cov pid 1 [ . . . . : . . . 80 1 PI3K_ARATH 100.0% 100.0% FRIEKLD-GNLPVK-----KSSDAGVVSIAEEKKP-------ELYIECALYID-------GAPFGLPMRTRL-------K 2 VP34_SCHPO 94.2% 6.3% MDRLVFSYCPSSKV------TARFLVKFCFIEYQDSQE----PCICTIQLFSGNESGSLMQKCFVSKIPNKS------LL 3 HSU57843_1 94.2% 9.1% KKPSSVSLWSLEQP------FRIELIQGSKVNADERM-----KLVVQAGLFHG-------NEMLCKTVSSSE------VS 4 P11A_HUMAN 96.2% 14.8% TSTKSLWVINRALR------IKILCATYVNLNIRDID-----KIYVRTGIYHG-------GEPLCDNVNTQR-------V 5 DMPI3K59F_1 97.1% 16.7% IKVGTLEGKKRQPD-------YEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQ-------GRPYCLPVTSSY-------K 6 P11B_HUMAN 94.2% 14.7% RIISHVWENNNPF--------QIVLVKGNKLNTEETV-----KVHVRAGLFHG-------TELLCKTIVSSE-------V 7 mm52193_1 95.2% 14.8% RNIKEAWTATEQLQ------FTVYAAHGISSNWVSNYE----KYYLICSLSHN-------GKDLFKPIQSKKVGTY---K 8 P11G_HUMAN 94.2% 11.8% VFTVSLWDCDRKFR------VKIRGIDIPVLPRNTDL-----TVFVEANIQHG--------QQVLCQRRTSP-------- 9 DMPHOS3KI_ 96.2% 11.7% KSISSLWDMGNYFQ------LTLHSISNVNFDKTRAL-----KVGVHVCLYHG-------DKKLCAQRSTDS-------P 10 vp34_yeast 98.1% 17.7% VKIKSLE-GHKPLLK----PSQKILNPELMLIGSNVFPSS--DLIVSLQVFDKE-----RNRNLTLPIYTPY-------I 11 CAVPS34_1 99.0% 14.7% VKVCYLE-CTRNNVSLVP-LSTKFEDPTVFKKLSQIYKNS--DLFVEIRVYDG-----KNNNLISTPVRTSY-------K 12 HSC2PI3K_1 95.2% 12.3% DLVQEACHFARSLAF------TVYATHRIPIIWATSYE----DFYLSCSLSHG-------GKDMCSPLQTRR-------A 13 AGE1_CAEEL 96.2% 9.9% LKQVSLWDLDANLMI------RPVNISGFDFPADV-------DMYVRIEFSVY------VGTLTLASKSTTK------VN 14 CEUB0025_3 99.0% 16.1% VYSCDLQTNVQVKVA-----EFEGIFRDVLNPVRRLN-----QLFAEITVYCN-------NQQIGYPVCTSFHTPPDSSQ 15 dmu52192_1 95.2% 7.8% TTPIPISCVSKPIV------VCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSK-------PNVLTCSNDTS--------G 16 HSPITR1_1 97.1% 31.0% LKIGSLE-GKREQK------SYNAVLEDPMLKFSGLYQETCSDLYVTCQVFAE-------GKPSALPVRTSY-------K 17 P3K1_DICDI 96.2% 11.7% ITHISIREIKKPFR------VKVMGSTRIPLSCIKDIDSS--SVIVSISLYHGIEC---FSKAFTQPIIPPP-------F 18 P3K2_DICDI 96.2% 14.9% VNIAGLRNLNFNNN-------EDARNKFADGKNNQP------NVFVMAELYYG-------GELLTNPVFTPIAQ-----L 19 P3K3_DICDI 95.2% 14.5% TVTENLQVRLLHA-----HEIFASKASEIIGTDSPSI-----QLFIEAAVYFG-------GELLATQSSKL--------V 20 CEF39B1_1 95.2% 10.3% PKVEVLSKMDFLQ-------IMLNSVHSIPEHWQSQYS----EFYMSLDLYHG----TQVLDGFSNKVPKTIKN-----D 21 P3K4_DICDI 100.0% 22.8% IKLCTLE-GKRNKENA--PETVDKWIDDPYLKYSSLYRDTTIDLYITCTLYSD-------GKQLSTSEHTSY-------N consensus/100% .....h.....................................h.h.hth...........t.................. consensus/90% h....h..h.......................ht........phhhthtl..t........p.h.....s.......... consensus/80% h.h.tl..ht...........h.hhhpt....hpt.......phhlphtlhtt.......sp.hs..h.op......... consensus/70% hphtslp.hsp.h........t.hhhpt..hphpp.......plhlphplaps.......sc.hstshpos......... cov pid 81 . 1 . . . . ] 144 1 PI3K_ARATH 100.0% 100.0% TTGPP-----YCWNELITL-SSKYRDLTAHSQLAITVWDVSC-GKTEGLIG------GATVLLF 2 VP34_SCHPO 94.2% 6.3% PTELSK-ISTHEWLDF-GVTVSELSLNAKFVVSAWKPS--FNDEEVYEF---VGCTTYRLFDEN 3 HSU57843_1 94.2% 9.1% VCSEP------VWKQRLEF-DINICDLPRMARLCFALYAVIEKAKKA---------RSTKKKSK 4 P11A_HUMAN 96.2% 14.8% PCSNP------RWNEWLNY-DIYIPDLPRAARLCLSICSVK--GRKGAKE------EHCPLAWG 5 DMPI3K59F_1 97.1% 16.7% AFGKR-----WSWNEWVTL-PLQFSDLPRSAMLVLTILDCS--GAGQTTVIG----GTSISMFG 6 P11B_HUMAN 94.2% 14.7% SGKND-----HIWNEPLEF-DINICDLPRMARLCFAVYAVLDKVKTKK--------STKTINPS 7 mm52193_1 95.2% 14.8% NFFYLI-----KWDELIIF-PIQISQLPLESVLHLTLFGVLNQSSGSS--------PDSNKQRK 8 P11G_HUMAN 94.2% 11.8% KPFTEE----VLWNVWLEF-SIKIKDLPKGALLNLQIYCGKAPALSSK--------ASAESPSS 9 DMPHOS3KI_ 96.2% 11.7% NGNFDT----FLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKK--------SSNNKDIA 10 vp34_yeast 98.1% 17.7% PFRNS-----RTWDYWLTL-PIRIKQLTFSSHLRIILWEYN--GSKQIPF------FNLETSIF 11 CAVPS34_1 99.0% 14.7% AFNNKG----RTWNQQLKL-NIDYNQISIDAYLKFSICEIID-TKPSVFGV-------SYLSLF 12 HSC2PI3K_1 95.2% 12.3% HFSKYLFHL-IVWDQQICF-PVQVNRLPRETLLCATLYALPI--PPPGS-------SSEANKQR 13 AGE1_CAEEL 96.2% 9.9% AQF-------AKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKV-KLKSEEFE----VGWVNMSLT 14 CEUB0025_3 99.0% 16.1% LARQKLI---QKWNEWLTL-PIRYSDLSRDAFLHITIWEHEDDEIVNNSTFSRRLVAQSKLSMF 15 dmu52192_1 95.2% 7.8% GLFPR-----LNFSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEP--------NADQNGER 16 HSPITR1_1 97.1% 31.0% AFSTR-----WNWNEWLKL-PVKYPDLPRNAQVALTIWDVYG-PGKAVP------VGGTTVSLF 17 P3K1_DICDI 96.2% 11.7% AFLAET--LSVDWCEWLVFTNIDYSNLPVDARLSISVYSANETVDDVE--------EIKNLDEA 18 P3K2_DICDI 96.2% 14.9% ASYGDGSVEFPNWEKGIAF-TIPIRYLPRAARASFTVYVTT--ISEALES------QMDEVVSK 19 P3K3_DICDI 95.2% 14.5% SFQDT-----VVWNEWVNI-PLAVSNIPNGARMCLGLNARYRGDIFNI--------GWVGHRLF 20 CEF39B1_1 95.2% 10.3% HFFPR-----IPLDLYAKFKRLNLCQYPRETRIVVSISGTVRNSAQAA--------NEYNPDIV 21 P3K4_DICDI 100.0% 22.8% PFSVS-----NKWDETIIF-PLKHQDLPFDTMIVITIWDIYS-PMKKVPIG------GTSFNIF consensus/100% ............h..........h...s..s...h............................. consensus/90% ............ap..h.h.sh.hpphsh.shh.h.l..h........................ consensus/80% sh..........Wsphl.h.slthpplshtshlshslhth......t...........tt.t.h consensus/70% sh..p.....h.Wsphlth.slphppLPttuhLshslhsh.t.sttt.........ttsphs.h