cov pid 1 [ . . . . : . . . 80 1 ESR1_YEAST 100.0% 100.0% GIMCKK-EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLK---- 2 DM52192_1 85.6% 14.1% PAIFKCGDDLQQDQLTIQLIRIMNKMWLAE----RLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQV----------- 3 YAMB_SCHPO 97.9% 12.8% ALQYPATRHSRREERMLQLLGTFNTVLRSKIEIQNRNFSFQIPSSIPLSSHMRIIADKPSYVTMQTISDEYCKNRGMPLD 4 HSU76308_1 96.9% 34.7% IMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMT 5 HS349941_1 95.5% 19.2% PFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPC-EYKDWLTKMSGKHDVGAY--- 6 P3K1_SOYBN 82.2% 19.4% KIIFKKGDDLRQDQLVVQMVSLMDRLLKLE----NLDLHLTPYKVLATGQDEGMLEFIP-SRSLAQILSENRS------- 7 VP34_SCHPO 82.5% 17.9% PIIFKNGDDLRQDQLVIQILTLMDKLLKKE----KLDLHLKPYRILATGPTHGAVQFVP-SKTLATILAEYHG------- 8 CEU56101_1 88.0% 16.6% AMIFKNGDDLRQDMLVLQVLEVMDNIWKAA----NIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQV----------- 9 P11A_HUMAN 86.6% 17.6% EIIFKNGDDLRQDMLTLQIIRIMENIWQNQ----GLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQ------------ 10 P11B_HUMAN 87.0% 18.1% GVIFKNGDDLRQDMLTLQMLRLMDLLWKEA----GLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQL----------- 11 YHP9_YEAST 96.6% 13.2% AVQYPAVRHSRREERMFQLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIHNEFCKKKGFDPD 12 FRAP_RAT 95.9% 25.7% VFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN 13 PI4K_HUMAN 83.6% 15.2% AAIFKVGDDCRQDMLALQIIDLFKNIFQLV----GLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLG------------ 14 CEC47D12_5 97.6% 11.4% AFYLKKSVQDEPTNRVPQMFKHLDHVLQTDRESARRHLHAPTVLQMRVGQKTTLYEVASVQPYAMPPDCTRNYPASQIDI 15 P11G_HUMAN 86.3% 17.4% GIIFKHGDDLRQDMLILQILRIMESIWETE----SLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ------------ 16 DMPHOS3KI_ 87.0% 18.3% HIIFKNGDDLRQDMLTLQMLRVMDQLWKRD----GMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQ------------ 17 STT4_YEAST 83.6% 17.8% AAIFKVGDDCRQDVLALQLISLFRTIWSSI----GLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLG------------ 18 PI4K_DICDI 84.6% 18.5% SVIVKTGDDCRQEQMAVQLISKFDEIWKET----RLPLYLRPYSILVTSSGGGIIETIPDTMSLHNLKK----------- 19 HSC2PI3K_1 85.3% 15.4% RVIFKCGDDLRQDMLTLQMIRIMSKIWVQE----GLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQV----------- 20 CEUB0025_3 82.2% 17.0% TVIFKTGDDLRQDQLIQQMVRLIDIILKKG----QLDLKLTPYLVLSTGVGQGFVQCIKSKPLRAIQEQ----------- 21 CEUB0261_2 95.5% 24.3% QFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVK----------- 22 TEL1_YEAST 98.3% 29.8% ALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDK---- 23 P3K1_DICDI 86.0% 18.2% EVIFKAGDDLRQDMLTLQMIRLMDKLWQKE----GLDLKLSPYGCISTGDMIGMIEVVLNSETTAKIQ------------ 24 P3K2_DICDI 86.0% 17.2% TVIFKVGDDLRQDILTLQVLRIMDKFWKNS----GMDLRLQPYKCIATGDGIGMLEVVLNANTIANIN------------ 25 2198789 82.9% 15.3% SVIVKCGDDLRQELLAFQVLKQLQSIWEQE----RVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKK----------- 26 P3K3_DICDI 86.0% 18.5% QMIAKTGDDLRQDILTLQLLRLMDHMWKSQ----DLDLHMTIYRCIATGMGTGLIEVVPNSETAARIQ------------ 27 CEF39B1_1 85.6% 17.1% SIIHKRDDDMRQDAFVMKMLNEMDRIWKSN----GLDLRMITFRIMPVGYRRGMGELVLNCATLMEIQK----------- 28 P3K4_DICDI 82.9% 19.0% GVIFKTNDDLRQDQLIIQLISLMDRLLKKE----NLDLKLTPYKVLATAEEDGIVEMVNPSEAMASVLSKYDG------- 29 YDBG_SCHPO 89.4% 16.7% SVIVKTGADLRQETFACQLIYAFQRVWLEC----KEKVWVRRMKILVTGDNSGLIETITNAISVHSIKKNLTKQLR---- 30 DM34925_2 94.2% 30.7% DVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMS 31 TOR1_YEAST 95.2% 26.8% KYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLN 32 MMU43678_1 99.0% 26.8% RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAH---- 33 CET06E4_4 98.3% 24.7% RLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTS---- 34 SPU76307_1 95.5% 32.2% PFLCKPKDDLRKDARLMEFNNLICKILRKDQEANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPIS 35 CEF35H12_2 87.7% 18.8% PVIVKTGDDLSQEAFAQQLLFTFKDLWHEE----GVPLYLRPYKIVCIGSDAGLIEPVLDTLSLHQIKR----------- 36 CEUC48B6_3 84.2% 6.9% AFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKA 37 PIK1_YEAST 89.4% 17.3% SVIAKTGDDLRQEAFAYQMIQAMANIWVKE----KVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMI---- 38 HSPITR1_1 82.2% 17.4% PVIFKHGDDLRQDQLILQIISLMDKLLRKE----NLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVLDTE--------- consensus/100% ...h....p.p.p..h.ph...ht..h..........h.h.....h.h.....h.........h................ consensus/90% .hhhK.tcD.cp-.hh.phhthhp.hh.tt....thth.h..h.hhshs.t.shht.h....shh.h............. consensus/80% .hlhKst-DhRp-.hhhQhhphhpplhtpp....thslth..athlshu.t.Ghlphl.ps.shtpl............. consensus/70% shlhKssDDLRQD.hhhQhhphhsplhppp....phcLphp.YtslshutptGhlEhl.ss.ohtpl............. cov pid 81 . 1 . . . . : . 160 1 ESR1_YEAST 100.0% 100.0% --------------------------IKYSLKSLHDRWQHTAVDGKLEFYMEQVD-KFPPILYQWFLENFPDP------- 2 DM52192_1 85.6% 14.1% -------------------------------------------------ECGLTGSFKDRPIAEWLGKQNPSPL------ 3 YAMB_SCHPO 97.9% 12.8% YGIRFYFDRLQTGLIQLKRASASMLSNSTVEEKKQIFRQRALQLRMQLLETLNSSVFPESIYYDYFYKTFERY------- 4 HSU76308_1 96.9% 34.7% GKELRQ----------------------------CMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDP------- 5 HS349941_1 95.5% 19.2% ----------------------------------MLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSP------- 6 P3K1_SOYBN 82.2% 19.4% -------------------------------------------------------------IISYLQKFHPDDH------ 7 VP34_SCHPO 82.5% 17.9% ------------------------------------------------------------SVLAYLRENNPDDGLN---- 8 CEU56101_1 88.0% 16.6% ---------------------------------------------GTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSK 9 P11A_HUMAN 86.6% 17.6% ----------------------------------------------CKGGLKGALQFNSHTLHQWLKDKNKGE------- 10 P11B_HUMAN 87.0% 18.1% ----------------------------------------------NSSNVAAAAAFNKDALLNWLKEYNSGD------- 11 YHP9_YEAST 96.6% 13.2% DIQDFMADKLNA------------------AHDDALPAPDMTILKVEIFNSIQTMFVPSNVLKDHFTSLFTQF------- 12 FRAP_RAT 95.9% 25.7% IEHRIMLRM-------------------------APDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSS------- 13 PI4K_HUMAN 83.6% 15.2% -------------------------------------------------------RQTDFGMYDYFTRQYGDEST----- 14 CEC47D12_5 97.6% 11.4% VH----XX----AQSSSSIGQPLPTPTNQDGTVAPPRLTEAHHIKNIIYEDFARDMIPFRLLYDYLTARYPDP------- 15 P11G_HUMAN 86.3% 17.4% -----------------------------------------------QSTVGNTGAFKDEVLNHWLKEKSPTEE------ 16 DMPHOS3KI_ 87.0% 18.3% ---------------------------------------------KEKGMFSATSPFKKGSLLSWLKEHNKPAD------ 17 STT4_YEAST 83.6% 17.8% -------------------------------------------------------REAVNGLYEYFTSKFGNEST----- 18 PI4K_DICDI 84.6% 18.5% ------------------------------------------------------STPGFTTLLNYFKSTYGDPSG----- 19 HSC2PI3K_1 85.3% 15.4% -------------------------------------------------EHGVTGSFKDRPLADWLQKHNPGED------ 20 CEUB0025_3 82.2% 17.0% -----------------------------------------------------YKAHKMDCIREAMKELRPGDGP----- 21 CEUB0261_2 95.5% 24.3% -------------EYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSE------ 22 TEL1_YEAST 98.3% 29.8% -------------------------ITFDQARKGMKAVQTKSNEERLKAYLKITN-EIKPQLRNFFFDSFPDP------- 23 P3K1_DICDI 86.0% 18.2% -----------------------------------------------KSEGGGAFRFQVGSFGQLILQHNKSDM------ 24 P3K2_DICDI 86.0% 17.2% -----------------------------------------------KDAGGTGALLEEKTLVNWLKECNKTEA------ 25 2198789 82.9% 15.3% --------------------------------------------------------QSQLSLLDYFLQEHGSYTT----- 26 P3K3_DICDI 86.0% 18.5% -----------------------------------------------AGAGGVSGAFKQTPIANWLKNHNQTEN------ 27 CEF39B1_1 85.6% 17.1% -------------------------------------------------EEGLRGVLNDEILRKWLMKHNSDEF------ 28 P3K4_DICDI 82.9% 19.0% ------------------------------------------------------------DILKFFKTHNPDAD------ 29 YDBG_SCHPO 89.4% 16.7% ---------------------------------------------EAELAQGKIAGKNVVTLKDYFIKQFGDPNS----- 30 DM34925_2 94.2% 30.7% TRQLQS----------------------------LAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATP------- 31 TOR1_YEAST 95.2% 26.8% IEHWVMLQM-------------------------APDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSS------- 32 MMU43678_1 99.0% 26.8% -------------------RRYRPNDFSANQCQKKMMEVQKKSFEEKYDTFMTICQNFEPVFRYFCMEKFLDP------- 33 CET06E4_4 98.3% 24.7% ------------------------GEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEA------- 34 SPU76307_1 95.5% 32.2% YQEIK-----------------------------VDLDFALRSPNPGDIFEKKILPKFPPVFYEWFVESFPEP------- 35 CEF35H12_2 87.7% 18.8% ---------------------------------------------HLTNVFRMNGNVTTPSLKHHFENVFGPVN------ 36 CEUC48B6_3 84.2% 6.9% LKQATKKNGETVPEIERPSNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATT 37 PIK1_YEAST 89.4% 17.3% -----------------------------------------------EDAELDDKGG-IASLNDHFLRAFGNPNG----- 38 HSPITR1_1 82.2% 17.4% -----------------------------------------------------------GSIQNFFRKYAPSEN------ consensus/100% .............................................................h...h.............. consensus/90% .............................................................h.phhh............. consensus/80% .............................................................hhpahhpt..s........ consensus/70% ............................................................slhpahhpp.ss........ cov pid 161 . . . 2 . . . . 240 1 ESR1_YEAST 100.0% 100.0% ------------------------------INWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDC 2 DM52192_1 85.6% 14.1% -------------------------------EYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLK-TSGHLFHIDFGK 3 YAMB_SCHPO 97.9% 12.8% ------------------------------CDFWFFRRTFTTQYAYMIIMTYVFNIGGRSPQKLFIVKDSGQVMSQDLLP 4 HSU76308_1 96.9% 34.7% ------------------------------TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNC 5 HS349941_1 95.5% 19.2% ------------------------------EAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGH 6 P3K1_SOYBN 82.2% 19.4% ---------------------------GPFGITATCLETFIKSCAGYSVITYILGIGDRHLDNLLLR-NDGGLFHVDFGF 7 VP34_SCHPO 82.5% 17.9% --------------------------SANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLIT-KDGHFFHADFGY 8 CEU56101_1 88.0% 16.6% KDSTKN------------PIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLT-EDGKYFHIDFGH 9 P11A_HUMAN 86.6% 17.6% -------------------------------IYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVK-DDGQLFHIDFGH 10 P11B_HUMAN 87.0% 18.1% -------------------------------DLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVK-KTGQLFHIDFGH 11 YHP9_YEAST 96.6% 13.2% ------------------------------EDFWLFRKQFASQYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEMLP 12 FRAP_RAT 95.9% 25.7% ------------------------------EVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGD 13 PI4K_HUMAN 83.6% 15.2% ------------------------------LAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLD-KKGHIIHIDFGF 14 CEC47D12_5 97.6% 11.4% ------------------------------VMYYAMKKQLLHSLAVLSTIEYHCNLTPMGPDQMMMTMNTGVLSNPSYRF 15 P11G_HUMAN 86.3% 17.4% -------------------------------KFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMIT-ETGNLFHIDFGH 16 DMPHOS3KI_ 87.0% 18.3% -------------------------------KLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVK-RNGQLFHIDFGH 17 STT4_YEAST 83.6% 17.8% ------------------------------IEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYD-DQGHCLHIDFGF 18 PI4K_DICDI 84.6% 18.5% ------------------------------LRFRTAQSNFIESMAAYSIVTYILQIKDRHNGNILID-KEGHIVHIDFGF 19 HSC2PI3K_1 85.3% 15.4% -------------------------------EYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLK-TTGHMFHIDFGR 20 CEUB0025_3 82.2% 17.0% -----------------------------FGIEPNVIDNYVRSLAGYSVIMYILGLGDRHLDNLLLC-ENGKLFHVDFGF 21 CEUB0261_2 95.5% 24.3% -------------------------------VWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGD 22 TEL1_YEAST 98.3% 29.8% ------------------------------LDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGI 23 P3K1_DICDI 86.0% 18.2% -------------------------------EYQKAVDTFILSCAGYCVATYVLGIGDRHNDNLMVT-KGGRLFHIDFGH 24 P3K2_DICDI 86.0% 17.2% -------------------------------EYNKAVETFILSCAGYVVATYVMGIGDRHSDNIMIT-KLGHLFHIDFGH 25 2198789 82.9% 15.3% ------------------------------EAFLSAQRNFVQSCAGYCLGCYLLQVKDRHNGNILLD-AEGHIIHIDFGF 26 P3K3_DICDI 86.0% 18.5% -------------------------------SYQKAVSKFTLSCAGYCVATYVLGIGDRHNDNIMVD-IHGHLFHIDFGH 27 CEF39B1_1 85.6% 17.1% -------------------------------AYKEAQENFIRSCAGWCIVTYVLGIGDRHNDNILFT-KNGHVFHIDFGK 28 P3K4_DICDI 82.9% 19.0% ---------------------------SPYGIAPEVMDTFVKSCAGYCVITYILGIGDRHLDNLLLT-PNGKLFHIDFGY 29 YDBG_SCHPO 89.4% 16.7% ------------------------------SRYRQAQTNFLQSLVAYSIISYLLQLKDRHNGNVLID-SEGHIIHIDFGF 30 DM34925_2 94.2% 30.7% ------------------------------HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNC 31 TOR1_YEAST 95.2% 26.8% ------------------------------ETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGD 32 MMU43678_1 99.0% 26.8% ------------------------------AVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGV 33 CET06E4_4 98.3% 24.7% ------------------------------GQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVH-TTGKCIHVDFDM 34 SPU76307_1 95.5% 32.2% ------------------------------NNWVTSRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNC 35 CEF35H12_2 87.7% 18.8% -----------------------------SETYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLD-MDGHLIHIDYGF 36 CEUC48B6_3 84.2% 6.9% WWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPSEMY 37 PIK1_YEAST 89.4% 17.3% ------------------------------FKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMID-NEGHVSHIDFGF 38 HSPITR1_1 82.2% 17.4% ---------------------------GPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLVLT-KTGKLFHIDFGY consensus/100% .......................................hh.ths...h..hhh.ht..t...hhh....t...t.p... consensus/90% ................................h.t..ptah.shushshhtahhtltsRc.tslhhp..pGphhphDht. consensus/80% ................................h.thhppahhShAshshhsYlLtltDRHstNlhls..pGphhHlDFsh consensus/70% ...............................ta.pshpsahpShAshslhsYlLGlsDRHssNlhls.psGclhHlDFGh cov pid 241 : . . . . 3 . . 320 1 ESR1_YEAST 100.0% 100.0% LFEKG-KRLPVP-----------------EIVPFRLTPNLLDALG-------IIGTEGTFKKSSEVTLALMRKNEVALMN 2 DM52192_1 85.6% 14.1% FLGDA-QMFGNFK---------------RDRTPFVLTSDMAYVINGG---DKPSTDFHYFVDLCCRAFNIVRKNADLLLH 3 YAMB_SCHPO 97.9% 12.8% SMTSN-QPVFHNT----------------EAVPFRLTPPIQYLIS-------DLGVEGLLSGLVMSIAQSLSSPTTDIKQ 4 HSU76308_1 96.9% 34.7% LFNKG-ETFEVP-----------------EIVPFRLTHNMVNGMG-------PMGTEGLFRRACEVTMRLMRDQREPLMS 5 HS349941_1 95.5% 19.2% AFGSATQFLPVP-----------------ELMPFRLTRQFINLML-------PMKETGLMYSIMVHALRAFRSDPGLLTN 6 P3K1_SOYBN 82.2% 19.4% ILGRD-PKPFP--------------------PPMKLCKEMVEAMG-----GAESQYYTRFKSYCCEAYNILRKSSNLILN 7 VP34_SCHPO 82.5% 17.9% ILGRD-PKLFS--------------------PAMKLSKEMVEGMG-----GYNSPFYQQFKSYCYTTFTALRKSSNLILN 8 CEU56101_1 88.0% 16.6% ILGHG-KTKLGIQ---------------RDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVS 9 P11A_HUMAN 86.6% 17.6% FLDHK-KKKFGYK---------------RERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFIN 10 P11B_HUMAN 87.0% 18.1% ILGNF-KSKFGIK---------------RERVPFILTYDFIHVIQQG--KTGNTEKFGRFRQCCEDAYLILRRHGNLFIT 11 YHP9_YEAST 96.6% 13.2% SRFPYERVKPLLKNHDLSLPPDSPIFHNNEPVPFRLTPNIQSLIG-------DSALEGIFAVNLFTISRALIEPDNELNT 12 FRAP_RAT 95.9% 25.7% CFEVA-MTREKF----------------PEKIPFRLTRMLTNAME-------VTGLDGNYRTTCHTVMEVLREHKDSVMA 13 PI4K_HUMAN 83.6% 15.2% MFESS-PGGNLG-----------------WEPDIKLTDEMVMIMGG----KMEATPFKWFMEMCVRGYLAVRPYMDAVVS 14 CEC47D12_5 97.6% 11.4% EIRGG-RSLHDIQHFGH------------EVPFRLTPNLSILVGV--------AQDGDLLWSMAAASKCLMKKEPEVIMR 15 P11G_HUMAN 86.3% 17.4% ILGNY-KSFLGIN---------------KERVPFVLTPDFLFVMGTSG--KKTSPHFQKFQDICVKAYLALRHHTNLLII 16 DMPHOS3KI_ 87.0% 18.3% ILGHF-KEKLGVR---------------RERVPFVLTHDFVYVINKG-FNDRESKEFCHFQELCERAFLVLRKHGCLILS 17 STT4_YEAST 83.6% 17.8% IFDIV-PGGIKF-----------------EAVPFKLTKEMVKVMGG----SPQTPAYLDFEELCIKAYLAARPHVEAIIE 18 PI4K_DICDI 84.6% 18.5% ILSNS-PGNISF-----------------ESAPFKLTQELVDVMGG-----IQSGQFQYFKVLCVRGLIEARKQVDKIIS 19 HSC2PI3K_1 85.3% 15.4% FLGHAQMFGNIKR----------------DRAPFVFTSDMAYVINGG---DKPSSRFHDFVDLCCQAYNLIRKHTHLFLN 20 CEUB0025_3 82.2% 17.0% ILGRD-PKPMPP--------------------PMKLTSEMVQVMG-----GVKSKQFLEFVQHVDSAYRILRRHSNVLLN 21 CEUB0261_2 95.5% 24.3% CFEVA-MLREKFP----------------ERVPFRLTRMLINAMEVT-------GLDGVYNYTAERVLKMLRTNQESLLA 22 TEL1_YEAST 98.3% 29.8% AFDQG-KLLPIP-----------------ELVPFRLTRDIVDGFG-------VTGVDGLFRRSCERVYAVLRKDYVKVMC 23 P3K1_DICDI 86.0% 18.2% FLGNY-KKKFGFK---------------RERAPFVFTPDFCYVMG-----GKESFKFSQFVNYCCTGYNIVRKNAKLFMN 24 P3K2_DICDI 86.0% 17.2% FLGNY-KKKYGFK---------------RERAPFIFTPQYMAIVG-----GKDSENFKRFVTTCCSAYNILRKNTDLFIN 25 2198789 82.9% 15.3% ILSSS-PRNLGFE-----------------TSAFKLTTEFVDVMG-----GLDGDMFNYYKMLMLQGLIAARKHMDKVVQ 26 P3K3_DICDI 86.0% 18.5% FLGNF-KTFAGFQ---------------REKAPFVLTPDFVYVIG-----GKDSPNFAFFVDICCKAFNIIRSNAHVFIN 27 CEF39B1_1 85.6% 17.1% YMGDW-QMAAGFR---------------RDRVPFVFTTEMFHVINNG---RAPTQYNQKFIDYCCKAFNHLRRNKNTLTN 28 P3K4_DICDI 82.9% 19.0% ILGKD-PKILP--------------------PPMKLCKEMVLGMG-----GENSKHYEKFKQLCCEAYNILRKSSHLILN 29 YDBG_SCHPO 89.4% 16.7% LLTNT-PGNVGF-----------------ESAPFKLTADYLEIL---------DDRFDEYRSLMKAAFKSVRKNADQIIL 30 DM34925_2 94.2% 30.7% LFNQG-ELLPYP-----------------EVVPFRLTHNMIVAMG-------PLGVEGSFRKCCEITLRLLKQESKTLMS 31 TOR1_YEAST 95.2% 26.8% CFEAA-ILREKYP----------------EKVPFRLTRMLTYAME-------VSGIEGSFRITCENVMRVLRDNKESLMA 32 MMU43678_1 99.0% 26.8% AFEQG-KILPTP-----------------ETVPFRLSRDIVDGMG-------ITGVEGVFRRCCEKTMEVMRSSQETLLT 33 CET06E4_4 98.3% 24.7% IFNKG-ETLGTP-----------------ELVPFRLTQNMINGMG-------EVALDGEFRTVCEQALRVFRENSYEIEK 34 SPU76307_1 95.5% 32.2% LFDKG-LTFEKP-----------------EKVPFRLTHNMVDAMG-------PTGYEGGFRKASEITMRLLRSNQDTLMS 35 CEF35H12_2 87.7% 18.8% LLSSS-PRNLGF-----------------ETAPFKLTTEIIDVMGG-----IDSDMFLYFKSLLLRGLMAARKHHRRIVS 36 CEUC48B6_3 84.2% 6.9% GTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDWTSHEHTATSGVSLALQLAVYGSNWKTKAKERLTDAMELLNLRMS 37 PIK1_YEAST 89.4% 17.3% MLSNS-PGSVGF-----------------EAAPFKLTYEYIELLGG-----VEGEAFKKFVELTKSSFKALRKYADQIVS 38 HSPITR1_1 82.2% 17.4% ILGRD-PKPLPP--------------------PMKLNKEMVEGMGGT-----QSEQYQEFRKQCYTAFLHLRRYSNLILN consensus/100% .h...............................h.hs.....hh...............h..........h......h.. consensus/90% hht.............................shhhs..hh.hht............t.a...h..sh..hpp..t.hht consensus/80% hhtp...h.......................sPhhLT.phh.shs........st..t.ahphs.psh.hhRpp.p.hhp consensus/70% hhsps..hh.h..................-hsPFhLTpphl.shs........st..t.Ftphs.pshthhRcptphlhs cov pid 321 . . : . . . . 4 400 1 ESR1_YEAST 100.0% 100.0% VIETIMYDRNMDHSIQK---------------ALKVLRNKIRGID-------PQDGLVLSVAGQT--ETLIQEATSEDNL 2 DM52192_1 85.6% 14.1% TLAHMATAGM-PGVNSN---------------AVQYVRRALLPS--------QSNPEAAATFAK------MIQSSLKSWF 3 YAMB_SCHPO 97.9% 12.8% YLSLYVRDEV-FWWSKQ-------------QRKPIPQGIQLFETV------KVNVELLFRRI-------SVISHNVPEDL 4 HSU76308_1 96.9% 34.7% VLKTFLHDPL-VEWSKP-----------VKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHV 5 HS349941_1 95.5% 19.2% TMDVFVKEPS-FDWKNF------------EQKMLKKGGSWIQEIN-------VAEKNWYPRQ-----KICYAKRKLAGAN 6 P3K1_SOYBN 82.2% 19.4% LFYLMAGSNI-PDIASD------------PEKGILKLQEKFRLD--------LDDEASIHFFQD------LINESVSALF 7 VP34_SCHPO 82.5% 17.9% LFSLMVDANI-PDIKFD------------KEKVVYKVKERFCLQ--------MSESDAIKYFEQ------LINDSVSALF 8 CEU56101_1 88.0% 16.6% LFTLMLGMEL-PELSTK--------------ADLDHLKKTLFCNG-------ESKEEARKFFAG-----IYEEAFNGSWS 9 P11A_HUMAN 86.6% 17.6% LFSMMLGSGM-PELQSF--------------DDIAYIRKTLALD--------KTEQEALEYFMK-----QMNDAHHGGWT 10 P11B_HUMAN 87.0% 18.1% LFALMLTAGL-PELTSV--------------KDIQYLKDSLALG--------KSEEEALKQFKQ-----KFDEALRESWT 11 YHP9_YEAST 96.6% 13.2% YLALFIRDEI-ISWFSN-------------LHRPIIENPQLREMV------QTNVDLIIRKV-------AQLGHLNSTPT 12 FRAP_RAT 95.9% 25.7% VLEAFVYDPL-LNWRLM------------DTNAKGNKRSRTRTDS-------YSAGQSVEIL-----DGVELGEPAHKKT 13 PI4K_HUMAN 83.6% 15.2% LVTLMLDTGL-PCFRGQ---------------TIKLLKHRFSPN--------MTEREAANFIMK------VIQSCFLSNR 14 CEC47D12_5 97.6% 11.4% PLVWDEFANN-TDCDKS-------------VFACHASNSYINGVA------SKLRNTNSADA-------KLRKDDCVSLI 15 P11G_HUMAN 86.3% 17.4% LFSMMLMTGM-PQLTSK--------------EDIEYIRDALTVG--------KNEEDAKKYFLD-----QIEVCRDKGWT 16 DMPHOS3KI_ 87.0% 18.3% LFSMMISTGL-PELSSE--------------KDLDYLRETLVLD--------YTEEKAREHFRA-----KFSEALANSWK 17 STT4_YEAST 83.6% 17.8% CVNPMLGSGL-PCFKGH--------------KTIRNLRARFQPQ--------KTDHEAALYMKA------LIRKSYESIF 18 PI4K_DICDI 84.6% 18.5% LIEIMMSGPKMSCFVGG-------------KEVIEQLKARFFLD--------VNERECSTLVEN------LISYSIDHFK 19 HSC2PI3K_1 85.3% 15.4% LLGLMLSCGI-PELSDL-------------EDLKYVYDALRPQD---------TEANATTYFTR------LIESSLGSVA 20 CEUB0025_3 82.2% 17.0% LFSLMLDAGI-PDIAAEP------------DKAIFKIEQRLRLD---------LSDEAATKH--------IFTQI-ESSL 21 CEUB0261_2 95.5% 24.3% VLEAFVYDPV-INWRLVEGMKKDPKTRKDTGGRQNMAGAVLPSS--------STTDSIMETIKRKLDGTEFVHTD-GSTP 22 TEL1_YEAST 98.3% 29.8% VLNILKWDPL-YSWVMS---------------PVKKYEHLFEEEH-----EITNFDNVSKFISN------NDRNENQESY 23 P3K1_DICDI 86.0% 18.2% LFAMMVSTGI-PELQSM--------------EDLNYLKESFSIE--------LSDAKAREKFVA-----LIHESL-ATKT 24 P3K2_DICDI 86.0% 17.2% LFQLMLSTGI-PELQVA--------------EDIDYLRKALAPG--------LSDEEAAEEFTK-----NISVAL-NTKT 25 2198789 82.9% 15.3% IVEIMQQGSQLPCFHGSST---------I-RNLKERFHMSMTEE--------QLQLLVEQMV---------DGSMRSITT 26 P3K3_DICDI 86.0% 18.5% MFELMLSTGI-PELRSE--------------NDIVYLRDKFRLD--------LTDAEASEYFKK-----LIHESI-GTLT 27 CEF39B1_1 85.6% 17.1% LLRIMACSDI-PGINMD---------------SLAFVENNLMLD--------LSDTDATVQFTA------MIQNSLGSAF 28 P3K4_DICDI 82.9% 19.0% LFALMVDASI-PSISDD------------KEKSILKVQEKLQLE--------LTDQEASNSLLQ------LLNDSVTALF 29 YDBG_SCHPO 89.4% 16.7% LVEVMQNNSTMPCFRAG-------------ENTSAQLLQRFQLQ--------LGDKECDDFVDL------LIQKANCSVW 30 DM34925_2 94.2% 30.7% ILRPFVYDVG-AQTRKGAA---------TAKITKDVQRIADRLQG-------HVKRQQANS----------IPLSTEGQV 31 TOR1_YEAST 95.2% 26.8% ILEAFALDPL-IHWGFD------------LPPQKLTEQTGIPLPL-------INPSELLRKG-------AITVEEAANME 32 MMU43678_1 99.0% 26.8% IVEVLLYDPL-FDWTMN-------------PLKALYLQQRPEDE---------SDLHSTPNADDQ-ECKQSLSDTDQSFN 33 CET06E4_4 98.3% 24.7% YIADLPNLVADFPSNKR--------------APKDFDMSEAKRL--------VSGRLRGQIMTA-----KLYRSNPISHP 34 SPU76307_1 95.5% 32.2% VLESFLHDPL-VEWNRK------------KSSSKYPNNEANEVL--------DIIRKKFQGF----MPGETIPLSIEGQI 35 CEF35H12_2 87.7% 18.8% LAEIMSAGSKMQCFRAG-------------AETVRALEARFHVS--------STDEQLQQLVDT------LVEGSRDSYT 36 CEUC48B6_3 84.2% 6.9% EVQTLWLANRDDLLHWMKQ---------VTECLLI--------------------------------------------- 37 PIK1_YEAST 89.4% 17.3% MCEIMQKDNMQPCFDAG-------------EQTSVQLRQRFQLD--------LSEKEVDDFVEN-----FLIGKSLGSIY 38 HSPITR1_1 82.2% 17.4% LFSLMVDPNI-PDIALE------------PDKTVKKVQDKFRLD--------LSDEEAVHYMQS------LIDESVHALF consensus/100% .h.............................................................................. consensus/90% hht.h..s....th.......................t.......................h...............t.. consensus/80% hhthhh.ssh..pht..................h...ptth............sttph.p.h........h.tt..ts.h consensus/70% lhphhhtssh.sphptt..............tsh.hhpptht.t........hspppshphh........hhptt.tshh cov pid 401 . ] 419 1 ESR1_YEAST 100.0% 100.0% SKMYIGWLPF--------- 2 DM52192_1 85.6% 14.1% TQFNFFLHNLAQM------ 3 YAMB_SCHPO 97.9% 12.8% PLNQTLVDLVSQATNPQQL 4 HSU76308_1 96.9% 34.7% HYLIQEATDENLL------ 5 HS349941_1 95.5% 19.2% PAVITCDELLLGH------ 6 P3K1_SOYBN 82.2% 19.4% PQMVETIHRWAQ------- 7 VP34_SCHPO 82.5% 17.9% PQIIDRMHNLAQY------ 8 CEU56101_1 88.0% 16.6% TKTNWLFHAVKH------- 9 P11A_HUMAN 86.6% 17.6% TKMDWIFHTIKQ------- 10 P11B_HUMAN 87.0% 18.1% TKVNWMAHTVRK------- 11 YHP9_YEAST 96.6% 13.2% VTTQFILDCIGSAVSPRNL 12 FRAP_RAT 95.9% 25.7% GTTVPESIHSFIGD----- 13 PI4K_HUMAN 83.6% 15.2% SRTYDMIQYYQND------ 14 CEC47D12_5 97.6% 11.4% SRAKDSDNLARMPPTYHAW 15 P11G_HUMAN 86.3% 17.4% VQFNWFLHLVLG------- 16 DMPHOS3KI_ 87.0% 18.3% TSLNWASHNFSK------- 17 STT4_YEAST 83.6% 17.8% TKGYDEFQRLTNG------ 18 PI4K_DICDI 84.6% 18.5% TRYYDKYQSWLNG------ 19 HSC2PI3K_1 85.3% 15.4% TKLNFFIHNLAQMKFTGSD 20 CEUB0025_3 82.2% 17.0% NAKMAMISDIIHAYKQNLM 21 CEUB0261_2 95.5% 24.3% PEPLQVTEQLAMLTEQATS 22 TEL1_YEAST 98.3% 29.8% RALKGVEEKLMGN------ 23 P3K1_DICDI 86.0% 18.2% TQLNNFFHHLAH------- 24 P3K2_DICDI 86.0% 17.2% VLLNDIFHGWAH------- 25 2198789 82.9% 15.3% KLYDGFQYLTNGIM----- 26 P3K3_DICDI 86.0% 18.5% TTINFAIHIMAH------- 27 CEF39B1_1 85.6% 17.1% VRLNFVAHTVAQF------ 28 P3K4_DICDI 82.9% 19.0% PVIIEMAHKWLQY------ 29 YDBG_SCHPO 89.4% 16.7% TRLYDLFQNIT-------- 30 DM34925_2 94.2% 30.7% NFLINEATKVDNLASMYIG 31 TOR1_YEAST 95.2% 26.8% AEQQNETKNARA------- 32 MMU43678_1 99.0% 26.8% KVAERVLMRLQE------- 33 CET06E4_4 98.3% 24.7% MQVSQLASSLIE------- 34 SPU76307_1 95.5% 32.2% QELIKSAVNPKNLV----- 35 CEF35H12_2 87.7% 18.8% TRFYDSFQYYTNG------ 36 CEUC48B6_3 84.2% 6.9% ------------------- 37 PIK1_YEAST 89.4% 17.3% TRIYDQFQLIT-------- 38 HSPITR1_1 82.2% 17.4% AAVVEQIHKFAQY------ consensus/100% ................... consensus/90% ................... consensus/80% s.h...hp.h......... consensus/70% sth..hhpthtt.......