cov pid 1 [ . . . . : . . . 80 1 PI3K_ARATH 100.0% 100.0% -DRDLKP--SNIERKSIQRVLKYPPTRTLSGDERQLLWKFR-FSLMSEKRALT----------KFLR--CVEWSDVQEAK 2 CRU97662_1 99.5% 49.2% LDRDLKP--NSEERRRLQAILKLPPNKPLHAEERALLWRFR-ASLTQDTRALT----------KFLQ--CVDWSDATEAK 3 VP34_SCHPO 99.5% 44.3% -DKDLKP--NSKIRKELESILSYPPSEELSLEEKDLIWKFR-FYLTRNKKAMT----------KFLK--SVVWTDSSEVN 4 CEU56101_1 98.9% 20.8% --YESCIR-DPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLI-----------VLSELAFVWTDRENFS 5 HSU57843_1 99.5% 27.1% HSECVHV--TEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALA----------RLLL--VTKWNKHEDVA 6 P11A_HUMAN 99.5% 27.1% -ARDNEL--RENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCV-TIPEILP----------KLLL--SVKWNSRDEVA 7 DMPI3K59F_1 99.5% 33.2% SDRDANP-TASIRDQLHTIVYRYPPTYVLSSEEQDLLWKFRFYLS-SHKKALT----------KFLK--CINWKLEDEVT 8 P11B_HUMAN 100.0% 28.3% -NVSSRG--GKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLP----------KLLL--SIKWNKLEDVA 9 mm52193_1 98.4% 27.3% ---DKLETLESDIKGKLLDIIHRDSSFGLSKEDKVFLWENR-YYCLKHPNCLP----------KILA-SAPNWKWAN-LA 10 PI4K_HUMAN 95.7% 16.6% ---NVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVR-LDPGAVSDVPEAI-----------KFL----VTWHTIDADA 11 P11G_HUMAN 98.4% 29.5% ---RVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESL-KHPKAYP----------KLFS--SVKWGQQEIVA 12 DMPHOS3KI_ 99.5% 25.0% -AGPEKP--IKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELS-----------ILLH-CVYWKERDDVA 13 VP34_YEAST 99.5% 28.2% --KQVKP--DIKKRDYLNKIINYPPGTKLTAHEKGSIWKYR-YYLMNNKKALT----------KLLQ--STNLREESERV 14 STT4_YEAST 97.3% 10.8% --IEGADS-NELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHA----LMCVGSPSALD-LFIKGSHLS-SK 15 CAVPS34_1 100.0% 23.0% -DKELKP--TPQLRDELLRIMIKPSNAESTDNEKNLIWKFRYYFSKNNSGNDPSNKSVKSFLPKFLR--SINWENDYELD 16 f39b11 98.9% 21.8% --QDFAT-LDIETQEYLLELIENQDTSTLETDDQDLIWQKR-LHLTNQPEALP----------LVLS-SLQDWSFGF-VM 17 HSC2PI3K_1 98.4% 23.2% -RYEFGS-LREEDQRKLKDIMQKESLYWLTDADKKRLWEKR-YYCHSEVSSL-----------PLVLASAPSWEWAC-LP 18 CEUB0025_3 100.0% 27.5% RHRQVKP--NKQAKDRLETIVNLPSSQVLTREQRDLVWKFR-HYLRQFPKALN----------KYLR--SVNWVHPQEVK 19 dmu52192_1 97.8% 20.7% --YDFAS-LDANLQEELLDTA--ELGYTGATERREVFWEKR-LYLQSYPNALP----------KVLH-AAHSWDYAN-LI 20 P3K1_DICDI 98.4% 27.3% --PPTNIN-SNEMREFFEQITALDPLSDLKQEKYNQLWTLRHYSI-LFPQVLP----------RLML--SVPWTQATAVD 21 HSPITR1_1 100.0% 30.2% -DHDLKP--YPSPRDQLKNIVSYPPSKPPTYEEQDLVWEFR-YYLTNQDKALT----------KILT--SVIWDLPQGAK 22 P3K2_DICDI 98.9% 27.7% --VGLKK-LDLDEARRLKALMDSDPLVQLSAEDKKLVYGYRHIYK-SKPKALA----------KFLL--SVNWIDPDQVT 23 P3K3_DICDI 98.9% 30.7% --NELPV-VTMEEMDRVEQIILQDPLYSLNKEERLLIWKSRYFCH-TKPQALS----------KLLQ--SVEWTNYKQVG 24 P3K4_DICDI 99.5% 40.0% -HKDLKP--NSTELKGNSDILKQPPNTKVTSKEALLIWRFR-YYLTNNKKALT----------KFLR--CVEWSESHQKN consensus/100% .....................................h..c........t..............hh......h....... consensus/90% ...t.t..........h..hh...s...ht.ppt.hlathR........p.h............hl......Wt..p.h. consensus/80% ...pht...t.p.tp.h.tlht..s...lptpcpthlWphR.hhh.p..psls..........phL...sh.Wp..p.ht consensus/70% ..hphps..s.p.pc.lptlhphss..tlstc-pphlWchR.hhh.p.scuLs..........KhL...slpWpp.ptss cov pid 81 . 1 . . . . : . 160 1 PI3K_ARATH 100.0% 100.0% QAIQLMYKW-----EMIDVCDALELLSPLFES----------------------------------EEVRAYAVSVLER- 2 CRU97662_1 99.5% 49.2% QAAELMRQW-----APISAADALELLSPDFRS----------------------------------EVVRQHAVQALQA- 3 VP34_SCHPO 99.5% 44.3% QALSLLDSW-----TEIDIDDALELLSPSFVH----------------------------------PKVRAYAVSRLET- 4 CEU56101_1 98.9% 20.8% ELYVMLEKW-----KPPSVAAALTLLGKRCTD----------------------------------RVIRKFAVEKLNEQ 5 HSU57843_1 99.5% 27.1% PDALPAVSW-----PELPVLSALELLDFSFPD----------------------------------CHVGSFAIKSLRK- 6 P11A_HUMAN 99.5% 27.1% QMYCLVKDW-----PPIKPEQAMELLDCNYPD----------------------------------PMVRGFAVRCLEKY 7 DMPI3K59F_1 99.5% 33.2% QALWMLANW-----APMDVEDALELLSPTFTH----------------------------------PQVRKYAVSRLAQ- 8 P11B_HUMAN 100.0% 28.3% QLQALLQIW-----PKLPPREALELLDFNYPD----------------------------------QYVREYAVGCLRQ- 9 mm52193_1 98.4% 27.3% KTYSLLHQW-----PPLCPLAALELLDAKFAD----------------------------------QGVRSLAVSWMEA- 10 PI4K_HUMAN 95.7% 16.6% PELSHVLCW-----APTDPPTGLSYFSSMYPP---------------------------------HPLTAQYGVKVLRS- 11 P11G_HUMAN 98.4% 29.5% KTYQLLARREVWDQSALDVGLTMQLLDCNFSD----------------------------------ENVRAIAVQKLES- 12 DMPHOS3KI_ 99.5% 25.0% DMWYLLKQW-----PLISIERSLELLDYAYPD----------------------------------PAVRRFAIRCLHF- 13 VP34_YEAST 99.5% 28.2% EVLELMDSW-----AEIDIDDALELLGSTFKN----------------------------------LSVRSYAVNRLKK- 14 STT4_YEAST 97.3% 10.8% KDLHATLYW-----APVSPLKSINLFLPEWQGN---------------------------------SFILQFSIYSLES- 15 CAVPS34_1 100.0% 23.0% HTFKEIIPFYWN-VDKLQIGDALELLGDYFNPYTLGKPTYQDDSMTSKSSKMKSDEKRFIKIYNNVCFLRKLAVERLKL- 16 f39b11 98.9% 21.8% RVYQILEEW-----APLRPEIAMEFLLPKYPD----------------------------------ERIRAHAVQSLAR- 17 HSC2PI3K_1 98.4% 23.2% DIYVLLKQW-----THMNHQDALGLLHATFPD----------------------------------QEVRRMAVQWIGS- 18 CEUB0025_3 100.0% 27.5% TALALMNDW-----ELIEAEDALELLSSAFTH----------------------------------PAVRAYSVSRLLEA 19 dmu52192_1 97.8% 20.7% DLHALLHSW-----APLSPLQSLELLLPRYPD----------------------------------AKVREKAVEWISK- 20 P3K1_DICDI 98.4% 27.3% EAISLLDRW-----PKLKPYESLELLDAKHAN----------------------------------RKVREFAVTCLED- 21 HSPITR1_1 100.0% 30.2% QALALLGKW-----NPMDVEDSLELISSHYTN----------------------------------PTVRRYAVARLRQ- 22 P3K2_DICDI 98.9% 27.7% DAYRQMNDW-----ALLKPVQALEILDAKFAD----------------------------------EHVRNFAIKIINS- 23 P3K3_DICDI 98.9% 30.7% EAFQLLKIW-----PTLSAVDALELLDPKFAD---------------------------------CVEIREYTVKCLDQ- 24 P3K4_DICDI 99.5% 40.0% EALSIMPKW-----DPIDIADSLELLSSAFTHK-------------------------------NTIMVRRYAVEILKP- consensus/100% .....h..h............shthh...h......................................hhthsl..h... consensus/90% p.h..h..W.......hp..tuhpll...a.t....................................ltthult.lt.. consensus/80% phh.hh.pW.....s.hp..puLpLLsstass....................................lRthAVphLpt. consensus/70% pshtlhtpW.....s.lss.puLELLsspass...................................hVRpaAVptLpp. cov pid 161 . . . 2 . . . . 240 1 PI3K_ARATH 100.0% 100.0% ADDEELQCYLLQLVQALRFE------------------------------------------------------------ 2 CRU97662_1 99.5% 49.2% VEVEELGAYLLQLVQALRYE------------------------------------------------------------ 3 VP34_SCHPO 99.5% 44.3% ASNEELLLYLLQLVQALRYDN-------------------------------------------------------PISS 4 CEU56101_1 98.9% 20.8% LSPVTFHLFILPLIQALKYE------------------------------------------------------------ 5 HSU57843_1 99.5% 27.1% LTDDELFQYLLQLVQVLKYE------------------------------------------------------------ 6 P11A_HUMAN 99.5% 27.1% LTDDKLSQYLIQLVQVLKYE------------------------------------------------------------ 7 DMPI3K59F_1 99.5% 33.2% APDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDN--XX----------------CDSNSNALMLAEGI 8 P11B_HUMAN 100.0% 28.3% MSDEELSQYLLQLVQVLKYE------------------------------------------------------------ 9 mm52193_1 98.4% 27.3% ISDDELADLLPQFVQALKYE------------------------------------------------------------ 10 PI4K_HUMAN 95.7% 16.6% FPPDAILFYIPQIVQALRYD------------------------------------------------------------ 11 P11G_HUMAN 98.4% 29.5% LEDDDVLHYLLQLVQAVKFE------------------------------------------------------------ 12 DMPHOS3KI_ 99.5% 25.0% LKDEDLLLYLLQLVQAIKHE------------------------------------------------------------ 13 VP34_YEAST 99.5% 28.2% ASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKS------ISSESETSGTE 14 STT4_YEAST 97.3% 10.8% QDVNLAFFYVPQIVQCLRYD------------------------------------------------------------ 15 CAVPS34_1 100.0% 23.0% ANSEELLLYLLQLVQALKYEALIYEKSPPFCERSDQIEDNA--------------------------------------- 16 f39b11 98.9% 21.8% GSTDFLYHTIPQFIEALRFE------------------------------------------------------------ 17 HSC2PI3K_1 98.4% 23.2% LSDAELLDYLPQLVQALKYE------------------------------------------------------------ 18 CEUB0025_3 100.0% 27.5% ASPEQVLLYLPQLVQALKYE---------------QGQQLPEEGNPVPVVSEEEGKIPSVATTPTEELEGRDMTVVTKKE 19 dmu52192_1 97.8% 20.7% MPNDQLVDFLPQLVQSLKHD------------------------------------------------------------ 20 P3K1_DICDI 98.4% 27.3% LSEDELLDILLQLVQVLKYE------------------------------------------------------------ 21 HSPITR1_1 100.0% 30.2% ADDEDLLMYLSQLVQALKYENFDDIKNGLEPTKKDSQSSVSGNVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVP 22 P3K2_DICDI 98.9% 27.7% FSDAEFSDFLLQLTQVLKYE------------------------------------------------------------ 23 P3K3_DICDI 98.9% 30.7% MSDYELEIYLLQLVQAIKHD------------------------------------------------------------ 24 P3K4_DICDI 99.5% 40.0% ADDEELLYYLLQLVQATKYEQFD--------------------------------------------------------- consensus/100% .....h..hl..hhpshpa-............................................................ consensus/90% h.stth..hl.QllQsl+a-............................................................ consensus/80% hssppl..aL.QLVQsl+a-............................................................ consensus/70% hss--Lh.YL.QLVQALKYE............................................................ cov pid 241 : . . . . 3 . ] 316 1 PI3K_ARATH 100.0% 100.0% --RSDRSCLSQFLVQRALQNI-ELASFLRWYVAVEL------HDHVY----AKRFYSTYELLEENI-INWPPGVNG 2 CRU97662_1 99.5% 49.2% -AADTGSRLGAFLVQRAAEDP-ALAVQLHWYLFCEL------DDPGF-----GLRARALHTLLLDTLAGGGPRSPG 3 VP34_SCHPO 99.5% 44.3% DERFQPSPLALFLVNRAISSP-SIGNDLYWYLVVEI------EDEP-----VSKLFSSVMFLFQKELSKSVEGRLI 4 CEU56101_1 98.9% 20.8% --PRAQSEVGMMLLTRALCDY-RIGHRLFWLLRAEI---ARLRDCDLKSEEYRRISLLMEAYLRGN-EEHIKIITR 5 HSU57843_1 99.5% 27.1% --SYLDCELTKFLLERALANR-KIGHFLFWHLRSEM------HVPSV----ALRFGLILEAYCRGSTHHMKVLMK- 6 P11A_HUMAN 99.5% 27.1% --QYLDNLLVRFLLKKALTNQ-RIGHFFFWHLKSEM------HNKTV----SQRFGLLLESYCRAC-GMYLKHLNR 7 DMPI3K59F_1 99.5% 33.2% SFGSVPANLCTFLIQRACTNA-TLANYFYWYLSIEVEEVESVRKQDER--AHDMYAMVLKMFLKVL-ENGNFNLRG 8 P11B_HUMAN 100.0% 28.3% --PFLDCALSRFLLERALGNR-RIGQFLFWHLRSEV------HIPAV----SVQFGVILEAYCRGS-VGHMKVLSK 9 mm52193_1 98.4% 27.3% --IYLNSSLVRFLLSRALGNI-QIAHSLYWLLKDAL------HDTHF----GSRYEHVLGALLSVG-GKGLREELS 10 PI4K_HUMAN 95.7% 16.6% ----KMGYVREYILWAASKSQ-LLAHQFIWNMKTNI---YLDEEGHQK---DPDIGDLLDQLVEEITGSLSGPAKD 11 P11G_HUMAN 98.4% 29.5% --PYHDSALARFLLKRGLRNK-RIGHFLFWFLRSEIA-----QSRHY----QQRFAVILEAYLRGC-GTAMLHDFT 12 DMPHOS3KI_ 99.5% 25.0% --SYLESDLVVFLLERALRNQ-RIGHYFFWHLRSEM------QTPSM----QTRFGLLLEVYLKGC-KHHVAPLRK 13 VP34_YEAST 99.5% 28.2% SLPIVISPLAEFLIRRALVNP-RLGSFFYWYLKSES------EDKPY----LDQILSSFWSRLDKK-SRNILNDQV 14 STT4_YEAST 97.3% 10.8% ----KTGYVERLILDTAKISV-LFSHQIIWNMLANCYKDDEGIQEDE---IKPTLDRIRERMVSSF-SQSHRDFYE 15 CAVPS34_1 100.0% 23.0% -SSTLKSPLADFLIERAVENE-KLGNFFYWYVKVEN--EDQLNNPHI----DGPIKIYMDILNRYI-ELLKAHCHE 16 f39b11 98.9% 21.8% --LYEKSALADFILELSFVSL-DFTFEIYWQLQQRV-DHCAVDDLPY----AIRCQNLQQKMIDEHENPNLKTDIK 17 HSC2PI3K_1 98.4% 23.2% --CYLDSPLVRFLLKRAVSDL-RVTHYFFWLLKDGL------KDSQF----SIRYQYLLAALLCC-CGKGLREEFN 18 CEUB0025_3 100.0% 27.5% ARKAASGDLATFLIDYALASP-KVSNYLYWHLKTEI---ESTKESKEEH--SKMYQNIQDRLMEAL-VKRPDTRAQ 19 dmu52192_1 97.8% 20.7% --TYEGSAMARFLLSKCLESP-RFAHHMYWLLVHSL-----PDDPHN----SIGAAMVDQEYDESQ-VTQVRYYRR 20 P3K1_DICDI 98.4% 27.3% --PFHDSKLSRFLLRKAILNR-NIGHSFFWYLKSDL------HDSNL----SERFGILLESYLYACGAHRIELLK- 21 HSPITR1_1 100.0% 30.2% DGENLEQDLCTFLISRASKNS-TLANYLYWYVIVEC------EDQDT----QQRDPKTHEMYLNVM-RRFSQALLK 22 P3K2_DICDI 98.9% 27.7% --PYHNSDLTHILIQRALSNRSRIGHFFFWFLKSEM------HTPEI----EERYGLLLEGYLRSC-GTHRQDLIK 23 P3K3_DICDI 98.9% 30.7% --VFHNSVLSLFLIGRVWQNMQVLGHPFFWHLRADI------DNQEV----CERFRVLSSGFLRYA-PTQLMESFK 24 P3K4_DICDI 99.5% 40.0% -GNPSDSPLISFLFERSNKNF-ILGSHFYWYLTVDS----VLKSSIF----CSHYKTLQELYFRQLDHTDAQRVN- consensus/100% ......t.h..hlh.hs..s...hs..hhW.h..t..........................h.............. consensus/90% ......s.l..hllptu..s...hup.hhW.lh.p.......pp..........h..h.t.h.p............ consensus/80% .....tu.LstFLlp+uhts..tlup.haWhlhsph......cp.......t.tht.h.p.hhp....t....... consensus/70% ...hhpusLspFLlpRAhts..plup.haWaLps-h......cs.ph....ttphthlhcthhcsh.tpthtthht