Family alignment for the RasGEFN domain, displayed in

                     cov    pid   1 [        .         .         .         .         :         .         .         . 80 
 1 MMCDC25H_1/1-1 100.0% 100.0%     CKVLQIRYASVERLLERLTDLRF--------LSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLEL-----    
 2 Ras/1-170      100.0%  63.5%     CKVPQIRYASVERLLERLTDLRF--------LSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLEL-XX--    
 3 S25716/1-146    90.5%  24.8%     AGIPIIKAGTVLKLIERLTYHMY--------ADPNFVRTFLTTYRSFCRPQELLSLLIERFEIPEPEPT----------E    
 4 158471/1-157    96.2%  27.0%     AGVPMIKGATLCKLIERLTYHIY--------ADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTG---TAG    
 5 SKCDC25A_1/1-1  82.9%  13.2%     DNKGNIKGGTKEALLEHLTSHQS--------IDLSFNLAMLLTFRSIFTTGEFLQALVERYNLYPP--------------    
 6 SCCDC25_1/1-13  82.9%  14.5%     DSRGKIRGGTKEALIEHLTSHEL--------VDAAFNVTMLITFRSILTTREFFYALIYRYNLYPP--------------    
 7 457494/1-134    84.2%  14.5%     GPIVRIKGGSKHALISYLTDNEK--------KDLFFNITFLITFRSIFTTTEFLSYLISQYNLDPP--------------    
 8 A56234/1-133    82.9%  15.0%     CKIRTIKAGTLEKLVENLLTAFG-------DNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTGP-------------    
 9 RRGNDSA_1/1-12  79.1%  15.6%     CKVRTVKAGTLEKLVEHLVPAFQ-------GSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPY-------------    
10 1354501/1-126   78.5%  14.4%     RSSRRLRAGTLEALVRHLLDARTA------GADMMFTPALLATHRAFTSTPALFGLVADRLEALESY-------------    
11 2911/1-114      71.5%  14.5%     KGHIVIK-ATPERLIMHLIEEHS-------IVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSL-------------    
12 CET14G10_9/1-1  71.5%  15.0%     CGQVLIK-GKPDKLIHHLVDERDH------NVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFADSIY-------------    
13 170835/1-132    82.9%  12.6%     DVKGNIKGGSKEALVSHLTHHLS--------LDSNFNAVFLLMFSSMMLLGELISLLIARFNIEPPE-------------    
14 1293099/1-124   77.8%  20.1%     QDDEVVKFASLNKLVEHLTHDSK--------HDLQFLKTFLMTYQSFCTPEKLMSKLQQRYNCPSGH-------------    
15 1125758/1-129   80.4%  16.2%     VKEKLIKAGTVERLVECLVGSDD-------MMDSRHFNVFFATYRSFTDSAIVLDCLLRRYETLENE-------------    
16 1665819/1-135   80.4%  12.0%     SDRYVVVSGTPEKILEHLLNDLHLEE-VQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQ-------------    
17 CET20G5_1/1-14  82.9%  10.8%     NCGYSVMAGKAEKILEYVLETRIDALGDDISELDVFVEDFILTHDAFMPDNTVCNFLKSYYFRTPYR-------------    
18 474982/1-143    88.6%  13.7%     DDGPDVRGGSGDILLVHATETDR-------KDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPF-------------    
19 AF053358_1/1-1  88.6%  11.2%     EDGPEVKGGYIDALIVHASRVQK-------VADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQ-------------    
20 SC12980_46/1-1  81.0%  11.7%     CVSKPVNSADLPALIVHLSSPLEG-------VDYNASADFFLIYRNFITPQDLHDLLIYRFRWCIRE-------------    
21 AF060819_1/1-1  75.3%  12.2%     SLGHLAKGASLDDLIDSCIQSFDADG--NLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEK-------------    
22 1326341/1-155   92.4%  13.2%     DNTGAVLSGSRDALIRRLVPTRD------FCPDESYIFSLLVNIRTFISPHELMQKIVQVRIFIPEEFHP----------    
23 5101/1-129      81.6%  12.0%     EQDGKIKTATLVFIINYLLRTDI--------DSTFFTTIFLNTYASMISSSDLFSILGAHFRFICSL-------------    
24 BEM2_YEAST      91.1%  13.1%     QRGHSTR-GLSDDNIGLLDYAFVKLTM----DNDIFTETFFNTYKSFTTTTTVLENMAKRYVGAKSCSVSISK-XX----    
25 BUD5_YEAST      73.4%  10.1%     QEVFRIQ-LYLNKMLPHNSHKWQK-------PSPFDSANLLLNFRDWTTDNALLQELLLSYPTINKN-------------    
26 F25B3.3         75.3%  10.4%     GTLDLDKGCTVEELLRGCIEAFDDSGKV---RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKD-------------    
   consensus/100%                   ........h.....l........................hh..h..hh.....h..h...h...................    
   consensus/90%                    t....hh.u...tll.hh..............s..h...hh..ap.hh.s..hht.h...a...................    
   consensus/80%                    pt...l+.ushptLltplhtt...........s..a.tshLhsacshhssttlhthLh.ha.h.................    
   consensus/70%                    sthh.l+suoh-tLlppLhpt...........s.tahtsFLhTaRsahsstplhphLhtpath.................    

                     cov    pid  81          .         1         .         .         .         .         :         . 160
 1 MMCDC25H_1/1-1 100.0% 100.0%     --XXKEVFRRMSLAN-----TGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQ--DFDTDDTLKYRVIC--FLEEV    
 2 Ras/1-170      100.0%  63.5%     SVSPASAFAIATAAAGHGSPPGFNNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQ--DFELNNELKMNVLN--LLEEV    
 3 S25716/1-146    90.5%  24.8%     ADRIAIENGDQPLS----------AELKRFRKEYIQP--VQLRVLNVCRHWVEHHFY--DFERDADLLQRMEE--FIGTV    
 4 158471/1-157    96.2%  27.0%     AGGMGGVGGDKEHKN-----SHR-EDWKRYRKEYVQP--VQFRVLNVLRHWVDHHFY--DFEKDPMLLEKLLN--FLEHV    
 5 SKCDC25A_1/1-1  82.9%  13.2%     ---EGVSYEEY----------------NIWVEKKQKP--VKIRVVNIMKTLFSQYWTP-SYYEP-GLDYMIG---FAQLA    
 6 SCCDC25_1/1-13  82.9%  14.5%     ---EGLSYDDY----------------NIWIEKKSNP--IKCRVVNIMRTFLTQYWTR-NYYEP-GIPLILN---FAKMV    
 7 457494/1-134    84.2%  14.5%     ---EDLCFEEY----------------NEWVTKKLIP--VKCRVVEIMTTFFKQYWFP-GYDEPDLATLNLDY--FAQVA    
 8 A56234/1-133    82.9%  15.0%     -----NCEDDG------------------SQSSPESKAVIRNAIASILRAWLDQCAE--DFREP-PHFPCLQK-LLEYLK    
 9 RRGNDSA_1/1-12  79.1%  15.6%     ------SSEDG-----------------------GPQDQLKNAISSILGTWLDQYSE--DFCQP-PDFPCLKQ-LVAYVQ    
10 1354501/1-126   78.5%  14.4%     --------------------------------PPGELERTTGVAISVLSTWLASHPE--DFGSEVKGQLDRLE--SFLLR    
11 2911/1-114      71.5%  14.5%     ----------------------------------------RDKVTRIVLLWVNNHFN--DFEGDPAMTRFLEE--FEKNL    
12 CET14G10_9/1-1  71.5%  15.0%     ----------------------------------------RDKVARLVLLWVNNHFN--DFETNDEMWNLLER--FEGAL    
13 170835/1-132    82.9%  12.6%     ----GLSYEEY----------------NLWVSKKRNP--IRLRVINIMKLLLEKNWSM-SYYNEP-VLRRWLT--FAHSD    
14 1293099/1-124   77.8%  20.1%     --------------------------------DEMATRNIQIRVINVLKGWVDNYYS--DFDDK--LIAMLRT--FIDQI    
15 1125758/1-129   80.4%  16.2%     ------------------------------VNGSTSALLVQNSIRQIVMCWLETYPE--DFYDSDKDFAMLSS--LLDFG    
16 1665819/1-135   80.4%  12.0%     -----------------------------GKEENSDVPRRKRKVLHLVSQWIALYKD--WLPEDEHSKMFLKT-IYRNVL    
17 CET20G5_1/1-14  82.9%  10.8%     ------------------------ATRDSITDSCTEEVRCKRRVVQFVYVWCSLLRV--NFFLNPVTNSFVEE-LFCHVI    
18 474982/1-143    88.6%  13.7%     ----ADTFKKRVSKN-----------TFFVLVRVVDELCLVELTEEILKLLMELVFR-LVCNGELSLARVLRK-NILDKV    
19 AF053358_1/1-1  88.6%  11.2%     ----VQDNKQKAAK-----------ETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQ-LVCSGQLYLAKLLRN-KFVEKV    
20 SC12980_46/1-1  81.0%  11.7%     ----------------------------ITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLPNITLRL-RLIEFL    
21 AF060819_1/1-1  75.3%  12.2%     -----------------------------------NSPGICLKICYFVRYWITEFWI--MFKMDASLTSTMEE--FQDLV    
22 1326341/1-155   92.4%  13.2%     -----LLDTDNLSHLSAQIYCMFAQNADSHNFAKEGRGRMFAHILRLCSEWATNIPY--DFKTEY-MRTRLNELLRLCAV    
23 5101/1-129      81.6%  12.0%     ------NFGK-------------------ISFISHEFYRVSKRFLDILLIWFESYLV--EELDNSKSIFFLFK--IYKVF    
24 BEM2_YEAST      91.1%  13.1%     ------------SLYDQNFPVWDMKVTDDENINLIYMAKIQIGAAEAILHLVKNHYS--DFTDDLCNNSTLLD--IIKIM    
25 BUD5_YEAST      73.4%  10.1%     -------------------------------------KHKNHSVPRLIQIWVESYWQ--DSETTLKDILNFW---YSHLA    
26 F25B3.3         75.3%  10.4%     -----------------------------------NSNSLQVKTCHLVRYWISAFPA--EFDLNPELAEQIKE--LKALL    
   consensus/100%                   ...........................................h..hh..hh..................h.........    
   consensus/90%                    ...........................................h.phh.hhht.h.....h.........h....h...h    
   consensus/80%                    .......................................hp.thhplhhhhhpph....sa.tp.....hl.p..hhthh    
   consensus/70%                    .......................................hp.plhpllphalppah...sa.ps..hh.hl.p..hhphh    

                     cov    pid 161          .         .  ] 183
 1 MMCDC25H_1/1-1 100.0% 100.0%     MHDP-DLLTQERKAAANIIRTLT    
 2 Ras/1-170      100.0%  63.5%     LRDP-DLLPQERKAAANILRALS    
 3 S25716/1-146    90.5%  24.8%     RGK---AMKKWVESITKIIQRKK    
 4 158471/1-157    96.2%  27.0%     NGK---SMRKWVDSVLKIVQRKN    
 5 SKCDC25A_1/1-1  82.9%  13.2%     KSQ---KISGADVLLSAIKGRLS    
 6 SCCDC25_1/1-13  82.9%  14.5%     VSE---KIPGAEDLLQKINEKLI    
 7 457494/1-134    84.2%  14.5%     IKE---NITGSVELLKEVNQKFK    
 8 A56234/1-133    82.9%  15.0%     QMM---PGSDPERRAQNLLEQFQ    
 9 RRGNDSA_1/1-12  79.1%  15.6%     LNM---PGSDLERRAHLLLAQLE    
10 1354501/1-126   78.5%  14.4%     TGYA--AREGVVGGSADLIRNLR    
11 2911/1-114      71.5%  14.5%     EDT----KMNGHLRLLNIACAAK    
12 CET14G10_9/1-1  71.5%  15.0%     ERD----GMHSQLSLLNIACSVK    
13 170835/1-132    82.9%  12.6%     QVQ----TYSLGNLLVNYLERLL    
14 1293099/1-124   77.8%  20.1%     QIKFPAPASAVNKSLTKMVEKLS    
15 1125758/1-129   80.4%  16.2%     GRNKLTELRAKARKQREVFKRIY    
16 1665819/1-135   80.4%  12.0%     DDVY--EYPILEKELKEFQKILG    
17 CET20G5_1/1-14  82.9%  10.8%     DDR---KRLGGMEDILTRIGSIR    
18 474982/1-143    88.6%  13.7%     DQK---KLLRCATSSQPLAARGV    
19 AF053358_1/1-1  88.6%  11.2%     TLYK---EPKVYGFVGELGGAGG    
20 SC12980_46/1-1  81.0%  11.7%     NDKHIEQYPKIISSCIINLKKN-    
21 AF060819_1/1-1  75.3%  12.2%     KAN----GEESHCHLIDTTQINS    
22 1326341/1-155   92.4%  13.2%     DKT----YQQKTTELQSTLRSSV    
23 5101/1-129      81.6%  12.0%     EVF----VVPHFASAEELLHSLS    
24 BEM2_YEAST      91.1%  13.1%     EQE---VSTEWPTRIANSKLQKS    
25 BUD5_YEAST      73.4%  10.1%     EYY---EYQELFADIVQLFINKK    
26 F25B3.3         75.3%  10.4%     DQE----GNRRHSSLIDIDSVPT    
   consensus/100%                   .......................    
   consensus/90%                    .......h.t.......h.t...    
   consensus/80%                    t......h.t..tth.phhtth.    
   consensus/70%                    ptp....h.th.pthhphhppht