cov pid 1 [ . . . . : . . . 80 1 MOEH_DROME/1-20 100.0% 100.0% SPKALNVRVTTMDAE---------------------LEFAIQ-STTTGKQLFDQVVKTIGL---------REVWFFGLQY 2 PTN4_HUMAN/1-19 95.1% 28.8% QHTEVVCNILLLDNT--------------------VQAFKVN-KHDQGQVLLDVVFKHLDL---------TEQDYFGLQL 3 41_HUMAN/1-196 94.7% 28.0% KHRNMHCKVSLLDDT--------------------VYECVVE-KHAKGQDLLKRVCEHLNL---------LEEDYFGLAI 4 E1358784/1-205 97.1% 56.4% QPKTFTVRIVTMDAE---------------------MEFNCE-MKWKGKDLFDLVCRTLGL---------RETWFFGLQY 5 TALI_MOUSE/1-23 95.6% 17.8% RKKQRPLKIRMLDGT--------------------VKTIMVD-DSKTVTDMLMTICARIGI---------TNHDEYSLVR 6 Q20307/1-207 96.1% 43.3% NTKPIYAKVSTMDAD--------------------LEKIVIE-KTWTGRHLFEAVCRIIGL---------RETWYFGLQF 7 NBL4_MOUSE/1-20 95.6% 29.4% VPEEFYCEVLLLDESKL---------------TLTTQQQGIK-KSTKGSVVLDHVFRHINL---------VEIDYFGLRY 8 Q22860/1-259 95.6% 15.7% KRKIRLLKVRMLDGA--------------------VKTISVD-ESQPVSQLMMTVCNKIGI---------SNYEEYSLVR 9 PTN3_HUMAN/1-19 95.1% 27.4% TRSEVICSIHFLDGV--------------------VQTFKVT-KQDTGQVLLDMVHNHLGV---------TEKEYFGLQH 10 Q24440/1-197 94.7% 28.8% HGKPALARVTLLDGS--------------------LLDVSID-RKAIGRDVINSICAGLNL---------IEKDYFGLTY 11 Q24564/1-209 97.6% 50.0% KNRSLSVRVSTFDSE---------------------LEFKLE-PRASGQDLFDLVCRTIGL---------RESWYFGLQY 12 Q14840/1-481 98.5% 9.6% TPQHKLLRLQLPNMK--------------------YVKVKVN-FSDRVFKAVSDICKTFNI---------RHPEELSLLK 13 Q64512/1-214 96.6% 24.4% EDQRRKVNIRLLSGQ--------------------RLELTCD-TKTICKDVFDMVVAHIGL---------VEHHLFALAT 14 Q18685/1-525 98.1% 8.9% TPMHKEARIQLPDMQ--------------------MIDARVD-FSVNSFKATKKLCRDLGI---------RYSEELSLKR 15 P91433/1-193 93.2% 28.5% TKKFVQCKVLLLDGA--------------------HLNIVVP-RNAVGSELYEEVFYSLDL---------EERDYFGLQY 16 D1025178/1-195 94.2% 27.5% SGKLVSIKIQMLDDT--------------------QEAFEVP-QRAPGKVLLDAVCNHLNL---------VEGDYFGLEF 17 Q24796/1-203 95.6% 45.8% KNKTNKVRVTTAESQ---------------------LEFEMQ-KGSLGQDLFDQVVRTIGL---------REVWYFGIQY 18 E1344361/1-202 93.2% 24.1% PPNQIRCTVTFLDST--------------------SYHFEIE-KNSLGIVLLEKVFNYLEI---------IEKDYFGLVF 19 PTNF_MOUSE/1-20 98.5% 28.0% SKSCLVARIQLLNNE--------------------FVEFTLS-VESTGQESLEAVAQRLEL---------REVTYFSLWY 20 PTNE_MOUSE/1-20 98.5% 26.1% SKNCFVARIRLLDSN--------------------VIECTLS-VESTGQECLEAVAQRLEL---------RETHYFGLWF 21 3875752/1-201 95.6% 23.3% DSKMQLAKVLLPDGV--------------------QKEFEVN-KNSEGEALFRQVTRDLSI---------EEREYFSLCF 22 P91092/1-200 95.6% 22.0% SPKDVRCNVHLLHDS-------------------DIIGNEFP-RTQSAQTILDYVCQLKHI---------QEKDFLGLRY 23 O17905/1-219 95.6% 22.4% RGRLVCIKVRMLDDTVAVFHLGVICFFFCVVSFHGTYVFLLQ-HKAIGQTLLDEVCRHLNL---------LECDYFGLSF 24 D1035494/1-195 94.2% 26.6% QEKHLHLRVKLLDNT--------------------MEIFDIE-PKCDGQVLLTQVWKRLNL---------VECDYFGMEF 25 Q13402/1-218 96.6% 17.3% KTTQIFHKVYFPDDT--------------------DEAFEVE-SSTKAKDFCQNIATRLLL---------KSSEGFSLFV 26 TALA_DICDI/1-19 94.2% 18.8% KKKHRPQKFKLLDGT--------------------IKTQLVD-ESQNVSEIVNSICKKMGI---------KNPEEYSLMN 27 O77433/1-227 99.5% 14.9% HSLPHAIPVHMMNST--------------------YQVVSFD-GSTTIEEFQATLAHELGT--------RDATNGFCLFS 28 EXPA_DROME/1-28 98.5% 14.3% SPGSRFLALRLLGQQQ-----------------PKTLYFLVD-AKSRVREVYTQTCLHFAT------QGMLDTELFGLAV 29 WORM|CE18186|T0 96.6% 19.3% RVEDTEVVVELLNGQ--------------------KVEVACR-SDVISRDVFSLIVQNMNI---------NEHVFFGLSF 30 P91443/1-220 97.1% 13.7% KTTQIFHKVFFPDNT--------------------DEAIEVD-SATRARDFCHKIGYRLGL---------KSSDGFSLFV 31 O57612/1-253 95.1% 9.5% PSPTFGLEIHFYTPYV------------------HQLEYLSG--CYTAEELCVEAARKCSI-------SPLCHNLFALYD 32 O93596/1-234 92.7% 12.9% SGAALQVRLYCCRDEA------------------GVISYPAG--EYTAEELSVTAAKQCGV-------SPVHCALFGLMR 33 O24147/1-225 98.1% 16.6% TGKKLTTIVFFLDET--------------------FEEITYD-MATTVADAIEEVAGIIKL---------SAHASFSLFE 34 A39577/1-255 96.1% 11.0% PEPGVEVIFYLSDRE--------------------PLRLGSG--EYTAEELCIRAAQACRI-------SPLCHNLFALYD 35 G3790763/1-249 100.0% 16.1% PLLPNVLRVYLENGQ--------------------TRSFKYD-QSTTVKQILESILEKLQI---------SAKSHFSLAV 36 Q13402_1/1-216 95.6% 18.2% SKKPIMLPVTFMDGT--------------------TKTLLTD-SATTAKELCNALADKISL---------KDRFGFSLYI 37 JAK2_RAT/1-238 94.2% 12.0% KQTEPVLQVYLYHSLGQA--------------EGDYLKFPNG--EYVAEEICVAASKACGI-------TPVYHNMFALMS 38 P91443_1/1-215 96.1% 17.9% SQKPVVLAVTFMDGS--------------------VKTLCAD-SATTAAELCKQLAEKVGL---------TNSFGFSLYI 39 O15032/1-223 97.1% 14.5% --MPNVLKVYLENGQ--------------------TKSFRFD-CSTSIKDVILTLQEKLSI---------KGIEHFSLML 40 D1035500/1-263 96.1% 12.9% HRQEMTSTVYCHGGG--------------------SCKITIN-SHTTAGEVVEKLIRGLAM--------EDSRNMFALFE 41 E1354398/1-223 95.6% 16.4% RPGQTFVSVQTLTKE--------------------SFHVAIS-SKTKVHDVLWKCGERLSL---------SDDKLFGLAF 42 O42291/1-238 95.1% 10.5% SSEPGTLQVYLYHRGPHAP-----------PDSAATLTFTFG--EYTAEELCVHAAKACGV-------LPICHPLFALAT 43 Q91563/1-228 99.0% 13.9% GAIERVLRVFHYFESNNE-------------PATWSSNIRHG-DATDVRGIIQKIVDSHKV---------KNVASYGLRL 44 JAK1_CYPCA/1-25 95.6% 9.8% VMKGLEIHFYLPDTH--------------------QLEYFKD--CHTAEDLCVEGCQEDAT------SHLCADNLFALSE 45 Q20456/1-219 93.7% 14.7% GCQLRRQAFYISKDH--------------------NVSQTLR-PITVAEEMIQELCNLLNV------RSLHEQQEFSLCY 46 A57434/1-231 97.6% 14.0% KEDVRILKVCFYSNSF------------------NPGKNFKL-VKCTVQTEIQEIITSILLSGR-IGPNIQLAECYGLRL 47 P90536/1-220 98.1% 14.7% NGDISTCKIRFIDQS--------------------TKLAKIN-TYTTIREITDTVCRQYGI-------SQQSIKMFGISA 48 O00522/1-225 98.1% 14.4% NKPYEKVRIYRMDGSY------------------RSVELKHG-NNTTVQQIMEGMRLSQETQQ--YFTIWICSENLSLQL 49 3875583/1-209 96.1% 14.3% SRRPKAL-IRLLDSQ--------------------QIEVVLH-SRLSVEDVLRLVAEKVDL-------SFPDSQYFCLGF 50 O02254/1-253 98.1% 11.3% SPKVVKFSIYFSRGERLSNE----------EENGIELNIESG-KTADTKKLLFHLAKECGI------DYSAFSEMFAIWM 51 Q18420/1-211 97.6% 13.9% SALDRCLRVGGRQEG--------------------PSRLEVT--SVLTRDVTRTKFPHSIS-------VKLPNSEYQIVE 52 JAK3_RAT/1-235 94.7% 11.8% SSEAGALHVLLPPRGPG---------------PPQRLSFSFG--DYLAEDLCVRAAKACGI-------LPVYHSLFALAT 53 TYK2_HUMAN/1-25 94.7% 10.2% MAAMGGLKVLLHWAGPG---------------GGEPWVTFSE-SSLTAEEVCIHIAHKVGI-------TPPCFNLFALFD 54 Q19928/1-288 93.2% 8.3% -EEKIFELLRRLPST--------------------SNFFVFD--YWTIEDNFETCCRNQLSQFTCYCNSIVSRIGDSLNF 55 JAK_DROME/1-227 95.6% 12.7% RSGTSSQSIHTNDGTIRV-------------FNFTTGEFERFHPNMLCEEICNTMCRQLGI-------APIAQLLYGIRE consensus/100% ........h.h...........................................h.....................th.. consensus/90% ......h.l.h.ttt.......................h.ht..t..st.hh..hhtthth..............aul.. consensus/80% p.t.h.hplhh.stp......................th.ht..p..spphh.thhpphtl..........ttthauL.h consensus/70% ptp.hhhplhhhssp.....................hphthp..ptpspclhpplspphsl.........hppphFuLhh cov pid 81 . 1 . . . . : . 160 1 MOEH_DROME/1-20 100.0% 100.0% TDSKGD-------------------------------------------------------------------------- 2 PTN4_HUMAN/1-19 95.1% 28.8% ADDSTDN------------------------------------------------------------------------- 3 41_HUMAN/1-196 94.7% 28.0% WDNATS-------------------------------------------------------------------------- 4 E1358784/1-205 97.1% 56.4% TIKDT--------------------------------------------------------------------------- 5 TALI_MOUSE/1-23 95.6% 17.8% ELMEEKKDEGTGTLRKDKTL------------------------------------------------------------ 6 Q20307/1-207 96.1% 43.3% TNKKNI-------------------------------------------------------------------------- 7 NBL4_MOUSE/1-20 95.6% 29.4% CDRSHQ-------------------------------------------------------------------------- 8 Q22860/1-259 95.6% 15.7% DDILMQNGGGGGGGGGQNGGSTWNLKEKESRSKS---------------------------------------------- 9 PTN3_HUMAN/1-19 95.1% 27.4% DDDSVDS------------------------------------------------------------------------- 10 Q24440/1-197 94.7% 28.8% ETPTDP-------------------------------------------------------------------------- 11 Q24564/1-209 97.6% 50.0% VDTRSN-------------------------------------------------------------------------- 12 Q14840/1-481 98.5% 9.6% KPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHD------------------------- 13 Q64512/1-214 96.6% 24.4% RKENEYFFVDPDLKLTKVAP------------------------------------------------------------ 14 Q18685/1-525 98.1% 8.9% YIPPEDLRRGTSDADNMNGP-LSMRPGEESVGPMTLRKAAPIFASQSNLDMRRRGQSPALSQSGHIFNAHEMGTLPRHGT 15 P91433/1-193 93.2% 28.5% TDPFNV-------------------------------------------------------------------------- 16 D1025178/1-195 94.2% 27.5% PDHKKI-------------------------------------------------------------------------- 17 Q24796/1-203 95.6% 45.8% IDKDGN-------------------------------------------------------------------------- 18 E1344361/1-202 93.2% 24.1% IAVDNSS------------------------------------------------------------------------- 19 PTNF_MOUSE/1-20 98.5% 28.0% YNKQNQ-------------------------------------------------------------------------- 20 PTNE_MOUSE/1-20 98.5% 26.1% LSKSQQ-------------------------------------------------------------------------- 21 3875752/1-201 95.6% 23.3% YDKDEGT------------------------------------------------------------------------- 22 P91092/1-200 95.6% 22.0% QDHHKH-------------------------------------------------------------------------- 23 O17905/1-219 95.6% 22.4% IDINGN-------------------------------------------------------------------------- 24 D1035494/1-195 94.2% 26.6% QNTQSY-------------------------------------------------------------------------- 25 Q13402/1-218 96.6% 17.3% KIADKVISVPENDFFFDFVRHL---------------------------------------------------------- 26 TALA_DICDI/1-19 94.2% 18.8% SA------------------------------------------------------------------------------ 27 O77433/1-227 99.5% 14.9% DDPIEK-------------------------------------------------------------------------- 28 EXPA_DROME/1-28 98.5% 14.3% LIDGEYMFADPESKLSKYGP------------------------------------------------------------ 29 WORM|CE18186|T0 96.6% 19.3% LRDGEHYFIEDHQRLE---------------------------------------------------------------- 30 P91443/1-220 97.1% 13.7% KIKDKVLAVPESEFFFDYVRSL---------------------------------------------------------- 31 O57612/1-253 95.1% 9.5% EKD----------------------------------------------------------------------------- 32 O93596/1-234 92.7% 12.9% ERD----------------------------------------------------------------------------- 33 O24147/1-225 98.1% 16.6% CRKVVTGSKSPDPGN----------------------------------------------------------------- 34 A39577/1-255 96.1% 11.0% ENT----------------------------------------------------------------------------- 35 G3790763/1-249 100.0% 16.1% EYSLGAR------------------------------------------------------------------------- 36 Q13402_1/1-216 95.6% 18.2% ALFDKVSSLGSGSDHVMDAI------------------------------------------------------------ 37 JAK2_RAT/1-238 94.2% 12.0% ETE----------------------------------------------------------------------------- 38 P91443_1/1-215 96.1% 17.9% ALFDKVSSLGSGTDHVMDAI------------------------------------------------------------ 39 O15032/1-223 97.1% 14.5% EQRTEGAGT----------------------------------------------------------------------- 40 D1035500/1-263 96.1% 12.9% YNGHVDKAIESRTVVADVL------------------------------------------------------------- 41 E1354398/1-223 95.6% 16.4% RQPTEGIGGDQPRHE----------------------------------------------------------------- 42 O42291/1-238 95.1% 10.5% EDL----------------------------------------------------------------------------- 43 Q91563/1-228 99.0% 13.9% SHLHSEE------------------------------------------------------------------------- 44 JAK1_CYPCA/1-25 95.6% 9.8% ESQDL--------------------------------------------------------------------------- 45 Q20456/1-219 93.7% 14.7% TVGKDKH------------------------------------------------------------------------- 46 A57434/1-231 97.6% 14.0% KHMKSDE------------------------------------------------------------------------- 47 P90536/1-220 98.1% 14.7% VNETAGISKV---------------------------------------------------------------------- 48 O00522/1-225 98.1% 14.4% KPYHKPLQHV---------------------------------------------------------------------- 49 3875583/1-209 96.1% 14.3% SDNLNN-------------------------------------------------------------------------- 50 O02254/1-253 98.1% 11.3% ISPLLEVQLKSYHRP----------------------------------------------------------------- 51 Q18420/1-211 97.6% 13.9% FDGKQKLCDAL--------------------------------------------------------------------- 52 JAK3_RAT/1-235 94.7% 11.8% EDL----------------------------------------------------------------------------- 53 TYK2_HUMAN/1-25 94.7% 10.2% AQA----------------------------------------------------------------------------- 54 Q19928/1-288 93.2% 8.3% ACVDNGHYRNVMFSI----------------------------------------------------------------- 55 JAK_DROME/1-227 95.6% 12.7% HST----------------------------------------------------------------------------- consensus/100% ................................................................................ consensus/90% ................................................................................ consensus/80% ................................................................................ consensus/70% tp..t........................................................................... cov pid 161 . . . 2 . . . . 240 1 MOEH_DROME/1-20 100.0% 100.0% -------------------------------------------------------------------STWIK--LYKKVM 2 PTN4_HUMAN/1-19 95.1% 28.8% -------------------------------------------------------------------PRWLD--PNKPIR 3 41_HUMAN/1-196 94.7% 28.0% -------------------------------------------------------------------KTWLD--SAKEIK 4 E1358784/1-205 97.1% 56.4% -------------------------------------------------------------------VAWLK--MDKKVL 5 TALI_MOUSE/1-23 95.6% 17.8% ------------------------------------------------LRDEKKMEKLKQKLHTDDELNWLD--HGRTLR 6 Q20307/1-207 96.1% 43.3% -------------------------------------------------------------------PCWLQ--NDKTIC 7 NBL4_MOUSE/1-20 95.6% 29.4% -------------------------------------------------------------------TYWLD--PAKTLA 8 Q22860/1-259 95.6% 15.7% -----------------------------------SDRGGGGIYGTMRKKNEQKLEELRKKLHTDEELPWLD--HTKTLR 9 PTN3_HUMAN/1-19 95.1% 27.4% -------------------------------------------------------------------PRWLE--ASKPIR 10 Q24440/1-197 94.7% 28.8% -------------------------------------------------------------------RTWLD--LEKPVS 11 Q24564/1-209 97.6% 50.0% -------------------------------------------------------------------VSWLK--MEKRVR 12 Q14840/1-481 98.5% 9.6% ---------------GSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKINQGWLD--SSRSLM 13 Q64512/1-214 96.6% 24.4% -------------------------------------------------------------------EGWKE--EPKRKG 14 Q18685/1-525 98.1% 8.9% LPRGVSPSPGAYNDTMRRTPIMPSISFSEGLENEQFDDALIHSPRLAPSRDTPVFRPQNYVEKAAINRGWLD--SSRSLM 15 P91433/1-193 93.2% 28.5% -------------------------------------------------------------------QHWLD--PTKKVA 16 D1025178/1-195 94.2% 27.5% -------------------------------------------------------------------TVWLD--LLKPIV 17 Q24796/1-203 95.6% 45.8% -------------------------------------------------------------------PTFLR--LDKKIS 18 E1344361/1-202 93.2% 24.1% ----------------------------------------------------------------AQQKKWLD--PSKNLR 19 PTNF_MOUSE/1-20 98.5% 28.0% -------------------------------------------------------------------RRWVD--LEKPLK 20 PTNE_MOUSE/1-20 98.5% 26.1% -------------------------------------------------------------------ARWVE--LEKPLK 21 3875752/1-201 95.6% 23.3% -------------------------------------------------------------------RHWLY--NDKNIA 22 P91092/1-200 95.6% 22.0% -------------------------------------------------------------------RYWLD--LTRSIN 23 O17905/1-219 95.6% 22.4% -------------------------------------------------------------------HCWLD--REKTIL 24 D1035494/1-195 94.2% 26.6% -------------------------------------------------------------------WIWLE--PMKPII 25 Q13402/1-218 96.6% 17.3% -------------------------------------------------------------------TDWIK--KARPIK 26 TALA_DICDI/1-19 94.2% 18.8% -------------------------------------------------------------------GAWLN--NTQILS 27 O77433/1-227 99.5% 14.9% ---------------------------------------------------DLEHYLEPLAKLCDVISKWET--ALREKG 28 EXPA_DROME/1-28 98.5% 14.3% -------------------------------------------------------------------KSWRS--SHTHGL 29 WORM|CE18186|T0 96.6% 19.3% -------------------------------------------------------------------KFAPS--GWKSVA 30 P91443/1-220 97.1% 13.7% -------------------------------------------------------------------SDWVH-TNHATQK 31 O57612/1-253 95.1% 9.5% -------------------------------------------------------------------NMWYP--PNYEFT 32 O93596/1-234 92.7% 12.9% -------------------------------------------------------------------RVWL---PPNHIF 33 O24147/1-225 98.1% 16.6% -----------------------------------------------------------------EEYICLD--ENKYIG 34 A39577/1-255 96.1% 11.0% -------------------------------------------------------------------KLWYA--PNRTIT 35 G3790763/1-249 100.0% 16.1% -------------------------------------------------------------------TSRIS--LLRPDC 36 Q13402_1/1-216 95.6% 18.2% -------------------------------------------------------------------SQCEQ--YAKEQG 37 JAK2_RAT/1-238 94.2% 12.0% -------------------------------------------------------------------RIWY---PPNHVF 38 P91443_1/1-215 96.1% 17.9% -------------------------------------------------------------------SQCEQ--YAKEQG 39 O15032/1-223 97.1% 14.5% -------------------------------------------------------------------KLLLL--HEQETL 40 D1035500/1-263 96.1% 12.9% -------------------------------------------------------------------AKFEK--LAATSE 41 E1354398/1-223 95.6% 16.4% -------------------------------------------------------------------YYFLD--PAAKIM 42 O42291/1-238 95.1% 10.5% -------------------------------------------------------------------SCWYPPNHLFTVE 43 Q91563/1-228 99.0% 13.9% -------------------------------------------------------------------VHWLH--PDIGVS 44 JAK1_CYPCA/1-25 95.6% 9.8% -------------------------------------------------------------------WYAPN--HAFKIT 45 Q20456/1-219 93.7% 14.7% -------------------------------------------------------------------LNYCK--NDNYLM 46 A57434/1-231 97.6% 14.0% -------------------------------------------------------------------IHWLH--PQMTVG 47 P90536/1-220 98.1% 14.7% -------------------------------------------------------------------VSETD--MIYDVL 48 O00522/1-225 98.1% 14.4% -------------------------------------------------------------------RDWPE--ILAELT 49 3875583/1-209 96.1% 14.3% -------------------------------------------------------------------FHWLD--GSVILY 50 O02254/1-253 98.1% 11.3% -------------------------------------------------------------------YECRQ--GWSTLL 51 Q18420/1-211 97.6% 13.9% -------------------------------------------------------------------STWET--RSRDAQ 52 JAK3_RAT/1-235 94.7% 11.8% -------------------------------------------------------------------SCWFPPSHIFSIE 53 TYK2_HUMAN/1-25 94.7% 10.2% -------------------------------------------------------------------QVWL---PPNHIL 54 Q19928/1-288 93.2% 8.3% -------------------------------------------------------------------NYLI----DQKLF 55 JAK_DROME/1-227 95.6% 12.7% -------------------------------------------------------------------SRRP-----SPLV consensus/100% ................................................................................ consensus/90% .....................................................................h........h. consensus/80% .....................................................................ahp....t.lh consensus/70% ....................................................................tWhp...tpplh cov pid 241 : . . . . 3 . . 320 1 MOEH_DROME/1-20 100.0% 100.0% NQDVK-------------KENPLQFRFRAKFYPEDV----------------------------AEELIQDITLR--LFY 2 PTN4_HUMAN/1-19 95.1% 28.8% KQLKR--------------GSPYSLNFRVKFFVSD-----------------------------PNKLQEEYTRY--QYF 3 41_HUMAN/1-196 94.7% 28.0% KQVRG---------------VPWNFTFNVKFYPPD-----------------------------PAQLTEDITRY--YLC 4 E1358784/1-205 97.1% 56.4% DHDVS-------------KEEPVTFHFLAKFYPENA----------------------------EEELVQEITQH--LFF 5 TALI_MOUSE/1-23 95.6% 17.8% EQGVE---------------EHETLLLRRKFFYSD-----------------------------QNVDSRDPVQLN-LLY 6 Q20307/1-207 96.1% 43.3% GQDIQK----------DTSDGTFNFLFLVKFYPEDV----------------------------EPEIILDATRH--LFF 7 NBL4_MOUSE/1-20 95.6% 29.4% EHKELI-----------NTGPPYTLYFGIKFYAED-----------------------------PCKLKEEITRY--QFF 8 Q22860/1-259 95.6% 15.7% EQGIT---------------EEETLILRRKYFFSD-----------------------------SNVDSRDPVQLN-LLY 9 PTN3_HUMAN/1-19 95.1% 27.4% KQLKG--------------GFPCTLHFRVRFFIPD-----------------------------PNTLQQEQTRH--LYF 10 Q24440/1-197 94.7% 28.8% KFFRT---------------DTWPLTFAVKFYPPE-----------------------------PSQLKEDITRY--HLC 11 Q24564/1-209 97.6% 50.0% DQRVEL----------HASNNVYVFSFYAKFFPENV----------------------------SEELIQEITQH--LFF 12 Q14840/1-481 98.5% 9.6% EQDVK---------------ENEALLLRFKYYSFF-----------------------------DLNPKYDAIRIN-QLY 13 Q64512/1-214 96.6% 24.4% KAAVD-----------------FTLFFRIKFFMDD-----------------------------VSLIQHDLTCH--QYY 14 Q18685/1-525 98.1% 8.9% EQGIF---------------EGDIILLRFKFMNFF-----------------------------DLNPKYDPVRIN-QLY 15 P91433/1-193 93.2% 28.5% KQVAI--------------GPPFTLRFRVKFFTSEP----------------------------SSNLKEELTRY--QFF 16 D1025178/1-195 94.2% 27.5% KQIRR--------------PKHVVVKFVVKFFPPD-----------------------------HTQLQEELTRY--LFA 17 Q24796/1-203 95.6% 45.8% SNDFA-------------PGSEYDFKFMVKFYPENV----------------------------EEELIQTCTIT--HFY 18 E1344361/1-202 93.2% 24.1% KQMIC---------------PPYHLFFRVKFYVRD-----------------------------PNRLRDEFTRF--QFY 19 PTNF_MOUSE/1-20 98.5% 28.0% KQLDK-------------HALEPTVYFGVLFYVPS-----------------------------VSQLQQEITRY--QYY 20 PTNE_MOUSE/1-20 98.5% 26.1% KHLDK-------------FANEPLLFFGVMFYVPN-----------------------------VSRLQQEATRY--QYY 21 3875752/1-201 95.6% 23.3% KQIKG---------------LPWEFSFEVKFYPTT-----------------------------PTTIVDDHARY--YVF 22 P91092/1-200 95.6% 22.0% HVVKN------------FKTESMTLHLRFRYYPSD-----------------------------PARLRDPNLRY--QLF 23 O17905/1-219 95.6% 22.4% RQITN-------------GSTDAKFYFVVKFYTPN-----------------------------PIDLEEEYTRY--LFT 24 D1035494/1-195 94.2% 26.6% RQIRR--------------PKNVVLRLAVKFFPPD-----------------------------PGQLQEEYTRY--LFA 25 Q13402/1-218 96.6% 17.3% DGIVP--------------SLTYQVFFMKKLWTTT-------------------------------VPGKDPMADSIFHY 26 TALA_DICDI/1-19 94.2% 18.8% EQGIS---------------ENDITVLMKKFFFND-----------------------------ANIDRNDPVQLH-LLF 27 O77433/1-227 99.5% 14.9% SGKFE-------------NSRVIQLSYKNRLYWKH-----------------------------TIKCETDKERL--LLC 28 EXPA_DROME/1-28 98.5% 14.3% DANGR---------------PLLELHFRVQFYIES-----------------------------PFMLKDETSRH--NYY 29 WORM|CE18186|T0 96.6% 19.3% RVGVK---------------VPYVLHLRFKFYPQI------------------------------LDFIKTDVTMN-ELY 30 P91443/1-220 97.1% 13.7% DATMI--------------PINYQVYFMRKLWYNF-------------------------------VAGADPQADIIFHY 31 O57612/1-253 95.1% 9.5% VTEEI----------------SLKLHYRMRFYFRNWHGNTEGESSVWRHCISKLRGSLSPQKIPVGTPLLDAASLE-YLF 32 O93596/1-234 92.7% 12.9% KIEPS---------------ANETLLFRVRFYFPGWYGSGCSS------------ARRYGLSRSSEAPVCDDITTA-YLC 33 O24147/1-225 98.1% 16.6% DLLEDFKALK---DRSKGEILHCKLSFKKKLFRES-----------------------------DEAVTEPMFVQ--LSY 34 A39577/1-255 96.1% 11.0% VDDKM----------------SLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLE-YLF 35 G3790763/1-249 100.0% 16.1% KIKSIVD---------LPNSEHLRCVFRLSFAPSDA---------------------------FVLLLSDPKALE--YYY 36 Q13402_1/1-216 95.6% 18.2% AQERN---------------APWRLFFRKEVFTPW------------------------------HSPSEDNVATN-LIY 37 JAK2_RAT/1-238 94.2% 12.0% HIDES---------------TRHNILYRIRFYFPHWYCSGSNR------------TYRYGVSRGAEAPLLDDFVMS-YLF 38 P91443_1/1-215 96.1% 17.9% RQERN---------------APWRLFFRKEIFSPW------------------------------HDPRDDPVSTN-LIY 39 O15032/1-223 97.1% 14.5% TQVTQR-----------PSSHKMRCLFRISFVPKDP----------------------------IDLLRRDPVAFE-YLY 40 D1035500/1-263 96.1% 12.9% VGDLP-----------------WKFYFKLYCFLDT-----------------------------DNVPKDSVEFA--FMF 41 E1354398/1-223 95.6% 16.4% KYAQKQPRFANWHSKSSENRPILVLYFRVRVYIDQ-----------------------------VGLLSCPKARE--HYY 42 O42291/1-238 95.1% 10.5% DARSQ------------------VVVYRIRFFFPNWCGQGQV--------------HRFQLPSDRPSPVLDYPVID-YLF 43 Q91563/1-228 99.0% 13.9% HIREKYE--------QSHPPEEWKYELRIRYLPKGF----------------------------VNQFTEDKPTLN-FFY 44 JAK1_CYPCA/1-25 95.6% 9.8% EETSI------------------KLHYRMRFYFTNWHAPVRTESPVWRHSLFKHKGVSVSPKGPEGTPLLDAASLE-YLF 45 Q20456/1-219 93.7% 14.7% DIITES----------EHKKLPFQFYLKRTVWVHP--------------------------------LRYDNAAYIDSMF 46 A57434/1-231 97.6% 14.0% EVQDKYE--------CLHVEAEWRYDLQIRYLPEDF----------------------------MESLKEDRTTLL-YFY 47 P90536/1-220 98.1% 14.7% ARWEQS-----------EEKGEFYFQVRRRFFLDDVNKI---------------------LDQEHLWTDDDICFE--LTY 48 O00522/1-225 98.1% 14.4% NLDPQ--------------RETPQLFLRRDVRLPLE----------------------------VEKQIEDPLAIL-ILF 49 3875583/1-209 96.1% 14.3% DLVAST----------SNPKGTLTLSHHVRFFVDT-----------------------------IYEVQCASTAK--LFF 50 O02254/1-253 98.1% 11.3% ERFAK-----------------ETDIQLFNQDEPILMLRRNA--------------SLTCDKEFELLQDHPKCAK--YLI 51 Q18420/1-211 97.6% 13.9% RGRVI-------------SDCAAALSLRMRHYWGH------------------------------LALTETPIERQ-FLV 52 JAK3_RAT/1-235 94.7% 11.8% DVDTQ------------------VLVYRLRFYFPGWFGLETCH-------------RFGLHK-DLTSAILDVHVLE-HLF 53 TYK2_HUMAN/1-25 94.7% 10.2% EIPRD---------------ASLMLYFRIRFYFRNWHGMNPREPAVYR--CGPPGTEASSDQTAQGMQLLDPASFE-YLF 54 Q19928/1-288 93.2% 8.3% DKVVK------------PKTGKNIVIYKVKLLTNL-------------------------------------NLSN-KIL 55 JAK_DROME/1-227 95.6% 12.7% RLDLTWC------LPGERLNCQLVYCFRMRFRVPEL----------------------------DSQLELIDGRSHKFLY consensus/100% ...............................................................................h consensus/90% t.......................h.hhhphh..............................................hh consensus/80% c...t...................hhhth+ha..t...................................p.hth...ha consensus/70% ct.hp.................hthhaph+aa..s...............................t..p-.sth..hha cov pid 321 . . : . . . . 4 400 1 MOEH_DROME/1-20 100.0% 100.0% LQVKNAILTDEIYCP-----------PETSVLLASYAVQARHGDHNKT-------------------------------- 2 PTN4_HUMAN/1-19 95.1% 28.8% LQIKQDILTGRLPCP-----------SNTAALLASFAVQSELGDYDQS-------------------------------- 3 41_HUMAN/1-196 94.7% 28.0% LQLRQDIVAGRLPCS-----------FATLALLGSYTIQSELGDYDPE-------------------------------- 4 E1358784/1-205 97.1% 56.4% LQVKKQILDEKIYCP-----------PEASVLLASYAVQAKYGDYDPS-------------------------------- 5 TALI_MOUSE/1-23 95.6% 17.8% VQARDDILNGSHPVS-----------FDKACEFAGFQCQIQFGPHNEQ-------------------------------- 6 Q20307/1-207 96.1% 43.3% LQIREAILSMNLYCS-----------PEASVLLASFAVQAMHGDCTEE-------------------------------- 7 NBL4_MOUSE/1-20 95.6% 29.4% LQVKQDALQGRLPCP-----------VNIAAQMGAYAIQAELGDHDPY-------------------------------- 8 Q22860/1-259 95.6% 15.7% VQCRDGILRGLHPVE-----------KETAFQLAALQSHIQYGDFPYD-------------------------------- 9 PTN3_HUMAN/1-19 95.1% 27.4% LQLKMDICEGRLTCP-----------LNSAVVLASYAVQSHFGDYNSS-------------------------------- 10 Q24440/1-197 94.7% 28.8% LQVRNDILEGRLPCT-----------FVTHALLGSYLVQSEMGDYDAEE------------------------------- 11 Q24564/1-209 97.6% 50.0% LQVKQSILSMDIYCR-----------PEASVLLASYAVHVQYGPYDYE-------------------------------- 12 Q14840/1-481 98.5% 9.6% EQAKWAILLEEIECT-----------EEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTST 13 Q64512/1-214 96.6% 24.4% LQLRKDLLDERVHCD-----------DEAALLLASLALQAEYGDYQPE-------------------------------- 14 Q18685/1-525 98.1% 8.9% EQAKWSILLDEFDHT-----------EEEATLFAALQLQATLQRDSPEPEENNKDDVDILLDELEQNLDAAALNRRSDLT 15 P91433/1-193 93.2% 28.5% LQIKQDISSGRLQCP-----------HQLAIELAAFALQSELGDYNPE-------------------------------- 16 D1025178/1-195 94.2% 27.5% LQVKQDLAQGRLTCN-----------DTSAALLISHIVQSEIGDFDEA-------------------------------- 17 Q24796/1-203 95.6% 45.8% LQVKSDIMSGKIYCP-----------TDTAVLLASYACVAKYGPYDPQ-------------------------------- 18 E1344361/1-202 93.2% 24.1% QQVRQNLEEGRLPCN-----------EGSLALLASYVVQAEVGDFEEKTH------------------------------ 19 PTNF_MOUSE/1-20 98.5% 28.0% LQLKKDILEGNLPCT-----------LEHAIQLAGLAVQADFGDFDQY-------------------------------- 20 PTNE_MOUSE/1-20 98.5% 26.1% LQVKKDVLEGRLRCS-----------LEQVIRLAGLAVQADFGDYNQF-------------------------------- 21 3875752/1-201 95.6% 23.3% LQLRRDLLTGRLPAT-----------ADTHSLLGSFVAQIEFGDAPAE-------------------------------- 22 P91092/1-200 95.6% 22.0% VQLQRDLLHGRLYCP-----------TSSAAELAALILQAQLGDYNEE-------------------------------- 23 O17905/1-219 95.6% 22.4% MQIKRDLALGELHCS-----------DNTASLLSAYLVQSECGDFSSE-------------------------------- 24 D1035494/1-195 94.2% 26.6% LQLKRDLLEERLTCA-----------DTTAALLTSHLLQSEIGDYDET-------------------------------- 25 Q13402/1-218 96.6% 17.3% YQELPKYLRGYHKCT-----------REEVLQLGALIYRVKFEEDKSY-------------------------------- 26 TALA_DICDI/1-19 94.2% 18.8% VQCRDGIIEGKYPTQ-----------REESLALSALQCQVQLGDYNPT-------------------------------- 27 O77433/1-227 99.5% 14.9% YQTNSQIVQGRFPLS-----------RELALELASLMSQIDMGDYSLE-------------------------------- 28 EXPA_DROME/1-28 98.5% 14.3% LQLRHNILQRDLPREQ---------ADEALVFLAGLALQADLGDAPPGTSNSKDDSGEETLASPSNGGRGLS-------- 29 WORM|CE18186|T0 96.6% 19.3% LQCRRDVLEERIQPK-----------RDAAFELAALALQAEFGNRPPP-------------------------------- 30 P91443/1-220 97.1% 13.7% HQESQKYLLGYHKTT-----------KNDVIELAALILRSMTKDGKNA-------------------------------- 31 O57612/1-253 95.1% 9.5% YQGQHSFHKGLVPVRKSHSDTEQHEIENECLGMAVLAITHTTNVGAPG-------------------------------- 32 O93596/1-234 92.7% 12.9% AQWRSDFLSGAVSVPVS------LEFQEECLGLAVLDIMRLAKEK----------------------------------- 33 O24147/1-225 98.1% 16.6% VQLQHDYIMGNYPVG-----------KDDAAQMSALQILVDIGYVDGPE------------------------------- 34 A39577/1-255 96.1% 11.0% AQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLP------------------------------ 35 G3790763/1-249 100.0% 16.1% QQCVNDVVRGRFAMEM---------RYEACIRLAALHVQQVAYDCNILKENN---------------------------- 36 Q13402_1/1-216 95.6% 18.2% QQVVRGVKFGEYRCE----------KEDDLAELASQQYFVDYGSEMILE------------------------------- 37 JAK2_RAT/1-238 94.2% 12.0% AQWRHDFVHGWIKVPVT------HETQEECLGMAVLDMMRIAKEKDQT-------------------------------- 38 P91443_1/1-215 96.1% 17.9% QQVIRGIKYGEYRCD----------KDEELAAICAQQYYIDEGTMDVN-------------------------------- 39 O15032/1-223 97.1% 14.5% VQSCNDVVQERFGPEL---------KYDIALRLAALQMYIATVTTKQTQK------------------------------ 40 D1035500/1-263 96.1% 12.9% EQAHEAVIHGHHPAP-----------EENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKT------- 41 E1354398/1-223 95.6% 16.4% LQLKDNFLDHWAGRNS--------VSEERCWYMAALALITDKGNDYLG-------------------------------- 42 O42291/1-238 95.1% 10.5% AQSRSDFIAGRMELALS------LAGQEECLSLAVLDMLRIAKEKWQSP------------------------------- 43 Q91563/1-228 99.0% 13.9% QQVKNDYMSEIADQV----------DQEIALKLGCLEIRRSYGEMRGNALEK---------------------------- 44 JAK1_CYPCA/1-25 95.6% 9.8% AQGQYDFLRGLAPVRAPQNEAEKHEIENECLGMAVLAITHHAKSNDLP-------------------------------- 45 Q20456/1-219 93.7% 14.7% DQVIDDYLRGSLISTNSLG-QLTAATTEEIIKLAAYLFLLL-PDNPKG-------------------------------- 46 A57434/1-231 97.6% 14.0% QQLRNDYMQRYASKV----------SEGMALQLGCLELRRFFKDMPHNALDK---------------------------- 47 P90536/1-220 98.1% 14.7% CQIRDEWMKGLYTNV----------NEKDSSIIAAILIQLLYPNQSKL-------------------------------- 48 O00522/1-225 98.1% 14.4% DEARYNLLKGFYTAP-----------DAKLITLASLLLQIVYGNYESK-------------------------------- 49 3875583/1-209 96.1% 14.3% FDIHNQLARHELLVT-----------SEDYFELVAILVSVFVPDCQEHTT------------------------------ 50 O02254/1-253 98.1% 11.3% YDASEMLLLGRLHLL----------SLENTIRVAAFLFCLQFGNFDET-------------------------------- 51 Q18420/1-211 97.6% 13.9% WRASEEIVNGRIPLS-----------NQLCESLAALYAQMVFGDANQS-------------------------------- 52 JAK3_RAT/1-235 94.7% 11.8% AQHRSDLVSGRLPVGLS------LKDQGEFLSLAVLDLAQMARKQAQRP------------------------------- 53 TYK2_HUMAN/1-25 94.7% 10.2% EQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIP-------------------------------- 54 Q19928/1-288 93.2% 8.3% FQFQDQVISGSLPCP-----------KEEAAYLASIQLSVEEQWPSNKRTQTIRRHLLKGQFGRIRDLAQKIMVTPWEVD 55 JAK_DROME/1-227 95.6% 12.7% RQMRYDMRTEQIPEIRYP------EHKDKSTGLAVMDMLIDDQEQSEDQQ------------------------------ consensus/100% .p....h....h....................h............................................... consensus/90% .Qhp.thh.t.h...............t..h.hush.h...h...................................... consensus/80% .Qhppshhpt.h.h.............pthh.luuh.hth.htpht.................................. consensus/70% hQh+psllpsph.ss...........pppsh.LAuhthphthsshs.t................................ cov pid 401 . . . . : . . . 480 1 MOEH_DROME/1-20 100.0% 100.0% ----------------------------------------------THTAGFLANDRLLPQRVIDQHKMS---------- 2 PTN4_HUMAN/1-19 95.1% 28.8% ----------------------------------------------ENLSGYLSDYSFIPNQ------------------ 3 41_HUMAN/1-196 94.7% 28.0% ----------------------------------------------LHGVDYVSDFKLAPNQ------------------ 4 E1358784/1-205 97.1% 56.4% ----------------------------------------------VHKRGFLAQEELLPKRVIN------------LYQ 5 TALI_MOUSE/1-23 95.6% 17.8% ----------------------------------------------KHKAGFLDLKDFLPKEYVK--------------- 6 Q20307/1-207 96.1% 43.3% -------------------------------------------------VGPIDLDKHLPKSVID------------QYD 7 NBL4_MOUSE/1-20 95.6% 29.4% ----------------------------------------------KHTAGYVSEYRFVPDQ------------------ 8 Q22860/1-259 95.6% 15.7% -----------------------------------------------KPKFHLDGRDVLPKEYAK--------------- 9 PTN3_HUMAN/1-19 95.1% 27.4% ----------------------------------------------IHHPGYLSDSHFIPDQ------------------ 10 Q24440/1-197 94.7% 28.8% ----------------------------------------------MPTRAYLKDFKIAPNQ------------------ 11 Q24564/1-209 97.6% 50.0% ----------------------------------------------TYKDGMLAGGELLPKGVTD------------QYQ 12 Q14840/1-481 98.5% 9.6% ILGDIT--XX--KQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKK 13 Q64512/1-214 96.6% 24.4% ----------------------------------------------VHGVSYFRLEHYLPARVMEKLDVS---------- 14 Q18685/1-525 98.1% 8.9% QVPELA--XX--MADSSYQQEVESIKNLLKMQSGNGNENGNSNTASRKAAAVKLPNDFNVDEYISSKYV--------RRA 15 P91433/1-193 93.2% 28.5% ----------------------------------------------LHTALFISEFRFHPEQ------------------ 16 D1025178/1-195 94.2% 27.5% -----------------------------------------------LDREHLAKNKYIPQQ------------------ 17 Q24796/1-203 95.6% 45.8% -----------------------------------------------SCPKSLPIDRLITGK--------------EQYD 18 E1344361/1-202 93.2% 24.1% -------------------------------------------GMSRTCLCYKIQFATLPDD------------------ 19 PTNF_MOUSE/1-20 98.5% 28.0% -----------------------------------------------ESQDFLQKFALLPVAWLQDEKV----------- 20 PTNE_MOUSE/1-20 98.5% 26.1% -----------------------------------------------DSQEFLREYVLFPMDLAMEEAA----------- 21 3875752/1-201 95.6% 23.3% --------------------------------------------MTDAYEQFIVASKLVPSAQAN--------------- 22 P91092/1-200 95.6% 22.0% ----------------------------------------------KHVGNYVSGYKLLLKQ------------------ 23 O17905/1-219 95.6% 22.4% ---------------------------------------------DYPDATYLSHTRFVPNQ------------------ 24 D1035494/1-195 94.2% 26.6% -----------------------------------------------LDREHLKVNEYLPGQ------------------ 25 Q13402/1-218 96.6% 17.3% -----------------------------------------------FPSIPKLLRELVPQDLIRQVS------------ 26 TALA_DICDI/1-19 94.2% 18.8% ----------------------------------------------KHEPGFLTLKDYLPLQWLKS-------------- 27 O77433/1-227 99.5% 14.9% -------------------------------------------KSRDVGVGLKGLDKFYPYRYRDALGAE---------- 28 EXPA_DROME/1-28 98.5% 14.3% ---------------------ATTTLPKISKRANERMLRLSTYVASTSKRETIPLPPSLPPNGADYYRIE----DYLPSG 29 WORM|CE18186|T0 96.6% 19.3% -----------------------------------------------VITDYFDIQHYLPKKYSSFEDQS---------- 30 P91443/1-220 97.1% 13.7% ----------------------------------------------PLAQIPQLLDEIIPKDSLKMYSAS---------- 31 O57612/1-253 95.1% 9.5% -------------------------------------------------SHDISYKRFIPETLNRSIKQR----SFLTPI 32 O93596/1-234 92.7% 12.9% ------------------------------------------GKSPVDIYNHSSYKSFLPKNMRE------------HIQ 33 O24147/1-225 98.1% 16.6% ----------------------------------------------SCTDWTSLLERFLPRQIAMTRA------------ 34 A39577/1-255 96.1% 11.0% -----------------------------------------------ELPKDISYKRYIPETLNKSIRQR---------- 35 G3790763/1-249 100.0% 16.1% ------------------------------------------KVSVHRVEKEYGLGTFLPAIVLENVKRRD---VRKHIR 36 Q13402_1/1-216 95.6% 18.2% -------------------------------------------------RLLNLVPTYIPDREITPLKT----------- 37 JAK2_RAT/1-238 94.2% 12.0% ---------------------------------------------PLAVYNSISYKTFLPKCVRA------------KIQ 38 P91443_1/1-215 96.1% 17.9% -------------------------------------------------KLENNLPSYLPDFEMSGKEMA---------- 39 O15032/1-223 97.1% 14.5% -------------------------------------------ISLKYIEKEWGLETFLPSAVLQS----------MKEK 40 D1035500/1-263 96.1% 12.9% ---------------------FTPCERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQMLDMWIKEEVSS---------- 41 E1354398/1-223 95.6% 16.4% ---------------------------------------------------YFRAEQYFPLWVINERG------------ 42 O42291/1-238 95.1% 10.5% ----------------------------------------------KEVFSCVSYKTCIPEQLRCQIQQ--------HSF 43 Q91563/1-228 99.0% 13.9% ------------------------------------------KSNYEVLEKDVGLKRFFPKSLLDSVKA----------- 44 JAK1_CYPCA/1-25 95.6% 9.8% ---------------------------------------------LSGVGAETSYKRFIPDSLNRTIK---------QRN 45 Q20456/1-219 93.7% 14.7% -------------------------------------------------LNAKTLPQIVPKSVIE------------PKH 46 A57434/1-231 97.6% 14.0% ------------------------------------------KSNFELLAKEVGLDLFFPKQMQE--------------N 47 P90536/1-220 98.1% 14.7% ------------------------------------------------VLTKEVVRQVLPDQILNSQNI----------- 48 O00522/1-225 98.1% 14.4% -------------------------------------------KHKQGFLNEENLKSIVPVTKLKSKA------------ 49 3875583/1-209 96.1% 14.3% -------------------------------------------AEAISRIMPMSHPPYILLKTDQS-------------- 50 O02254/1-253 98.1% 11.3% --------------------------------------------RHDVAFIRNHIDEILPERTCDSIVATT---IFGKAI 51 Q18420/1-211 97.6% 13.9% ---------------------------------------------LSDQQFEFISQRFYPSKMLDVACI----------- 52 JAK3_RAT/1-235 94.7% 11.8% ----------------------------------------------GELLKSVSYKACLPPSLRDLIQ--------GQSF 53 TYK2_HUMAN/1-25 94.7% 10.2% ---------------------------------------------LEEVAKKTSFKDCIPRSFRR------------HIR 54 Q19928/1-288 93.2% 8.3% QNLYCT---PPRFPNESANASRAQSVVEEIQHRSRTPTLLRCITNTDGLMSEEMQAQCLPVDLRGDRRT----------- 55 JAK_DROME/1-227 95.6% 12.7% ----------------------------------------------AMRSIEKLYKLYLPPSLWRAHSFF---------- consensus/100% ................................................................................ consensus/90% ........................................................thhP.t.................. consensus/80% ....................................................h...phlPtp.................. consensus/70% ................................................h.t.hshtphlPpph.p............... cov pid 481 . 5 . . . . ] 542 1 MOEH_DROME/1-20 100.0% 100.0% --KDEWEQSIMTWWQEH-----------------RSMLREDAMMEYLKIAQDLE-MYGVNYF 2 PTN4_HUMAN/1-19 95.1% 28.8% --PQDFEKEIAKLHQQH-----------------IGLSPAEAEFNYLNTARTLE-LYGVEFH 3 41_HUMAN/1-196 94.7% 28.0% --TKELEEKVMELHKSY-----------------RSMTPAQADLEFLENAKKLS-MYGVDLH 4 E1358784/1-205 97.1% 56.4% MTPEMWEERITAWYAEH-----------------RGRARDEAEMEYLKIAQDLE-MYGVNYF 5 TALI_MOUSE/1-23 95.6% 17.8% ---QKGERKIFQAHKNC-----------------GQMSEIEAKVRYVKLARSLK-TYGVSFF 6 Q20307/1-207 96.1% 43.3% MSADMWRDRIKRWWSRN-----------------AGQSREEAELEYLRVAQDLE-MYGILYY 7 NBL4_MOUSE/1-20 95.6% 29.4% --KEELEEAIERIHKTL-----------------MGQAPSEAELNYLRTAKSLE-MYGVDLH 8 Q22860/1-259 95.6% 15.7% --NKENEKKVVAMYKEL-----------------SGTSELDAKSKYVHLCRGLK-TYGVTFF 9 PTN3_HUMAN/1-19 95.1% 27.4% --NEDFLTKVESLHEQH-----------------SGLKQSEAESCYINIARTLD-FYGVELH 10 Q24440/1-197 94.7% 28.8% --TAELEDKVMDLHKTH-----------------KGQSPAEAELHYLENAKKLA-MYGVDLH 11 Q24564/1-209 97.6% 50.0% MTPEMWEERIKTWYMDH-----------------EPMTRDEVEMEYLKIAQDLD-MYGVNYF 12 Q14840/1-481 98.5% 9.6% YKNKQITARILEAHQNV-----------------AQMSLIEAKMRFIQAWQSLP-EFGITHF 13 Q64512/1-214 96.6% 24.4% ----YIKEELPKLHNTY-----------------AGASEKETELEFLKVCQRLT-EYGVHFH 14 Q18685/1-525 98.1% 8.9% RSKQQIQQRVSDAHGNV-----------------RQLTATEAKLQYIRAWQALP-EHGIHYF 15 P91433/1-193 93.2% 28.5% -------DEKMEVEILE-----------------SGQTPAQAELNYLNKARWIE-MYGVDMH 16 D1025178/1-195 94.2% 27.5% ---DALEDKIVEFHHNH-----------------IGQTPAESDFQLLEIARRLE-MYGIRLH 17 Q24796/1-203 95.6% 45.8% QTDEQWYERIIAYYKDH-----------------HDMSREDAMVQYLQIAQDLE-MYGVETF 18 E1344361/1-202 93.2% 24.1% -----FSDRVAELHQLH-----------------IGQTPDVAEQNFLDHARRLE-MYGMDVY 19 PTNF_MOUSE/1-20 98.5% 28.0% --LEEAAQKVALLHQKY-----------------RGLTAPEAELLYMQEVERMD-GYGEESY 20 PTNE_MOUSE/1-20 98.5% 26.1% --LEELTQKVAQEHKAH-----------------SGILPAEAELMYINEVERLD-GFGQEIF 21 3875752/1-201 95.6% 23.3% ---PETYKKIVDLHREM-----------------RGQTPSEAENQFLDHCKHLA-LYGIHLF 22 P91092/1-200 95.6% 22.0% --TPKLEERIANNHKEL-----------------KGKSSESAELEFLEKASQLD-TYAFDPY 23 O17905/1-219 95.6% 22.4% --TLEFQKKVMDNHRNF-----------------IGMTPGESDLAMLEVARRCD-FYGVKLH 24 D1035494/1-195 94.2% 26.6% ---QHCLEKILEFHQKH-----------------VGQTPAESDFQVLEIARKLE-MYGIRFH 25 Q13402/1-218 96.6% 17.3% --PDDWKRSIVAYFNKH-----------------AGKSKEEAKLAFLKLIFKWP-TFGSAFF 26 TALA_DICDI/1-19 94.2% 18.8% ---KGVEKDIFKEHKKL-----------------VSMTEVNAKYRYVQLCRSLK-TYGMTSF 27 O77433/1-227 99.5% 14.9% -QLKDVQELLVSKWMLL-----------------KGRSTLDCVRIYLTCCRKWP-YFGACLF 28 EXPA_DROME/1-28 98.5% 14.3% LHTPWARSAMRACHREH-----------------LGMATAEAELLYIQQACSLH-ETINAHT 29 WORM|CE18186|T0 96.6% 19.3% ----RLKNILAELHGHY-----------------AGTRISEAKHKYIQICQRHP-DFGAHVH 30 P91443/1-220 97.1% 13.7% ----EWRKTISNAYARI-----------------EHLKSDQAKIEFLNYICRWP-TFGSAFF 31 O57612/1-253 95.1% 9.5% RINNVFKKFLSEFHQRTV--------------RDSNITPYDLKIKYLATLEGLTSGLGSEVF 32 O93596/1-234 92.7% 12.9% NQHLVTRKRIRFRFRRFLQ-----------QFGSCKAAPRELKLKYVVSLETLQPAFYSEHF 33 O24147/1-225 98.1% 16.6% --KREWELDILSRYKLM-----------------ENLTKDDAKQQFLRILRTLP--YGNSVF 34 A39577/1-255 96.1% 11.0% --NLLTRMRINNVFKDFLKEFN------NKTICDSSVSTHDLKVKYLATLETLTKHYGAEIF 35 G3790763/1-249 100.0% 16.1% FYLKRDSSRLVDCFGKPTIGNGYPPELEACAAQFANEPSMMVRLRYIHIVSHLP-SFGGRSF 36 Q13402_1/1-216 95.6% 18.2% --LEKWAQLAIAAHKKG----------------IYAQRRTDAQ-KVKEDVVSYA-RFKWPLL 37 JAK2_RAT/1-238 94.2% 12.0% DYHILTRKRIRYRFRRFIQ-----------QFSQCKATARNLKLKYLINLETLQSAFYTEQF 38 P91443_1/1-215 96.1% 17.9% --LEKWTQTIMHQYRK------------------KFTGRLPSQIEVKENVVSVA-KTKWPLL 39 O15032/1-223 97.1% 14.5% NIKKALSHLVKANQNLVP--------------PGKKLSALQAKVHYLKFLSDLR-LYGGRVF 40 D1035500/1-263 96.1% 12.9% -----ARASIIDKWRKF-----------------QGMNQEQAMAKYMALIKEWP-GYGSTLF 41 E1354398/1-223 95.6% 16.4% --LEYIRNNLPAACEDI-----------------INEGRYKAMEKFMIEAGRSP--FALNCH 42 O42291/1-238 95.1% 10.5% LTRKRIRRRVAQSLRRM---------------GGCRVDGCCLKLKYLLDLERLR-CCWAEES 43 Q91563/1-228 99.0% 13.9% ---KTLRKLIQQTFRQF-----------------ANLNREESILKFFEILSPVY-RYDKECF 44 JAK1_CYPCA/1-25 95.6% 9.8% FSHVYVYNNVFKNFLNEFNS---------KTIQDSNITLYDLKVKYLSTLETLTQGLGRETI 45 Q20456/1-219 93.7% 14.7% RHQEEMVTRISRQLKMF----------------GGRMRPAEAKSHFLELLSTWP-TFGVLHY 46 A57434/1-231 97.6% 14.0% LKPKQFRKMIQQTFQQY-----------------ASLREEECVMKFFNTLAGFA-NIDQETY 47 P90536/1-220 98.1% 14.7% ---KVWISMIESQIFEL-----------------VSQTPEYLKLMFINLIGSKSPLFGCTLF 48 O00522/1-225 98.1% 14.4% ---PHWTNRILHEYKNLS------------TSEGVSKEMHHLQRMFLQNCWEIP-TYGAAFF 49 3875583/1-209 96.1% 14.3% ----EVERRVFEKFRYY-----------------RRLPVGTGMISFIKLAEKSE-SYGYRMY 50 O02254/1-253 98.1% 11.3% NKKTVQEERLLSEWKNIS---------------KIGDKSKKEHDLLMELTQNSS-CYGAAWF 51 Q18420/1-211 97.6% 13.9% ---KSLRLQINSNWSEL-----------------IGMSENECVRVILQVLGKWP-LFGSDLH 52 JAK3_RAT/1-235 94.7% 11.8% VTRRRIRRTVVQALAPC---------------SSLPSRPYALMAKYILDLERLHPAATTESF 53 TYK2_HUMAN/1-25 94.7% 10.2% QHSALTRLRLRNVFRRFLR-----------DFQPGRLSQQMVMVKYLATLERLAPRFGTERV 54 Q19928/1-288 93.2% 8.3% --IKLVKERKRKLFHSQ-----------------VYESEIGMKKLYIQTAKKLA-AFGCKVF 55 JAK_DROME/1-227 95.6% 12.7% -----VGSKIREVFRSL---------------KANSLSVERLKWHYVHQVSHLAPTYMTEQF consensus/100% .........h...................................hh..h......h..... consensus/90% .....h.t.l.t.ht....................t.t..t....hht.htth...ht.t.h consensus/80% .....hpppl.p.apph..................t.s..phphpalp.hpph..hauhpha consensus/70% .....hppplhphapph.................tshs.tpschpalphhpplt.haGhpha