Consensus terms for the small_GTPase domain

rras_mouse       -ETHKLVVVGGGGVGKSALTIQFIQS----YFVSDYDPTIEDSYTKICTVDGIP-ARLDI
CONSENSUS/80%    ..paKlVllGsGGVGKSulTlQhlpt    hFlppYDPTIEDoYpKph.lDsp..shL-I
CONSENSUS/65%    .ppYKlVllGuGGVGKSALTlQFlQs    pFl-cYDPTIEDSYRKpsplDscs.shLDI
CONSENSUS/50%    .c-YKLVVlGuGGVGKSALTIQFlQu    pFV--YDPTIEDSYRKQlsIDscs.shLDI


rras_mouse       LDTAGQEEFGAMREQYMRAGNGFLLVFAIND-RQSFNEVGKLFTQILRVKDR--------
CONSENSUS/80%    LDTAGpcpaoAMR-.Yh+sGpGFllVaulss ppSFpcltthppplhRV+cp........
CONSENSUS/65%    LDTAGQEEaoAMR-pYhRsGpGFllVYSlTs +pSFc-lpph+pQIlRVKDp........
CONSENSUS/50%    LDTAGQEEFSAMR-QYMRoGcGFLLVYSITs RpSF-Elpsa+-QILRVKDp........


rras_mouse       -----------DDFPIVLVGNKADLENQ-RQVLR-SEASSFSASHH--------------
CONSENSUS/80%    ...........pphPhllVGNKsDLpp..R.Vst.p-uppLAppht..............
CONSENSUS/65%    ...........-phPhlLVGNKsDLcpp.RpVop.pEGppLApphs..............
CONSENSUS/50%    ...........-clPlVLVGNKsDLEsc.RpVSs.cEGccLAcpas..............


rras_mouse       -----------------MTYFEASAKLRLNVDEAFEQLVRAVRKY
CONSENSUS/80%    .................s.ahEsSAK.p.slpcsFhpll+tlpt.
CONSENSUS/65%    .................ssFhEoSAKt+hNV--sFapLVRpl++.
CONSENSUS/50%    .................ssFlETSAKpRhNV--AFacLVRcIR+p



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rho2_yeast       LVIIGDGACGKTSLLYVFTLGKFPEQYHPTVFENYVTDSRV-------------------
CONSENSUS/80%    hVlVGDGusGKTslLhsaspstFPptYlPTVF-Nasssh.h...................
CONSENSUS/65%    hVlVGDGulGKTsLLlsaopstFPppYlPTVF-NYssslhh...................
CONSENSUS/50%    lVVVGDGAVGKTCLLIsYTsssFPc-YVPTVFENYsuslpl...................


rho2_yeast       -----------DGIKVSLTLWDTAGQEEYERLRPFSYSKADIILIGFAVDNFESLINART
CONSENSUS/80%    ...........ssp.lpLsLWDTAGQE-Y-pLRPLSYspsslhLlCFulss.sShpNltp
CONSENSUS/65%    ...........-sc.lpLuLWDTAGQE-YDRLRPLSYPpoDVhLlCFSlss.sSh-Nlpp
CONSENSUS/50%    ...........Du+slpLuLWDTAGQEDYDRLRPLSYPsoDVFLlCFSVsoPsSF-NVpc


rho2_yeast       KWADEALRYCPDAPIVLVGLKKDLR-----QEAHFKENAT-DEMVPIEDAKQ--------
CONSENSUS/80%    KWhsElpcasstsshlLVGs+hDhR .......t.htphpt.t...hp............
CONSENSUS/65%    KWhPElp+asPssPhlLVGsKhDLR ....tc.pslpplpppp.pPlo.ppu.t......
CONSENSUS/50%    KWhPEVpHaCPssPllLVGTKtDLR ....sDpsslccLpcpcppPlTsppGpt......


rho2_yeast       ---------------VARAIGAKKYMECSALTGEG-VDDVFEVATRTSLLM
CONSENSUS/80%       ............hsppltAhtYhECSAhppps.lpplFptAhhhsh..
CONSENSUS/65%       ............hA+cItAhpYlECSAhTpps.lcpVFctAlcsslp.
CONSENSUS/50%       ............lAKcIGAhpYlECSALTpcG.l+pVF-cAl+usLps



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P28746           VGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGL
CONSENSUS/80%    VGDGGTGKTTFVKRHLTGEFEKKY.sTlGVEVHPLsFaTNpG.I+F.sWDTAGQEKFGGL
CONSENSUS/65%    VGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGpIRFNVWDTAGQEKFGGL
CONSENSUS/50%    VGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGpIRFNVWDTAGQEKFGGL


P28746           RDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKS
CONSENSUS/80%    RDGYYIpuQCAIIMFDVTuRlTYKNVPsWHRDLsRVCENIPIVLCGNKVDlKsRpVKAKp
CONSENSUS/65%    RDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLsRVCENIPIVLCGNKVDVKDRKVKAKo
CONSENSUS/50%    RDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLsRVCENIPIVLCGNKVDVKDRKVKAKo


P28746           IVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAA
CONSENSUS/80%    lsFHRKKNLQYY-ISAKSNYNFEKPFLaLARKLhGD.NLcFVt.PALAPPEV.hD.Ah.s
CONSENSUS/65%    ITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLlGDPNLEFVAMPALAPPEVpMDPAhtA
CONSENSUS/50%    ITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLlGDPNLEFVAMPALAPPEVpMDPAhtA


P28746           QYEHDLEVAQTTALPD-EDDDL-
CONSENSUS/80%    p.EtDLtsAtttsLPD.-DDsh.
CONSENSUS/65%    cYE+DL-sAAsssLPD.DDDDL.
CONSENSUS/50%    cYE+DL-sAAsssLPD.DDDDL.



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HSU237H1_1-177   LKFLLVGDRDVGKSEILESLQDGTAESPYS-HLGGIDYKTTTILL----------DGQRV
CONSENSUS/80%    hKllllG-suVGKoslh.paspspF..p...sTlGl-Ft.+.lph..........psphl
CONSENSUS/65%    aKlllIGDSGVGKosLltRFscspFstp.t.sTIGV-Fts+plpl..........cu+pl
CONSENSUS/50%    FKlllIGDSGVGKSsLLsRFscscFssppp.uTIGVDFpsKslpl..........-GKcV


HSU237H1_1-177   KLKLWDTSGQGRFC-TIFRSYSRGAQGVILVYDIANRWSFEGMDR-WIKKIEEHAPG---
CONSENSUS/80%    +hQlWDTAGQERap.slstuYYRsA.uhlllYDlopttoFppltp.Whp-hp.hss....
CONSENSUS/65%    KlQIWDTAGQERFR.olTsuYYRGAhGsllVYDlTpcpoFpslpp.Wlc-lcpauss...
CONSENSUS/50%    KLQIWDTAGQERFR.olTsuYYRGAsGslLVYDITc+sSF-slpp.WlcElcpauss...


HSU237H1_1-177   --VPKILVGNRLHLAF----KRQVPREQAQAY-------------AERLGVTFF-EVSPL
CONSENSUS/80%    .sh.hhLlGNK.Dhtp  ...+tVs.pputth.............upp.th.ah.EsSAh
CONSENSUS/65%    .shshhLlGNKsDlpp  ..pRtVsp--upth.............Acctsh.ah.ETSAp
CONSENSUS/50%    .sllllLVGNKsDLcc  ..pRsVopEEAppa.............AccpulhFh.ETSAK


HSU237H1_1-177   CNFNIIE---SFTELARIVLLR
CONSENSUS/80%    ps.sVpp...sF.tlhpplht.
CONSENSUS/65%    sshNVpp...uFpplspclhpt
CONSENSUS/50%    supNV-p...AFpplsccIhpp



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sar1_yeast       FGWFRDVLASLGLWNKHGKLLFLGLDNAGKTTLLHMLKNDRLATLQPTWHPTSEELAIGN
CONSENSUS/80%    hsWFhshLA.LGLhpKcuKhLFLGLDNAGKTTLLHMLKs-RLs.hQPT.HPTSEELuIGp
CONSENSUS/65%    FsWFYDlLASLGLWNKHAKlLFLGLDNAGKTTLLHMLKNDRLAshQPThHPTSEELAIGN
CONSENSUS/50%    FsWFYDlLASLGLWNKHAKlLFLGLDNAGKTTLLHMLKNDRLAshQPThHPTSEELAIGN


sar1_yeast       IKFTTFDLGGHIQARRLWKDYFPEVNGIVFLVDAADPE--RFDEARVELDALFNIAELKD
CONSENSUS/80%    l+FpsFDLGGH..ARRlW+DYascVsulVaLVDshD.E  RhsEu+hELDALhs.ttLtp
CONSENSUS/65%    IKFTTFDLGGHQQARRLWKDYFPEVNGIVYLVDAsDhE  RFuESKsELDALLuhEELAc
CONSENSUS/50%    IKFTTFDLGGHQQARRLWKDYFPEVNGIVYLVDAsDhE  RFuESKsELDALLuhEELAc


sar1_yeast       VPFVILGNKIDAPNAVSEAELRSALGLLNTTGSQRIEG-----QRPV----------EVF
CONSENSUS/80%    VPFlILGNKIDhP.AhSEsEL+.tLGLhphT.............+sl..........EVF
CONSENSUS/65%    VPFLILGNKIDAPsAlSEDELRuALGLhNTTsupth.s.....sRPV..........EVF
CONSENSUS/50%    VPFLILGNKIDAPsAlSEDELRuALGLhNTTsupth.s.....sRPV..........EVF


sar1_yeast       MCSVVMRNGYLEAFQWLSQYI----
CONSENSUS/80%    MCSlVh+.GYhEuFpWLuQYl.   
CONSENSUS/65%    MCSVVhRpGYGEGFKWLSQYI.   
CONSENSUS/50%    MCSVVhRpGYGEGFKWLSQYI.   



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arf6_chick       ----MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN
CONSENSUS/80%    ....huplhptlFGpKEMRILMlGLDuAGKTTlLYKLKLGp.lTTIPTlGFNVETVpYKN
CONSENSUS/65%    MG.hhuKLFSsLFGNKEMRILMVGLDAAGKTTILYKLKLGElVTTIPTIGFNVETVpYKN
CONSENSUS/50%    MG.hhuKLFSsLFGNKEMRILMVGLDAAGKTTILYKLKLGElVTTIPTIGFNVETVpYKN


arf6_chick       VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRD--RIDEARQELHRIINDREMRD
CONSENSUS/80%    lpFsVWDVGGQD+IRsLWRHYapsTpGlIFVlDssDRp  RlsEARp.h.Rhls-cEhRs
CONSENSUS/65%    ISFTVWDVGGQDKIRPLWRHYYpNTQGLIFVVDSNDR-  RIsEAREELpRMLNEDELRD
CONSENSUS/50%    ISFTVWDVGGQDKIRPLWRHYYpNTQGLIFVVDSNDR-  RIsEAREELpRMLNEDELRD


arf6_chick       AIILIFANKQDLPDAMKPHEIQEKLGLTRIR------------DRNW----------YVQ
CONSENSUS/80%    AlhLlFANKQDLPpAMpstEIp-KLGLpplR            pRsW          alQ
CONSENSUS/65%    AVlLVFANKQDLP-AMsAAEITEKLGLHSIR            cRNW          YIQ
CONSENSUS/50%    AVlLVFANKQDLP-AMsAAEITEKLGLHSIR            cRNW          YIQ


arf6_chick       PSCATTGDGLYEGLTWLTSNYKS--
CONSENSUS/80%    soCAToG-GLYEGLpWLosph+s..
CONSENSUS/65%    uTCATSGDGLYEGL-WLSNNLKNQp
CONSENSUS/50%    uTCATSGDGLYEGL-WLSNNLKNQp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T