Consensus terms for the eIF2B_5 domain

IF2B_METTH/10-   TKRFEVPKAYSVIQGN-----RTFIQNFREVADALNRDP-----QHLLKFLLRELGTAGN
CONSENSUS/80%    h.+h.h....hhhtG......+T.h.Nh.-lscthtR.s.....pahhpahhtElGstsp
CONSENSUS/65%    hhRaphP..pshhEGp....hKTlhhNhh-ls+slpRss.....palhcalhsELGopus
CONSENSUS/50%    ppRacMPsPplh+EGp....hKTllsNFsDIAKsLsRsP.....cHlhKFLhsELGTsGo


IF2B_METTH/10-   LEG--GRAILQGKFTHFLINERIEDYVNKFVICHECNRPDTRIIRE--GRISLLKCE---
CONSENSUS/80%    h-tt.tphllpGtap.tphtshlctalppaVhC.tCts.-T.l.hp..pphh.hpCt...
CONSENSUS/65%    lDsp.tchllpGcastpplpslLctaIccYVhChsCpsP-TpLhcc..schhhLcCc...
CONSENSUS/50%    lDup.sRLllpG+FsscclpslLccYI+cYVhCtsCcSPDTcLpK-..sRlahL+Cc...


IF2B_METTH/10-   -------------ACGAK
CONSENSUS/80%    .............sCG..
CONSENSUS/65%    .............uCGup
CONSENSUS/50%    .............ACGup

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T