Family alignment for the HEPN domain, displayed in

                     cov    pid  1 [        .         .         .         .         :         .         .         . 80 
 1 18160453/9-120 100.0% 100.0%    LRQAERDLIKAENDL-KTGDWDSAAFWSQQCAEKALKALL-LNAGKAYRG-HELLELA------RVIKEEIGV------D    
 2 Q97XB1/9-118    95.5%  33.0%    LRQAERNLKSAELNF-ENGIYEETCYEAQQVAEKSVKSLL-SYFHKEMRG-HSITFLL------QFSSISIP--------    
 3 SACS_MOUSE/370  99.1%  19.5%    LRQARANFSAARNDL-HKNANEWVCFKCYLSTKLALIAAD-YAVRGKSDKDVKPTALA------QKIEEYSQQL----EG    
 4 Q9YCI5/15-127   97.3%  33.6%    LRQAKHTLESIRVDY-EGGFYSWACFKANQAAEYSIKAVL-RAAGLESFG-HDLMALW------RRARSLCQPL------    
 5 AAK88591/225-3  98.2%  20.3%    LPDARDFADVAKYLV-AKGNLHLAAFNLHQAVETAYNCYL-LTLTNYSPASHNLKFLR-----GLSEGRDRRLIDIWPRD    
 6 Q92ZG2/148-268  98.2%  19.5%    LPHAKTFVEGTQFFV-SRGRRKEAAFLLHQSIEQTYAALL-LVLTSYSPASHNLRHLR-----SLAEERDQRLAEVWPRD    
 7 Q92VW9/195-315  98.2%  17.1%    FPSAPSFLDTAQYLV-RKNQLRHSAFELHQSIETAYSCLL-LTLTNYSPPSHSLKFLR-----GLAEDHDRRLVEVWPRD    
 8 AAK88587/185-3  98.2%  17.1%    FEAGTEFFVLSCHAR-NSGFTKRAAFLLHQAIEQAYSCVL-LTLTNYGPASHNIKFLR-----SLAEEQDLRLVDAFPRD    
 9 AAK90491/172-2  98.2%  17.1%    FGAGRNFAALSDAAL-QKGMISEAAFLLHQAIEQAYASVL-LTLTNYTPASHNLKVLR-----SFAEERDRRLIEAFPRD    
10 Q96XM5/11-118   92.9%  26.7%    FKSAKLTLESAKHDV-SGGFYNWACFKSQQAAEFAVKAYF-YGIGQPKTG-HTISSLL------NLLN----AP------    
11 18159896/9-122  97.3%  34.2%    FREGIRDCKTAELLF-NAGVYHSSAFYSHQAAEKVLKSLFYVFARREPPKRHNLLELY------RELKQHGA------EL    
12 Q97VT0/10-121   99.1%  51.3%    FRQALEDLATAKDTI-TTGHYYASAFWAEQAAEKALKALL-IENGKIERT-HDLNQLL------YVIKEEIGLP------    
13 18160957/6-115  96.4%  27.2%    YSRAGRFRALASEFL-RRGFYPEACFFAQQSAEFYLKGKL-IEVTGARLYTHSILQLL------TVLYQTLGR-----EL    
14 Q974A5/25-132   94.6%  32.5%    FEKSKEFLELAKKHL-DDGYFWFSCFASQQSVEFALKGLL-VKYKGMFPFTHDLGELA------EKVGKELGV-----NV    
15 Q972P8/5-114    94.6%  16.4%    FEKSDKDKEVAYLLL-DKGYYPEACFHAVMAVELRLKGVL-VQTTGGIIYTHSIKRLL------DEVAKIKNL-----QL    
16 Q9UZ01/10-121   93.8%  24.4%    FHRSKDYMSLANVAF-KEGKFDVAIFLAGQSLQLYLKATL-VKYADLRLRTHSIRELL------INIGKVFEMEEKVVEF    
17 Q97WD3/46-157   94.6%  19.5%    FQRANELLRASKFNF-NSGFYEIAAIAAVESLYLLLNATL-IRIGADIPWYLDFDGLF------RVISRYSND-DRIAEI    
18 O58422/9-118    93.8%  32.5%    WEQALEDLKTAEVLI-EVKRYYASVFFSQQAAEKALKALYIEVKREFPPKTHSLLRLS------NELG--IKD-------    
19 Q96ZS6/11-121   92.9%  19.3%    CRRALSYLKVAKDVF-HEGLYDVAATNCQISAELLIKSTY-LFLGFVYPETHNIRKLL------SELANLTKL-EEIGRL    
20 Q975T4/9-119    92.9%  19.3%    CKRSLEYLKASEEAF-INGLYNASGLMSQISAELAIKATI-AFLGYSFPETHEIRKLL------SVLSTLILK-DEISEF    
21 O58139/13-126   98.2%  34.5%    IVEAKRTLSSAYSDL-KEGYYEWASFKAQQAAELAVKAIL-RGLGFAPIG-HSITRLL------KDLSGSLNL-----DI    
22 Q97XN9/7-119    95.5%  37.3%    MIQAEEDLDVARVLL-EAGKYFAVTFYSQQAVEKALKSLL-IHLGKDPGKTHSLTELA-----SMIENEGLKIP------    
23 Q974G3/8-113    91.1%  36.2%    IKQAERDLEEARYAK-SGGYYELACFLSQQCAEKAVKGLL-QFQGIEKRG-HSISHLL------------TNPP------    
24 Q9WZ82/1-112    96.4%  27.6%    MDAAKDDLEHAKHDL-EHGFYNWACFSSQQAAEKAVKAVF-QRMGAQAWG-YSVPDFL------GELSSRFEIP------    
25 18159071/10-12  97.3%  35.0%    LEEAEDDFNAAADLA-RLGRYAKACFLSQQAAEKALKALL-IAKAGRYERTHSVYALL------LAAEKYGIPI------    
26 Q58700/15-135   99.1%  28.7%    IKRAEEDLEVAKVLL-KTNHYPDSVYHSQQCVEKAVKAVL-I-LNGIIFRRHVVSGVF-----RNVIYEMKIE-DSWKEK    
27 18161127/14-12  96.4%  32.8%    ITMAERTLSSARLDA-SHGEYNWACFKAHQAAEFALKALL-YGVGRPARG-HSLTHLL------GEVAKFATVS------    
28 Q972J0/11-121   93.8%  22.9%    LRRAEKFRKDAINAY-NEGYYDISCFYAEQAVQLRIKAYM-LRNLGFIPRIHGIRDLL------SIIYKYTRD-KKIMEF    
29 18160011/5-114  96.4%  29.8%    LEKASRYREYAKRNF-ESGAYDLACFLAQQSAEFLLKALL-IRETGARPLTHSLYEMA------RRLATLKNF-----EL    
30 18159235/9-122  98.2%  33.6%    IREAWADLCSAKVLY-GARRWNASAFYGHQAVEKALKSLYFVALRREPPNTHVLTELY------REIKRAGI------EF    
31 Q970M3/7-119    99.1%  41.2%    LEQAVEALDTANVLI-ITEKYYASAFYSQQAAEKALKSFV-LYLGKDPGKTHSLTELA------EILEKEGVQI------    
32 Q9YE10/14-125   98.2%  42.1%    LRAARRDLGRAEYSL-KVGDRAAATFWSQQAAEKALKGLL-LAFKGDYPKTHSIRRLL------EDLGLDLGLS------    
33 O28659/10-121   93.8%  21.8%    RERAFKFLKNAEQLI-ESGVYDIAAFNIQQFVELYLKYAL-FKKVGDYPKTPSIKRLL------REIGKASGKIDAVEEF    
34 18160446/7-116  96.4%  28.1%    IKKALRYRDYAREDL-INNRYDSAAFFAQQSVEFLLKGVL-IKLTGSRPLTHSLSELL------ALLAKVLGVS-----V    
35 O29662/11-116   92.9%  21.9%    RRRAMGFMDAAKERL-KVGDYDLTCFMAEQAVQLYLKSVI-LELSGEVPRTHSIRQLL------SILSKLLD------EQ    
36 18159706/8-116  93.8%  29.3%    ILGARLFLEVAREDL-RAGRYDLAAFHSEQAAQLALKYLL-ASTIGHYPHTHSLEVLF------KLAKAVRED---VWRL    
37 18159165/7-115  95.5%  20.2%    LDRGIAFMKMAYIAL-SSGVYNLTCFNAHQAIEMFLKGLI-VDATGSRPFTCSLTELL------EFLKRLGREV------    
38 Q96ZT1/28-141   94.6%  20.8%    MIKAQRYMELAKLAL-EKGFYSEVCFLSSLAAELYIKGVS-LAITGGFPTVHDLREIL-----NYIRINRKSESTIIDEF    
39 Q974J5/6-116    93.8%  16.1%    KENAIDFFNNAKDNL-SKGKYNLAMFSLEQALQLSLKYTL-YQLTGTFEKTHDVKRLM------KQVIEITKN-KELERI    
40 Q97YR7/7-110    91.1%  20.2%    LNNAKNFLHDARRDF-EEGIWNLSVFHSEQALQLCVKYKL-YIHLGDYPKTHDLKVLI------NSLGRFEKVE------    
41 Q973V6/5-115    93.8%  19.5%    KRNAIDFLNYAKLLL-RDGKYNLALFSLEQALQLWLKYYI-STLTGSFPKACDVVNLL------RRIIELTKN-EKLKEI    
42 Q96X92/5-108    92.0%  22.1%    LENAKNFFHDANRDF-EEGIWNLSVFRSEQALQLCVKYKL-YTYLGDYTKTHNLKELL------EALKRFENV------N    
43 Q973U8/10-120   93.8%  21.2%    LRRAKDYLRASELLF-QQGFYDASALNSEVSAQLSLKGLL-YKLGVEPSRTHGIRELL------SLVYTRLGD-ERIRDF    
44 Q973V4/10-134   97.3%  18.0%    KRRALRFLEEAKRDL-SEGYYDIGAFHVEQALQLYIKAVI-FELFGKDYEGHGIRELIGYLSKLLKENGYDELSKKIDEL    
45 O28687/5-108    92.0%  23.0%    KNKALRFYSKALESF-DKGEYDFTMFFVEQTVQLAIKYLI-ARRFGEIPKTHNLRILF------EIAEQEEFY-------    
46 Q973K3/6-116    93.8%  17.8%    KRNALDFFAGAEYDI-RNGKHNSAMSHVEQSLQLALKYVL-FQLKGSFEKTHDIISLL------DEVIDLTRN-EKLKKI    
47 P95880/15-122   91.1%  17.8%    LTTAKDYLKASELSF-EHNLYEASALNSEISAQLSLI----FKLGIEPPRTHGIRELL------SLIYAKLGD-KRISDF    
48 Q974A1/10-116   90.2%  23.7%    KERSKYFYKESMNDS-KNKRYDIALFHLEQALQLGLKAYL-LKNKGDFPRTHSLRDLIEL-ADNECLKKVIQR-------    
49 Q9V096/11-112   89.3%  32.5%    IKQAERNLRSALRDL-EGGDYEWASFKAQQAAELAVKALL-RGMGSAPIG-HSITRLL-----RNLVGEGIDVP------    
50 Q97X68/10-91    72.3%  18.6%    KRRALRFLDEAKRDL-NEGYYDIGSFHVEQALQLYIKAVI-FELFGKEYEGHGIRELL------GYLSKLLK--------    
51 Q97YY9/14-128   98.2%  25.6%    LNIAKKDNIRAKRAL-ELKDYPECLFYSQQSVEKSVKAML-EVKLIYKKE-HDIIADA-----SNNLQDLGNEL------    
52 Q97V55/15-132   99.1%  17.6%    ITQAEERLDLAKTEY-ERKKYNIVVRLCQEAVELSLKACL-RLVNIEPPKFHDVGPIL------KN-NTDKFP-QWFKEK    
53 Q974F9/5-113    92.9%  13.7%    RNKALEYLNASKLNF-EHGFYDIATVLAEEALYLYLVTCL-INHEVAIPWYLDFDGLL------RILEKHDNKI----SE    
54 O28564/56-138   74.1%  14.3%    VKMALQDFESVKILY-QSKIYSLAVYHLQQAVEKYVKAYV-LAFFGLSKK---------------EMKGYVG--------    
55 Q97Y72/11-129   96.4%  24.4%    LREAKIRIKYAELSLNEDKDYAFCVRASQEIVELSIKAIL-RLLGIEYGKIHDPGKIL--------VENMDRLPSWLKKE    
   consensus/100%                  h..u..............t....s.......h...h............................................    
   consensus/90%                   h.tu.t.ht.u...h.ptt.h..shh..p.shph.lp.hh...hh......hsl..lh..........t...........    
   consensus/80%                   hppA.p.hp.Ap..h.ptshat.usahspQuhphhlKshl.h.htt...t.HslhtLh........htp.ht........    
   consensus/70%                   hppAhc.hp.Ach.h.ppGhYphusFhspQusphtlKuhl.hthttt..t.HslptLh......t.ltp.ht........    

                     cov    pid 81          .         1         .         .         ] 130
 1 18160453/9-120 100.0% 100.0%    VSPIEEDLRELTIHYVISRYPNA---ANAVPYELYDEKKARELVERARRV    
 2 Q97XB1/9-118    95.5%  33.0%    -DWILKCAQELDKNYIPSRYPDVYDQGA--PLDYYSKDDATSCLECARKI    
 3 SACS_MOUSE/370  99.1%  19.5%    LTNDVHTLEAYGVDSLKTRYPDLLPFPQ-IPNDRFTSEVAMRVMECTACI    
 4 Q9YCI5/15-127   97.3%  33.6%    -QEMEECIAVLNKLYLPPRYPDAWPGGA-APFENYTRRDAEEALECASRV    
 5 AAK88591/225-3  98.2%  20.3%    RQRFTTWYNILNEAYVKARYSKRFEVSE-EALTWLQERTA-ELHKLVETL    
 6 Q92ZG2/148-268  98.2%  19.5%    QHQYVAWFNILNEAYVKSRYSKHYEISE-DALAWL-LERAHQLIADVEAI    
 7 Q92VW9/195-315  98.2%  17.1%    QHRFTAWYNILNEAYVKARYSKHFEITD-EALSWL-LERTEHLLRLVEMI    
 8 AAK88587/185-3  98.2%  17.1%    HHRQRAWFNTINEAYVKARYSKHFEISE-EALGWLGERTA-HLLELVKVV    
 9 AAK90491/172-2  98.2%  17.1%    HHRERAWFNTINEAYVKARYSSQYKISQ-EALDWI-GERATLLLSLVGEV    
10 Q96XM5/11-118   92.9%  26.7%    -QDLIDKAKYLDKLYVPTRYPDVWEEET--PAYYYTKKEAEEAIKYAEEI    
11 18159896/9-122  97.3%  34.2%    SPQLVDGLAVLTKYYATSRYPDA-AGGP--PSELFTKREAEYALEIAKEL    
12 Q97VT0/10-121   99.1%  51.3%    VEEIRSEVNKLTLHYTISRYPDA---ANTIPYSLYTKEDAEELVKKAEKV    
13 18160957/6-115  96.4%  27.2%    SEELVRCAKYLTEQYIGSRYPDA-------RMLEYDKDDAEQCIKCMEMI    
14 Q974A5/25-132   94.6%  32.5%    PDDIIRYCDLLTPHYVMSRY---------SQFTEYNRRKAEECLNSAITV    
15 Q972P8/5-114    94.6%  16.4%    NDKILDCANYLSLMYLGSRY----PEEEIIDMDRS---EGEKCVRCMETI    
16 Q9UZ01/10-121   93.8%  24.4%    IRSNRLLLRELEDAYIDARY------EPR----KYSREDAEELIEFANKV    
17 Q97WD3/46-157   94.6%  19.5%    RIKERDIISLLD--DIKIRLGYS------IPLELN-EKDTEKLIKFAERI    
18 O58422/9-118    93.8%  32.5%    -EEIIDAVLDLNPEYIVTRYPDAANEV---PAKIYNERIAVEHLEKAKKV    
19 Q96ZS6/11-121   92.9%  19.3%    VKEKRKELNLVE----LSRFEGQY-----SPIDVD-SDLASDCLDTVENI    
20 Q975T4/9-119    92.9%  19.3%    IKAKRGELILLEDARQRGQYFSYG----------LGKDDAEICLNTAREV    
21 O58139/13-126   98.2%  34.5%    PREILYFAMELDRNYIAPRYPDAYPEGS--PFEYYSEDIAKELVKYAEKI    
22 Q97XN9/7-119    95.5%  37.3%    -QNIMEDLMVISPHFIISRYPDAANGVP---ARQYTKNMAEDLYRRAKEV    
23 Q974G3/8-113    91.1%  36.2%    -ADILQCATFLDKQYTPSRYPDVYYEGA--PYEYYTERDADECINCAIRI    
24 Q9WZ82/1-112    96.4%  27.6%    -EELMDHALELDKACIPTRYPDALPSGS--PRNRYSRIEAERLVNYAEKI    
25 18159071/10-12  97.3%  35.0%    PPELKEAGEELDRHYVLSRYPNAWPWGP--PHVHYRQKDAESCLKNAKSV    
26 Q58700/15-135   99.1%  28.7%    LLNLIPKIESLEEHWVMPRYPEPYFGELWNPLEEYTKEDAEECLKDAENV    
27 18161127/14-12  96.4%  32.8%    -EEVAELCRLLDKFYVPTRCVDAWSEGI--PYEYFSKSDAETAIKAAEGV    
28 Q972J0/11-121   93.8%  22.9%    ISENRDLLKELEEGYTETRYGSI----------DYTEEDAKECLNIMEKL    
29 18160011/5-114  96.4%  29.8%    GDEVAKCAKALEHHYVQSRDPDA-------RVGEYERWEAESCIECMEAL    
30 18159235/9-122  98.2%  33.6%    SPGLEERIAELNKFYSVSRYPDA--AAGQ-PYEVVTKGDADRSLKTAEEV    
31 Q970M3/7-119    99.1%  41.2%    PVKIKENLMVLSPHFIISRYPDA---ANGVPYKQYNKSIAEDLYNRVKEV    
32 Q9YE10/14-125   98.2%  42.1%    -EGELEDAFELTQYYYLSRYPDV---VEELPDEVIGRRSAERAVNAARRI    
33 O28659/10-121   93.8%  21.8%    MRENIDRISNVENAYITSRY------IPS----EFERIEVENMLKLARKI    
34 18160446/7-116  96.4%  28.1%    PEEAMRCAEALESHYIQARYPDA-------RLNEYRKWEGEEAVKCMEAL    
35 O29662/11-116   92.9%  21.9%    FDFDRKQLVFLEDAYIKARY----------LGAGYEREDAEEAIKIAEEV    
36 18159706/8-116  93.8%  29.3%    YEENRMAFEVMEDAYLGGRY----------LPRRYAKEVAEHLVELAGRV    
37 18159165/7-115  95.5%  20.2%    PEGAFREAEWMEPHYILARYPAR-------GVKPYTETTAKRCIAVMELI    
38 Q96ZT1/28-141   94.6%  20.8%    IRENREELRLLSNEYLVSRY---------NLGYTYVKEDAEDCLNILLKV    
39 Q974J5/6-116    93.8%  16.1%    MNEQNVLLDLIEQSYITARY----------LPYKYEENTVEKALKVVEEI    
40 Q97YR7/7-110    91.1%  20.2%    IDELMLDFLVQS--YISSRY----------LPYTFSKESAEKALNFVENM    
41 Q973V6/5-115    93.8%  19.5%    LDSEISTLDLLKQAYIASRY----------LPTNYDKEAVEKALNIVEAI    
42 Q96X92/5-108    92.0%  22.1%    VDSLM--VDFLTQSYMSKRY----------LPYVFSKETAEKVLKFVENL    
43 Q973U8/10-120   93.8%  21.2%    IRDNREKLIILENIRGKSQY----------GLPPVSKDEAEIALFITKEI    
44 Q973V4/10-134   97.3%  18.0%    IREYRRQLVDIEDAYIDSRY--EIIEYESDDLKPL-IEVSESIIKILEEV    
45 O28687/5-108    92.0%  23.0%    -RNNLDVLREIELAYTASRY----------FDVEYSKEIAEKSLSVAKKV    
46 Q973K3/6-116    93.8%  17.8%    RNEEASTLEVIRESYIKSRY----------FHFYVDRLVVERAFNTTKVI    
47 P95880/15-122   91.1%  17.8%    TKENREKLIILENVRGKSQY----------GLPPVSRDEAEIALSTAQEI    
48 Q974A1/10-116   90.2%  23.7%    -KWYI--VSLLTDAYVGSRY----------LLRNYTEKEYKASKKFVEEV    
49 Q9V096/11-112   89.3%  32.5%    -KKLFYIAMKLDRNYMASRYPHV-----------YPEGS--PFEYYSEDS    
50 Q97X68/10-91    72.3%  18.6%    ----------------ENEY----------------EELAKKVNERVSGM    
51 Q97YY9/14-128   98.2%  25.6%    -DVVLNALDYLSGAWNISRYPFFNGNNITTPEEFVTEEMCKEGIKYSDEV    
52 Q97V55/15-132   99.1%  17.6%    IDIFASYSRSLRKERELSMYGDE--ETNTPPELLYSAYDGQQSIKIAEEI    
53 Q974F9/5-113    92.9%  13.7%    FRKNRKIIKVLDQIRIMFRY----SSLIS-----ISRDDAKEIILFVENI    
54 O28564/56-138   74.1%  14.3%    HDSPKAFIRLLD------RY----------------KRSLELFLKSIQKI    
55 Q97Y72/11-129   96.4%  24.4%    AENIAYISRWLRAEREPSMYGDEVEGIP--PTELYTESYCRKALESAKYV    
   consensus/100%                  ..................................................    
   consensus/90%                   ....h..h..lp..h..scY..............h.t..sp.hhp.ht.l    
   consensus/80%                   .pp.ht.h..lp..hh.sRY..............htcp.ucphlphsctl    
   consensus/70%                   .pp.hthhthLpttYhhuRY..............hsccpAcphlphscpl