllE+CsC


WN5_HUMAN/1-34   KFHWCCYVKCKKCTEIVDQFVCK
CONSENSUS/80%    pFpWCC.VpCppCpphh.hahCh
CONSENSUS/65%    +FHWCChVpCppCpchhphahCt
CONSENSUS/50%    KFHWCCaVKCcpCpcpl-lHsC+

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T